{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T13:45:20Z","timestamp":1791812720929,"version":"4.3.4"},"reference-count":24,"publisher":"The Pediatric Pharmacy Association","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10]]},"abstract":"\n OBJECTIVE<\/jats:title>\n Intravenous (IV) ibuprofen has recently been approved for treating moderate acute pain and fever, but evidence in pediatric use remains limited. This study aimed to evaluate the short-term safety of IV ibuprofen in children treated in a pediatric emergency department (PED).<\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n A prospective observational study was conducted including children aged 6 months to younger than 14 years who received IV ibuprofen between January 2021 and September 2023 in a PED of a tertiary hospital. IV ibuprofen was administered for moderate acute pain or fever when oral administration was not feasible due to vomiting or the need for fasting before a potential surgical intervention. Physicians documented patient history, previous analgesia, reasons for consultation and IV ibuprofen administration, vital signs, pain scores (0\u201310) before and 10 minutes after administration, and any adverse events (AEs).<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n We included 287 patients, with a median age of 9 years (IQR, 6\u201311). No serious AEs occurred, and no hospital admissions were required due to IV ibuprofen. Mild AEs occurred in 15 patients (5.2%), most commonly transient pain or itching at the infusion site. One patient developed a mild skin rash leading to treatment discontinuation, with complete recovery. Pain scores showed a median reduction of 3 points (IQR, 2\u20134).<\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS.<\/jats:title>\n Short-term use of IV ibuprofen in the PED was associated with an acceptable safety profile and clinically relevant pain reduction. However, further research is needed to confirm these findings and to evaluate safety with repeated dosing or longer duration of use.<\/jats:p>\n <\/jats:sec>","DOI":"10.5863\/jppt-25-00160","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T12:50:53Z","timestamp":1791809453000},"page":"653-658","source":"Crossref","is-referenced-by-count":0,"title":["Safety of Intravenous Ibuprofen Administration in the Pediatric Emergency Department"],"prefix":"10.5863","volume":"31","author":[{"given":"Silvia Cerezo","family":"Corredera","sequence":"first","affiliation":[{"name":"Pediatric Emergency Department (PED) - Hospital Universitario Cruces, Barakaldo, Basque Country, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikel Olabarri","family":"Garcia","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department (PED) - Hospital Universitario Cruces, Barakaldo, Basque Country, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina Lillo","family":"D\u00edaz","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department (PED) - Hospital Universitario Cruces, Barakaldo, Basque Country, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Benito","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department (PED) - Hospital Universitario Cruces, Barakaldo, Basque Country, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Mintegi","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department (PED) - Hospital Universitario Cruces, Barakaldo, Basque Country, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia Garcia","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department (PED) - Hospital Universitario Cruces, Barakaldo, Basque Country, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3883","reference":[{"issue":"6","key":"JPPT-25-00160-b01","series-title":"Pediatr Clin North Am","first-page":"1327","article-title":"Non-steroidal anti-inflammatory drugs in newborns and infants","volume":"64","author":"Aranda","year":"2017","unstructured":"Aranda JV, Salomone F, Valencia GB, et al. Non-steroidal anti-inflammatory drugs in newborns and infants. Pediatr Clin North Am. 2017;64(6):1327\u20131340."},{"issue":"6","key":"JPPT-25-00160-b02","series-title":"Paediatr Drugs","first-page":"603","article-title":"Efficacy and safety of NSAIDs in infants: a comprehensive review of the literature of the past 20 years","volume":"24","author":"Ziesenitz","year":"2022","unstructured":"Ziesenitz VC, Welzel T, van Dyk M, et al. Efficacy and safety of NSAIDs in infants: a comprehensive review of the literature of the past 20 years. Paediatr Drugs. 2022;24(6):603\u2013655."},{"key":"JPPT-25-00160-b03","series-title":"J Pain Res","first-page":"67","article-title":"Intravenous ibuprofen: the first injectable product for the treatment of pain and fever","volume":"3","author":"Bookstaver","year":"2010","unstructured":"Bookstaver PB, Miller AD, Rudisill CN, et al. Intravenous ibuprofen: the first injectable product for the treatment of pain and fever. J Pain Res. 2010;3:67\u201379."},{"key":"JPPT-25-00160-b04","article-title":"Clinical review of NDA 22-348 supplement 5: IV ibuprofen in pediatric patients ages 6 months and older. US Food and Drug Administration","author":"Fang","year":"2015","unstructured":"Fang C. Clinical review of NDA 22-348 supplement 5: IV ibuprofen in pediatric patients ages 6 months and older. US Food and Drug Administration. 