{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T12:34:21Z","timestamp":1786365261934,"version":"build-2736575974"},"reference-count":11,"publisher":"The Pediatric Pharmacy Association","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec id=\"st1\">\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>Laparoscopic appendectomy is the primary treatment of appendicitis, but multimodal pain regimens are necessary to improve postoperative outcomes and optimize pain control. There are limited data comparing the analgesic requirements between perforated and non-perforated appendicitis and whether perforation requires more opioids due to its complications. The objective of this research is to compare the quantity of opioid administrations in perforated and non-perforated appendicitis following laparoscopic appendectomy to see if there is a difference in analgesic requirements.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"st2\">\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      This retrospective, cohort study included pediatric patients that underwent laparoscopic appendectomy for perforated and non-perforated appendicitis. Patients were evaluated from May 4, 2024 through December 31, 2024. The number of administrations of opioids, acetaminophen, and non-steroidal anti-inflammatory drugs were evaluated with binary \u03c7\n                      <jats:sup>2<\/jats:sup>\n                      test and Mann-Whitney\n                      <jats:italic>U<\/jats:italic>\n                      test.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"st3\">\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>A total of 60 patients were included, with 30 perforated appendicitis and 30 non-perforated appendicitis. Opioids were administered in 50% of perforated and 56.7% of non-perforated appendicitis patients (p = 0.79). A negative binomial regression showed perforated patients administered opioids received 1.58 times the number of opioid administrations on average (p = 0.19) and for each additional year of age, the expected number of opioid administrations increased by 11% (p = 0.05). The median number of non-opioid analgesic administrations were statistically significant in perforated appendicitis patients versus non-perforated, with 2.5 acetaminophen administrations versus 1 (p = 0.002) and 8 NSAID administrations versus 1 (p &lt; 0.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"st4\">\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>The number of opioids administered were similar across groups, but perforated appendicitis patients utilized more acetaminophen.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5863\/jppt-25-00076","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T12:26:18Z","timestamp":1786364778000},"page":"523-528","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of Opioid Administrations After Laparoscopic Appendectomy in Pediatrics With Perforated Versus Non-perforated Appendicitis: A Retrospective Cohort Study"],"prefix":"10.5863","volume":"31","author":[{"given":"Rachel","family":"Branton","sequence":"first","affiliation":[{"name":"Department of Pharmacy (RMB, EAF), Novant Health New Hanover Regional Medical Center, Wilmington, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Farrington","sequence":"additional","affiliation":[{"name":"Department of Pharmacy (RMB, EAF), Novant Health New Hanover Regional Medical Center, Wilmington, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3883","reference":[{"issue":"1","key":"JPPT-25-00076-b01","series-title":"J Clin Gastroenterol Treat","first-page":"042","article-title":"Acute appendicitis in pediatric patients: an updated narrative review","volume":"3","author":"Podany","year":"2017","unstructured":"Podany AB, Tsai AY, Dillon PW. Acute appendicitis in pediatric patients: an updated narrative review. J Clin Gastroenterol Treat. 2017;3(1):042."},{"issue":"11","key":"JPPT-25-00076-b02","series-title":"Cureus","first-page":"e49581","article-title":"Pain management throughout pediatric laparoscopic appendectomy: a systematic review","volume":"15","author":"Slouha","year":"2023","unstructured":"Slouha E, Krumbach B, Gregory JA, et al. Pain management throughout pediatric laparoscopic appendectomy: a systematic review. Cureus. 2023;15(11):e49581."