{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T14:45:15Z","timestamp":1793371515305,"version":"4.5.0"},"reference-count":12,"publisher":"The Pediatric Pharmacy Association","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:p>This case report involves a 2-year-old female with no past medical history who presented after ingestion of an unknown amount of 300 mg bupropion extended-release tablets. Shortly after ingestion, the mother mechanically induced vomiting, which recovered only small pieces of the tablets. The patient remained asymptomatic for a short period, then she began vomiting and had several tonic-clonic seizures, leading to emergency medical service (EMS) being called and ultimately, intubation for airway protection. On arrival at the pediatric intensive care unit (estimated 6 hours post ingestion), the patient was unresponsive with fixed and dilated pupils and no cough, gag, or respiratory effort. An electrocardiogram revealed that the patient had a first-degree heart block with a prolonged QTc interval. The patient remained unresponsive while off sedation with no effort to breathe over the ventilator. A bolus of intravenous lipid emulsion (ILE) 1.5 mL\/kg followed by a continuous infusion of 0.5 mL\/kg\/min was administered (estimated 8 hours post ingestion). A few minutes following the start of the infusion, the patient began to spontaneously breathe over the ventilator. The patient was successfully extubated within 36 hours after ILE, and within 72 hours the patient had recovered to baseline and discharged home. This case displays successful use of ILE for bupropion toxicity in a young child. More studies are needed to fully understand the benefits and potential risks of the use of ILE in this population.<\/jats:p>","DOI":"10.5863\/jppt-25-00131","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T12:50:52Z","timestamp":1791809452000},"page":"671-674","source":"Crossref","is-referenced-by-count":1,"title":["Management of Bupropion Toxicity With Intravenous Lipid Emulsion Therapy in a Pediatric Patient: A Case Report"],"prefix":"10.5863","volume":"31","author":[{"given":"Morgan","family":"Bonincontri","sequence":"first","affiliation":[{"name":"Department of Pharmacy - Neonatology and Pediatrics (MB), Bethesda Hospital East, Boynton Beach, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley","family":"Snyder","sequence":"additional","affiliation":[{"name":"Department of Pharmacy - Pediatrics (BS), Medical University of South Carolina, Charleston, SC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Egea","sequence":"additional","affiliation":[{"name":"Pediatric Critical Care (ME), St. Mary\u2019s Medical Center, Pediatric Neurology (BF), St. Mary\u2019s Medical Center, West Palm Beach, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernardo","family":"Flasterstein","sequence":"additional","affiliation":[{"name":"Pediatric Critical Care (ME), St. Mary\u2019s Medical Center, Pediatric Neurology (BF), St. Mary\u2019s Medical Center, West Palm Beach, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittany","family":"Allison","sequence":"additional","affiliation":[{"name":"Department of Pharmacy - Emergency Medicine (BA), Tampa General Hospital, Tampa, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3883","reference":[{"issue":"1","key":"JPPT-25-00131-b01","series-title":"Reg Anesth Pain Med","first-page":"81","article-title":"American Society of Regional Anesthesia and Pain Medicine Local Anesthetic Systemic Toxicity checklist: 2020 version","volume":"46","author":"Neal","year":"2021","unstructured":"Neal JM, Neal EJ, Weinberg GL. American Society of Regional Anesthesia and Pain Medicine Local Anesthetic Systemic Toxicity checklist: 2020 version. Reg Anesth Pain Med. 2021;46(1):81\u201382."},{"issue":"3","key":"JPPT-25-00131-b02","series-title":"Eurasian J Med","first-page":"205","article-title":"Intravenous lipid emulsion therapy in drug overdose and poisoning: an updated review","volume":"56","author":"Bilvanisi","year":"2024","unstructured":"Bilvanisi S, G\u00fclen M, Sabak M, et al. Intravenous lipid emulsion therapy in drug overdose and poisoning: an updated review. Eurasian J Med. 2024;56(3):205\u2013212."},{"issue":"11","key":"JPPT-25-00131-b03","series-title":"Medicine (Baltimore)","first-page":"e37612","article-title":"Effect of lipid emulsion on neuropsychiatric drug-induced toxicity: a narrative review","volume":"103","author":"Hwang","year":"2024","unstructured":"Hwang Y, Sohn JT. Effect of lipid emulsion on neuropsychiatric drug-induced toxicity: a narrative review. Medicine (Baltimore). 2024;103(11):e37612."},{"issue":"16","key":"JPPT-25-00131-b04","series-title":"Circulation","first-page":"e149","article-title":"2023 American Heart Association focused update on the management of patients with cardiac arrest or life-threatening toxicity due to poisoning: an update to the American Heart Association guidelines for cardiopulmonary resuscitation and emergency cardiovascular care","volume":"148","author":"Lavonas","year":"2023","unstructured":"Lavonas EJ, Akpunonu PD, Arens AM, et al. 2023 American Heart Association focused update on the management of patients with cardiac arrest or life-threatening toxicity due to poisoning: an update to the American Heart Association guidelines for cardiopulmonary resuscitation and emergency cardiovascular care. Circulation. 2023;148(16):e149\u2013e184."},{"key":"JPPT-25-00131-b05","article-title":"PubChem compound summary for CID 444, bupropion","unstructured":"Bupropion. 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Neurocrit Care. 2021;34(3):1072\u20131089."},{"issue":"4","key":"JPPT-25-00131-b08","series-title":"J Pediatr Intensive Care","first-page":"242","article-title":"Successful management of adolescent bupropion overdose with intravenous lipid emulsion therapy","volume":"8","author":"Bornstein","year":"2019","unstructured":"Bornstein K, Montrief T, Anwar Parris M. Successful management of adolescent bupropion overdose with intravenous lipid emulsion therapy. J Pediatr Intensive Care. 2019;8(4):242\u2013246."},{"issue":"12","key":"JPPT-25-00131-b09","series-title":"Eur J Case Rep Intern Med","first-page":"004025","article-title":"Successful management of severe bupropion toxicity with lipid emulsion therapy: a complex case report and literature review","volume":"10","author":"Eid","year":"2023","unstructured":"Eid F, Takla A, Eid MM, et al. Successful management of severe bupropion toxicity with lipid emulsion therapy: a complex case report and literature review. 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