{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T12:22:34Z","timestamp":1756902154896,"version":"3.44.0"},"reference-count":20,"publisher":"The Pediatric Pharmacy Association","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>Though standard household measuring devices (e.g., teaspoons, tablespoons) are often used in clinical practice to measure pediatric doses of polyethylene glycol 3350 (PEG-3350), no published \u00adliterature documents the accuracy of these measurements. Standard dosing for adults is 17 grams, which is 1 capful according to the manufacturer. The objective of this study was to determine the weight of household teaspoons and tablespoons of PEG-3350.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>PEG-3350 measurements were performed using 5 different household measuring teaspoons and tablespoons and the cap that accompanies the bottle for 3 different brands of PEG-3350. Using an electronic balance to determine weights, 3 investigators completed 5 measurements for each of the 5 measurement devices and PEG-3350 bottle caps as follows: leveled teaspoons and tablespoons, unleveled teaspoons and tablespoons, \u201cheaping\u201d tablespoons, half-capfuls, and capfuls.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>A leveled teaspoonful of PEG-3350 weighed \u223c3.3 grams and an unleveled teaspoonful weighed \u223c3.7 grams. A leveled, unleveled, and heaping tablespoon of PEG-3350 weighed about 10, 11, and 15 grams, respectively. Heaping tablespoons, half-capfuls, and capfuls resulted in the most measurement variability.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Use of a kitchen scale may be the most precise method of measurement, however not all patients have kitchen scales. Standard household measuring devices (teaspoons and tablespoons) may be used to conveniently measure PEG-3350 doses. Using 1 dedicated measurement device and leveling the dose may improve consistency, which could be beneficial for patients who are sensitive to dose variability.<\/jats:p>\n               <\/jats:sec>","DOI":"10.5863\/1551-6776-29.3.286","type":"journal-article","created":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T18:38:00Z","timestamp":1718044680000},"page":"286-291","source":"Crossref","is-referenced-by-count":0,"title":["Measurement of Polyethylene Glycol 3350 With Standard Household Measuring Devices"],"prefix":"10.5863","volume":"29","author":[{"given":"Kristen R.","family":"Nichols","sequence":"first","affiliation":[{"name":"Health Sciences Department (KN), Butler University College of Pharmacy and Health Sciences, Indianapolis, IN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darcie D.","family":"Streetman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolette A.","family":"Gordon","sequence":"additional","affiliation":[{"name":"PharmD Candidate, anticipated graduation May 2024, Butler University College of Pharmacy and Health Sciences (NG), Indianapolis, IN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chad A.","family":"Knoderer","sequence":"additional","affiliation":[{"name":"Pharmacy Practice Department (CA), Butler University College of Pharmacy and Health Sciences, Indianapolis, IN"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3883","published-online":{"date-parts":[[2024,6,10]]},"reference":[{"issue":"5","key":"2024061018373886800_i2331-348X-29-3-286-b01","first-page":"469","article-title":"Constipation in children and adolescents: evaluation and treatment","volume":"105","author":"Mulhem","year":"2022","journal-title":"Am Fam Physician"},{"key":"2024061018373886800_i2331-348X-29-3-286-b02","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jpeds.2018.02.029","article-title":"Prevalence of functional defecation disorders in children: a systematic review and meta-analysis","volume":"198","author":"Koppen","year":"2018","journal-title":"J Pediatr"},{"key":"2024061018373886800_i2331-348X-29-3-286-b03","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.jpeds.2017.12.012","article-title":"Prevalence of pediatric functional gastrointestinal disorders utilizing the Rome IV criteria","volume":"195","author":"Robin","year":"2018","journal-title":"J Pediatr"},{"issue":"8","key":"2024061018373886800_i2331-348X-29-3-286-b04","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1542\/pir.2018-0334","article-title":"Constipation","volume":"41","author":"LeLeiko","year":"2020","journal-title":"Pediatr Rev"},{"issue":"2","key":"2024061018373886800_i2331-348X-29-3-286-b05","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1097\/MPG.0000000000000266","article-title":"Evaluation and treatment of functional constipation in infants and children: evidence-based recommendations from ESPGHAN and NASPGHAN","volume":"58","author":"Tabbers","year":"2014","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"10","key":"2024061018373886800_i2331-348X-29-3-286-b06","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1093\/pch\/16.10.661","article-title":"Managing functional constipation in children","volume":"16","author":"Rowan-Legg","year":"2011","journal-title":"Paediatr Child Health"},{"issue":"2","key":"2024061018373886800_i2331-348X-29-3-286-b07","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.jpeds.2008.01.039","article-title":"PEG3350 in the treatment of childhood constipation: a multicenter, double-blinded, placebo-controlled trial","volume":"153","author":"Nurko","year":"2008","journal-title":"J Pediatr"},{"issue":"3","key":"2024061018373886800_i2331-348X-29-3-286-b08","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1067\/mpd.2001.117002","article-title":"Efficacy and optimal dose of daily polyethylene glycol 3350 for treatment of constipation and encopresis in children","volume":"139","author":"Pashankar","year":"2001","journal-title":"J Pediatr"},{"issue":"5","key":"2024061018373886800_i2331-348X-29-3-286-b09","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1002\/j.1536-4801.2004.tb00904.x","article-title":"Polyethylene glycol 3350 without electrolytes for the treatment of functional constipation in infants and toddlers","volume":"39","author":"Loening-Baucke","year":"2004","journal-title":"J Pediatr Gastroenterol Nutr"},{"year":"2022","author":"MiraLAX [package insert]","key":"2024061018373886800_i2331-348X-29-3-286-b10"},{"year":"1999","author":"MiraLAX [package insert]","key":"2024061018373886800_i2331-348X-29-3-286-b11"},{"key":"2024061018373886800_i2331-348X-29-3-286-b12","unstructured":"Pediatric Associates of Northern Colorado\n          . 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