{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:50:56Z","timestamp":1777679456594,"version":"3.51.4"},"reference-count":24,"publisher":"The Pediatric Pharmacy Association","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,30]]},"abstract":"<jats:p>Iron deficiency is a common occurrence in the pediatric population, often leading to the development of anemia. The first line of treatment is oral iron administration for the resolution of anemia and replenishment of iron stores. Although rare, patients may present with allergic reactions to iron, which can limit treatment modalities. We present the case of a 14-month-old boy who presented with iron-deficiency anemia and demonstrated allergy to 2 oral iron formulations. Our institution developed a treatment plan that includes adding premedications and slowly titrating of the infusion rate for the administration of intravenous iron. The patient successfully tolerated 2 infusions without developing allergic reactions and experienced resolution of his iron-deficiency anemia. When patients with iron-deficiency anemia are allergic to oral iron formulations, their treatment options are limited. There are a few reports of effective desensitizations with intravenous ferric carboxymaltose in pediatric patients. Our successful experience may help guide other institutions with similar patients.<\/jats:p>","DOI":"10.5863\/jppt-26-00105","type":"journal-article","created":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T10:14:23Z","timestamp":1771928063000},"source":"Crossref","is-referenced-by-count":1,"title":["Administration of Intravenous Ferric Carboxymaltose in a Patient With Iron-Deficiency Anemia and Allergy to 2 Oral Iron Preparations"],"prefix":"10.5863","author":[{"given":"Jordan","family":"Wallace","sequence":"first","affiliation":[{"name":"Department of Pharmacy (JW), Golisano Children\u2019s Hospital of SWFL, Fort Myers, FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Trabal","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\/Oncology (AT), Joe DiMaggio Children\u2019s Hospital, Hollywood, FL"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3883","reference":[{"key":"JPPT-26-00105-b01","article-title":"Anemia in women and children","unstructured":"World Health Organization. Anemia in women and children. Accessed February 27, 2024. https:\/\/www.who.int\/data\/gho\/data\/themes\/topics\/anaemia_in_women_and_children"},{"issue":"2","key":"JPPT-26-00105-b02","series-title":"J Res Med Sci","first-page":"164","article-title":"Review on iron and its importance for human health","volume":"19","author":"Abbaspour","year":"2014","unstructured":"Abbaspour N, Hurrell R, Kelishadi R. Review on iron and its importance for human health. J Res Med Sci. 2014;19(2):164\u2013174."},{"issue":"9033","key":"JPPT-26-00105-b03","series-title":"Lancet","first-page":"992","article-title":"Randomised study of cognitive effects of iron supplementation in non-anaemic iron-deficient adolescent girls","volume":"348","author":"Bruner","year":"1996","unstructured":"Bruner AB, Joffe A, Duggan AK, et al. Randomised study of cognitive effects of iron supplementation in non-anaemic iron-deficient adolescent girls. Lancet. 1996;348(9033):992\u2013996."},{"key":"JPPT-26-00105-b04","series-title":"Drug Des Devel Ther","first-page":"51","article-title":"When is high-dose intravenous iron repletion needed? Assessing new treatment options","volume":"5","author":"Gozzard","year":"2011","unstructured":"Gozzard D. When is high-dose intravenous iron repletion needed? Assessing new treatment options. Drug Des Devel Ther. 2011;5:51\u201360."},{"issue":"4","key":"JPPT-26-00105-b05","series-title":"J Investig Allergol Clin Immunol","first-page":"305","article-title":"Anaphylaxis to oral iron salts. desensitization protocol for tolerance induction","volume":"18","author":"De Barrio","year":"2008","unstructured":"De Barrio M, Fuentes V, Tornero P, et al. Anaphylaxis to oral iron salts. desensitization protocol for tolerance induction. J Investig Allergol Clin Immunol. 2008;18(4):305\u2013308."},{"issue":"1","key":"JPPT-26-00105-b06","series-title":"AnnAllergy Asthma Innumol","first-page":"43","article-title":"Oral iron cutaneous adverse reaction and successful desensitization","volume":"84","author":"Ortega","year":"2000","unstructured":"Ortega N, Castillo R, Blanco C, et al. Oral iron cutaneous adverse reaction and successful desensitization. AnnAllergy Asthma Innumol. 2000;84(1):43\u201345."},{"issue":"2","key":"JPPT-26-00105-b07","series-title":"Curr Drug Saf","first-page":"145","article-title":"A safe and novel desensitization protocol with ferric carboxymaltose to treat iron deficiency anemia","volume":"11","author":"Montandon","year":"2016","unstructured":"Montandon S, Fajt M, Petrov A. A safe and novel desensitization protocol with ferric carboxymaltose to treat iron deficiency anemia. Curr Drug Saf. 2016;11(2):145\u2013148."},{"key":"JPPT-26-00105-b08","series-title":"Am J Ther","first-page":"1097","article-title":"Successful ferric carboxymaltose desensitization in a patient with prior reactions to intravenous iron therapies","volume":"10","author":"Elmes","year":"2023","unstructured":"Elmes J, Moore D, Pineda-Roman M. Successful ferric carboxymaltose desensitization in a patient with prior reactions to intravenous iron therapies. Am J Ther. 2023;10:1097."},{"issue":"5","key":"JPPT-26-00105-b09","series-title":"Int Arch Allergy Immunol","first-page":"449","article-title":"One-bag 8-step ferric carboxymaltose desensitization protocol for patients with a history of hypersensitivity reactions to iron preparations","volume":"185","author":"\u00d6zden","year":"2024","unstructured":"\u00d6zden \u015e, Tepetam FM, Atik \u00d6. One-bag 8-step ferric carboxymaltose desensitization protocol for patients with a history of hypersensitivity reactions to iron preparations. Int Arch Allergy Immunol. 2024;185(5):449\u2013455."},{"issue":"10","key":"JPPT-26-00105-b10","series-title":"Children (Basel)","first-page":"1473","article-title":"Hypersensitivity to intravenous iron preparations","volume":"9","author":"Caimmi","year":"2022","unstructured":"Caimmi S, Crisafulli G, Franceschini F, et al. Hypersensitivity to intravenous iron preparations. Children (Basel). 2022;9(10):1473."},{"issue":"2","key":"JPPT-26-00105-b11","series-title":"Gynecol Oncol","first-page":"393","article-title":"Rapid inpatient\/outpatient desensitization for chemotherapy hypersensitivity: standard protocol effective in 57 patients for 255 courses","volume":"99","author":"Lee","year":"2005","unstructured":"Lee CW, Matulonis UA, Castells MC. Rapid inpatient\/outpatient desensitization for chemotherapy hypersensitivity: standard protocol effective in 57 patients for 255 courses. Gynecol Oncol. 2005;99(2):393\u2013399."},{"issue":"7","key":"JPPT-26-00105-b12","series-title":"J Pediatr Pharmacol Ther","first-page":"671","article-title":"Medication desensitization: single intravenous bag method, in 3 pediatric patients","volume":"28","author":"Wallace","year":"2023","unstructured":"Wallace J, Garner L, Echols C, Phillips K, Kaplan JB. Medication desensitization: single intravenous bag method, in 3 pediatric patients. J Pediatr Pharmacol Ther. 2023;28(7):671\u2013673."},{"key":"JPPT-26-00105-b01","article-title":"Anemia in women and children","unstructured":"World Health Organization. Anemia in women and children. 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