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Double blind study of betahistine and placebo in the treatment of Meni\u00e8re's Syndrome [Studio a doppia cecita' tra cloridrato di betaistina e placebo nel trattamento delle sindromi Menieriformi]. Il Valsalva. 1984;60:302-12.","journal-title":"Valsalva","ISSN":"https:\/\/id.crossref.org\/issn\/0042-2371","issn-type":"print"},{"key":"ref14","first-page":"122","article-title":"Betahistine versus placebo in paroxysmal vertigo: a double-blind trial.","volume":"14","author":"Oosterveld","year":"1989","unstructured":"Oosterveld WJ, Blijleven W, Van Elferen LWM. Betahistine versus placebo in paroxysmal vertigo: a double-blind trial. J Drug Ther Res. 1989;14:122\u2013126.","journal-title":"J Drug Ther Res"},{"issue":"2","key":"ref15","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1001\/jama.1966.03100150133043","article-title":"Double-blind evaluation of a new treatment for M\u00e9ni\u00e8re's syndrome.","volume":"196","author":"Elia","year":"1966","unstructured":"Elia JC. 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Diagnostic and therapeutic strategy in Meni\u00e8re's disease. Guidelines of the French Otorhinolaryngology-Head and Neck Surgery Society (SFORL). Eur Ann Otorhinolaryngol Head Neck Dis. 2017 Jan 3. pii: S1879-7296(16)30222-8. | CrossRef | PubMed | CPG working group. Clinical Practice Guidelines Vertigo in Adults \u2013 2nd Edition. PhiliPPine Journal of otolaryngology-head and neck Surgery. 2014;29(1) | Link | Adrion C, Fischer CS, Wagner J, G\u00fcrkov R, Mansmann U, Strupp M; BEMED Study Group. Efficacy and safety of betahistine treatment in patients with Meniere's disease: primary results of a long term, multicentre, double blind, randomised, placebo controlled, dose defining trial (BEMED trial). 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