2015. Accessed April 15, 2024. https:\/\/www.fda.gov\/media\/95405\/download"},{"key":"JPPT-25-00160-b05","article-title":"Ficha t\u00e9cnica de Ibuprofeno B. Braun pedi\u00e1trico 200 mg soluci\u00f3n para perfusi\u00f3n","unstructured":"Agencia Espa\u00f1ola de Medicamentos y Productos Sanitarios. Ficha t\u00e9cnica de Ibuprofeno B. Braun pedi\u00e1trico 200 mg soluci\u00f3n para perfusi\u00f3n. Updated April 2024. Accessed April 30, 2024. https:\/\/cima.aemps.es\/cima\/pdfs\/es\/ft\/85161\/85161_ft.pdf"},{"key":"JPPT-25-00160-b06","series-title":"Int J Pediatr Otorhinolaryngol","first-page":"109965","article-title":"Intraoperative intravenous ibuprofen use is not associated with increased post-tonsillectomy bleeding","volume":"133","author":"Patel","year":"2020","unstructured":"Patel NK, Shah SJ, Lee NK, et al. Intraoperative intravenous ibuprofen use is not associated with increased post-tonsillectomy bleeding. Int J Pediatr Otorhinolaryngol. 2020;133:109965."},{"issue":"5","key":"JPPT-25-00160-b07","series-title":"Paediatr Anaesth","first-page":"483","article-title":"A multicenter, randomized, double-blind placebo-controlled, single dose trial of the safety and efficacy of intravenous ibuprofen for treatment of pain in pediatric patients undergoing tonsillectomy","volume":"24","author":"Moss","year":"2014","unstructured":"Moss JR, Watcha MF, Bendel LP, et al. 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Front Pediatr. 2022;10:956660."},{"issue":"3","key":"JPPT-25-00160-b09","series-title":"J Cardiothorac Vasc Anesth","first-page":"445","article-title":"The analgesic effects of the addition of intravenous ibuprofen to a multimodal analgesia regimen for pain management after pediatric cardiac surgery: a randomized controlled study","volume":"37","author":"Abdelbaser","year":"2023","unstructured":"Abdelbaser I, Abo-Zeid M, Hayes S, et al. The analgesic effects of the addition of intravenous ibuprofen to a multimodal analgesia regimen for pain management after pediatric cardiac surgery: a randomized controlled study. J Cardiothorac Vasc Anesth. 2023;37(3):445\u2013450."},{"issue":"1","key":"JPPT-25-00160-b10","series-title":"BMC Pediatr","first-page":"42","article-title":"A multicenter, randomized, open-label, active-comparator trial to determine the efficacy, safety, and pharmacokinetics of intravenous ibuprofen for treatment of fever in hospitalized pediatric patients","volume":"17","author":"Khalil","year":"2017","unstructured":"Khalil SN, Hahn BJ, Chumpitazi CE, et al. A multicenter, randomized, open-label, active-comparator trial to determine the efficacy, safety, and pharmacokinetics of intravenous ibuprofen for treatment of fever in hospitalized pediatric patients. BMC Pediatr. 2017;17(1):42."},{"issue":"3","key":"JPPT-25-00160-b11","series-title":"Pediatr Nurs","first-page":"293","article-title":"The FLACC: a behavioral scale for scoring postoperative pain in young children","volume":"23","author":"Merkel","year":"1997","unstructured":"Merkel SI, Voepel-Lewis T, Shayevitz JR, Malviya S. 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Eur J Soc Psychol. 2021;51(3):485\u2013504."},{"issue":"2","key":"JPPT-25-00160-b14","series-title":"Pediatrics","first-page":"349","article-title":"Intravenous acetaminophen in the United States: iatrogenic dosing errors","volume":"129","author":"Dart","year":"2012","unstructured":"Dart RC, Rumack BH. Intravenous acetaminophen in the United States: iatrogenic dosing errors. Pediatrics. 2012;129(2):349\u2013353."},{"key":"JPPT-25-00160-b15","series-title":"J Pain Res","first-page":"753","article-title":"An integrated safety analysis of intravenous ibuprofen (Caldolor) in adults","volume":"8","author":"Southworth","year":"2015","unstructured":"Southworth SR, Woodward EJ, Peng A, et al. An integrated safety analysis of intravenous ibuprofen (Caldolor) in adults. J Pain Res. 2015;8:753\u2013765."},{"issue":"2","key":"JPPT-25-00160-b16","series-title":"Clin Ther","first-page":"360","article-title":"Intravenous Ibuprofen Surveillance Trial Investigational Sites. 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CJEM. 2016;18(1):19\u201327."}],"container-title":["The Journal of Pediatric Pharmacology and Therapeutics"],"original-title":[],"link":[{"URL":"https:\/\/jppt.kglmeridian.com\/view\/journals\/jppt\/31\/5\/article-p653.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/jppt.kglmeridian.com\/downloadpdf\/journals\/jppt\/31\/5\/article-p653.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jppt.kglmeridian.com\/downloadpdf\/journals\/jppt\/31\/5\/article-p653.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T12:50:53Z","timestamp":1791809453000},"score":1,"resource":{"primary":{"URL":"https:\/\/jppt.kglmeridian.com\/view\/journals\/jppt\/31\/5\/article-p653.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":24,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.5863\/jppt-25-00160","relation":{},"ISSN":["2331-348X","1551-6776"],"issn-type":[{"value":"2331-348X","type":"electronic"},{"value":"1551-6776","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]}}}