{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T15:14:55Z","timestamp":1781190895079,"version":"3.54.1"},"reference-count":110,"publisher":"The Pediatric Pharmacy Association","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec id=\"st1\">\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>Tranexamic acid (TXA) is a widely used antifibrinolytic agent in surgical and trauma settings in adults. This study aimed to evaluate the efficacy and safety of TXA in pediatric trauma patients across various clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"st2\">\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>A comprehensive literature search was conducted across 4 databases. We included clinical trials and observational studies that reported the use of TXA in pediatric trauma patients (aged \u226418 years). Data extraction and risk-of-bias assessment were performed by independent reviewers. Meta-analyses were conducted with RStudio software.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"st3\">\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>A total of 12 studies (2 randomized controlled trials [RCTs] and 10 observational) involving 66,398 pediatric trauma patients were included. Tranexamic acid was not significantly associated with reduction in hospital mortality (OR = 1.06; 95% CI, 0.32\u20133.45) but was associated with significantly shorter hospital stays (mean difference [MD] = \u22121.49; 95% CI, \u22122.43 to \u22120.56). The need for emergency mechanical ventilation was higher among the TXA group (OR = 4.29; 95% CI, 2.52\u20137.31), whereas the need for mechanical ventilation at discharge was lower (OR = 0.23; 95% CI, 0.08\u20130.64). Tranexamic acid use did not significantly alter the risk of thromboembolic events (OR = 0.72; 95% CI, 0.19\u20132.79) or poor neurological outcomes (OR = 2.51; 95% CI, 0.86\u20137.35).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"st4\">\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Tranexamic acid may reduce hospital length of stay in pediatric trauma patients, with inconsistent effects on mortality and adverse events. Its use should be individualized based on injury severity and resource availability. Further high-quality research is needed to confirm these findings and clarify the role of TXA in pediatric trauma care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5863\/jppt-25-00083","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T02:59:34Z","timestamp":1779937174000},"page":"347-365","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and Safety of Tranexamic Acid in Pediatric Trauma: A Systematic Review and Meta-Analysis"],"prefix":"10.5863","volume":"31","author":[{"given":"Mohammed","family":"Alsabri","sequence":"first","affiliation":[{"name":"Emergency Department (MA), Althawara Modern General Hospital, Sanaa, Yemen"},{"name":"Pediatric Emergency Department (MA), Department of Pediatrics, St. Christopher\u2019s Hospital, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yahya A.","family":"Mahmoud","sequence":"additional","affiliation":[{"name":"Faculty of Medicine (YAM), Al-Azhar University-Gaza, Gaza, Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amira A.","family":"Aboali","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology (AAA), Damanhour Teaching Hospital, General Organization for Teaching Hospitals and Institutes, Damanhour, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shree","family":"Rath","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences (SR), Bhubaneswar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa A.","family":"Khalifa","sequence":"additional","affiliation":[{"name":"Faculty of Medicine (MAK), Cairo University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamza A.","family":"Abdul-Hafez","sequence":"additional","affiliation":[{"name":"Department of Medicine (HAA), Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ammarah","family":"Tariq","sequence":"additional","affiliation":[{"name":"Rawalpindi Medical University (AT), Rawalpindi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3883","reference":[{"issue":"6","key":"JPPT-25-00083-b01","series-title":"J Trauma","first-page":"S68","article-title":"Traumatic injury and children: a national assessment","volume":"63","author":"Guice","year":"2007","unstructured":"Guice KS, Cassidy LD, Oldham KT. 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