{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T12:34:23Z","timestamp":1786365263742,"version":"build-2736575974"},"reference-count":32,"publisher":"The Pediatric Pharmacy Association","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:p>\n                    The aim of the study was to analyze the cellular and humoral mechanisms underlying the development of allergic laryngitis, to identify key diagnostic markers, and to evaluate the effectiveness of contemporary therapeutic approaches. The study examined the principal pathogenetic mechanisms of the disease, with particular emphasis on the Th2-mediated immune response, the role of cytokines\n                    <jats:italic>IL-4, IL-5,<\/jats:italic>\n                    and\n                    <jats:italic>IL-13<\/jats:italic>\n                    , immunoglobulin E (IgE), and mast cell degranulation, as well as current diagnostic methods, including laryngoscopy, skin testing, spirometry, and immunological assays. The findings confirm the leading role of Th2-dependent inflammation and IgE-mediated reactions in the development of laryngeal inflammation. The study concludes that allergen-specific immunotherapy combined with antihistamines and inhaled glucocorticosteroids is highly effective in improving symptom control and reducing the risk of relapse, supporting the integration of immunological markers and instrumental diagnostic methods to enhance diagnostic accuracy and enable personalized treatment strategies.\n                  <\/jats:p>","DOI":"10.5863\/jppt-25-00127","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:31:08Z","timestamp":1777941068000},"page":"471-482","source":"Crossref","is-referenced-by-count":0,"title":["Immunological Aspects Allergic Laryngitis: Role of Cellular and Humoral Mechanisms Directing Therapeutic Strategies"],"prefix":"10.5863","volume":"31","author":[{"given":"Maria Zofia","family":"Lisiecka","sequence":"first","affiliation":[{"name":"Department of Allergology, National Medical Institute of the Ministry of the Interior and Administration, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Luczak","sequence":"additional","affiliation":[{"name":"Clinic of Allergology and Lung Diseases, National Medical Institute of the Ministry of the Interior and Administration, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3883","reference":[{"key":"JPPT-25-00127-b01","year":"2025","unstructured":"World Allergy Organization (WAO). 2025. https:\/\/www.worldallergy.org\/ (access date: 12\/01\/2025)"},{"key":"JPPT-25-00127-b02","year":"2025","unstructured":"Allergic Rhinitis and Its Impact on Asthma (ARIA). 2025. https:\/\/www.euforea.eu\/aria (access date: 10\/08\/2025)"},{"issue":"2","key":"JPPT-25-00127-b03","series-title":"Otolaryngol Clin North Am","first-page":"419","article-title":"Laryngitis: types, causes, and treatments","volume":"41","author":"Dworkin","year":"2008","unstructured":"Dworkin JP. Laryngitis: types, causes, and treatments. Otolaryngol Clin North Am. 2008;41(2):419\u2013436."},{"issue":"5","key":"JPPT-25-00127-b04","series-title":"J Immunol Res","first-page":"371","article-title":"Immunological mechanisms in allergic diseases and allergen tolerance: The role of Treg cells","volume":"39","author":"Calzada","year":"2018","unstructured":"Calzada D, Baos S, Cremades-Jimeno L, C\u00e1rdaba B. Immunological mechanisms in allergic diseases and allergen tolerance: The role of Treg cells. J Immunol Res. 2018;39(5):371\u2013377."},{"key":"JPPT-25-00127-b05","series-title":"Front Immunol","first-page":"1349470","article-title":"Pathogenic role of different phenotypes of immune cells in airway allergic diseases: a study based on Mendelian randomization","volume":"15","author":"Xu","year":"2024","unstructured":"Xu Z, Li R, Wang L, et al. Pathogenic role of different phenotypes of immune cells in airway allergic diseases: a study based on Mendelian randomization. Front Immunol. 2024;15:1349470."},{"issue":"6","key":"JPPT-25-00127-b06","series-title":"J Exp Med","first-page":"e20221094","article-title":"T helper 2 cells in asthma","volume":"220","author":"Harker","year":"2023","unstructured":"Harker JA, Lloyd CM. T helper 2 cells in asthma. J Exp Med. 2023;220(6):e20221094."},{"key":"JPPT-25-00127-b07","series-title":"Understanding Allergic Airway Diseases: Contemporary Treatment Paradigm","first-page":"15","article-title":"Pathophysiology of allergic airways disease","author":"Gupta","year":"2024","unstructured":"Gupta G, Thapa R, Bhat AA, et al. Pathophysiology of allergic airways disease. In: Prasher P, Sharma M, Singh SK, et al, eds. Understanding Allergic Airway Diseases: Contemporary Treatment Paradigm. 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