{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T12:22:57Z","timestamp":1756902177486,"version":"3.44.0"},"reference-count":12,"publisher":"The Pediatric Pharmacy Association","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:p>Drug induced neutropenia is an uncommon but potentially serious side effect in children receiving prolonged \u03b2-lactam antibiotic therapy. Management of \u03b2-lactam induced neutropenia in children remains challenging and often requires antibiotic therapy interruption or modification. There are limited data in pediatric patients about use of granulocyte-colony stimulating factor (G-CSF) for the treatment of drug induced neutropenia. We report the use of G-CSF for \u03b2-lactam induced neutropenia in four pediatric patients between the ages of 3 months and 18 years with bacterial meningitis in this case series.<\/jats:p>","DOI":"10.5863\/jppt-24-00073","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T19:45:59Z","timestamp":1755114359000},"page":"504-507","source":"Crossref","is-referenced-by-count":0,"title":["Use of Granulocyte-Colony Stimulating Factor for Beta-Lactam Induced Neutropenia in Children With Bacterial Meningitis"],"prefix":"10.5863","volume":"30","author":[{"given":"Cheng Yu","family":"Yen","sequence":"first","affiliation":[{"name":"Department of Pharmacy (CYY, GTS), Texas Children\u2019s Hospital, Houston, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheldon L.","family":"Kaplan","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases, Department of Pediatrics (SLK, DLP, GTS), Baylor College of Medicine, Houston, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debra L.","family":"Palazzi","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases, Department of Pediatrics (SLK, DLP, GTS), Baylor College of Medicine, Houston, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grant","family":"Stimes","sequence":"additional","affiliation":[{"name":"Department of Pharmacy (CYY, GTS), Texas Children\u2019s Hospital, Houston, TX"},{"name":"Section of Infectious Diseases, Department of Pediatrics (SLK, DLP, GTS), Baylor College of Medicine, Houston, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3883","reference":[{"key":"i2331-348X-30-4-504-b01","series-title":"Front Pharmacol","first-page":"877","article-title":"Antibiotic-induced neutropenia in pediatric patients: new insights from pharmacoepidemiological analyses and a systematic Review","volume":"13","author":"Battini","year":"2022","unstructured":"Battini V, Mari A, Gringeri M, et al. Antibiotic-induced neutropenia in pediatric patients: new insights from pharmacoepidemiological analyses and a systematic Review. Front Pharmacol. 2022;13:877\u2013932."},{"issue":"2","key":"i2331-348X-30-4-504-b02","series-title":"J Pediatric Infect Dis Soc","first-page":"119","article-title":"Adverse events in pediatric patients receiving long-term outpatient antimicrobials","volume":"4","author":"Olson","year":"2015","unstructured":"Olson SC, Smith S, Weissman SJ, Kronman MP. Adverse events in pediatric patients receiving long-term outpatient antimicrobials. J Pediatric Infect Dis Soc. 2015;4(2):119\u2013125."},{"issue":"8","key":"i2331-348X-30-4-504-b03","series-title":"Ann Pharmacother","first-page":"1037","article-title":"A review of \u03b2-lactam-associated neutropenia and implications for cross-reactivity","volume":"55","author":"Cimino","year":"2021","unstructured":"Cimino C, Allos BM, Phillips EJ. 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Eur J Case Intern Med. 2024;11(7):004593."},{"year":"1994","series-title":"International Classification of Diseases","key":"i2331-348X-30-4-504-b08","unstructured":"International Classification of Diseases. 10th rev. World Health Organization; 1994."},{"issue":"5","key":"i2331-348X-30-4-504-b09","series-title":"Pediatr Infect Dis J","first-page":"541","article-title":"Complications of outpatient parenteral antibiotic therapy in childhood","volume":"20","author":"Gomez","year":"2001","unstructured":"Gomez M, Maraqa N, Alvarez A, Rathore M. Complications of outpatient parenteral antibiotic therapy in childhood. Pediatr Infect Dis J. 2001;20(5):541\u2013543."},{"key":"i2331-348X-30-4-504-b10","series-title":"Clin Pharmacol","first-page":"33","article-title":"Cefepime-induced neutropenia: a case report and literature review","volume":"15","author":"Koraysh","year":"2023","unstructured":"Koraysh S, Koleri J, Ali M. Cefepime-induced neutropenia: a case report and literature review. 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