},{"key":"JPPT-25-00076-b03","series-title":"The Reference Manual of Pediatric Dentistry","first-page":"456","article-title":"Pain management in infants, children, adolescents, and individuals with special health care needs","year":"2025","unstructured":"American Academy of Pediatric Dentistry. Pain management in infants, children, adolescents, and individuals with special health care needs. The Reference Manual of Pediatric Dentistry. Chicago, IL: American Academy of Pediatric Dentistry; 2025:456\u2013464"},{"issue":"5","key":"JPPT-25-00076-b04","series-title":"Surgery","first-page":"942","article-title":"Less postoperative opioids associated with decreased length of stay for children with perforated appendicitis","volume":"168","author":"Mahdi","year":"2020","unstructured":"Mahdi EM, Ourshalimian S, Russell CJ, et al. Less postoperative opioids associated with decreased length of stay for children with perforated appendicitis. Surgery. 2020; 168(5):942\u2013947."},{"issue":"9","key":"JPPT-25-00076-b05","series-title":"Pediatric Health Med Ther","first-page":"135","article-title":"Perforation risk in pediatric appendicitis: assessment and management","volume":"26","author":"Howell","year":"2018","unstructured":"Howell EC, Dubina ED, Lee SL. Perforation risk in pediatric appendicitis: assessment and management. Pediatric Health Med Ther. 2018;26(9):135\u2013145."},{"issue":"6","key":"JPPT-25-00076-b06","series-title":"J Pediatr Surg","first-page":"1043","article-title":"No pain is gain: A prospective evaluation of strict non-opioid pain control after pediatric appendectomy","volume":"55","author":"Gee","year":"2020","unstructured":"Gee KM, Jones ER, Nevarez N, et al. No pain is gain: A prospective evaluation of strict non-opioid pain control after pediatric appendectomy. J Pediatr Surg. 2020;55(6):1043\u20131047."},{"key":"JPPT-25-00076-b07","series-title":"Sampling fundamentals. Research Methodology","first-page":"91","author":"Das,","year":"2024","unstructured":"Das, S. Sampling fundamentals. Research Methodology. India: Kripa-Drishti Publications; 2024:91\u2013100."},{"issue":"1","key":"JPPT-25-00076-b08","series-title":"Health Psychol Behav Med","first-page":"436","article-title":"Too many zeros and\/or highly skewed? A tutorial on modelling health behaviour as count data with Poisson and negative binomial regression","volume":"9","author":"Green","year":"2021","unstructured":"Green JA. Too many zeros and\/or highly skewed? A tutorial on modelling health behaviour as count data with Poisson and negative binomial regression. Health Psychol Behav Med. 2021;9(1):436\u2013455."},{"key":"JPPT-25-00076-b09","series-title":"Negative Binomial Regression","author":"Hilbe","year":"2011","unstructured":"Hilbe JM. Negative Binomial Regression. 2nd ed. Cambridge University Press, New York; 2011."},{"issue":"1","key":"JPPT-25-00076-b10","series-title":"JAMA Surg","first-page":"76","article-title":"Guidelines for opioid prescribing in children and adolescents after surgery","volume":"156","author":"Kelley-Quon","year":"2021","unstructured":"Kelley-Quon LI, Kirkpatrick MG, Ricca RL, et al. Guidelines for opioid prescribing in children and adolescents after surgery. JAMA Surg. 2021;156(1):76\u201390."},{"issue":"1","key":"JPPT-25-00076-b11","series-title":"Pediatrics","first-page":"152","article-title":"Recognition and management of iatrogenically induced opioid dependence and withdrawal in children","volume":"133","author":"Galinkin","year":"2014","unstructured":"Galinkin J, Koh JL. Recognition and management of iatrogenically induced opioid dependence and withdrawal in children. Pediatrics. 2014;133(1):152\u2013155."}],"container-title":["The Journal of Pediatric Pharmacology and Therapeutics"],"original-title":[],"link":[{"URL":"https:\/\/jppt.kglmeridian.com\/view\/journals\/jppt\/31\/4\/article-p523.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/jppt.kglmeridian.com\/downloadpdf\/journals\/jppt\/31\/4\/article-p523.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jppt.kglmeridian.com\/downloadpdf\/journals\/jppt\/31\/4\/article-p523.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T12:26:18Z","timestamp":1786364778000},"score":1,"resource":{"primary":{"URL":"https:\/\/jppt.kglmeridian.com\/view\/journals\/jppt\/31\/4\/article-p523.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":11,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.5863\/jppt-25-00076","relation":{},"ISSN":["2331-348X","1551-6776"],"issn-type":[{"value":"2331-348X","type":"electronic"},{"value":"1551-6776","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]}}}