{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T13:56:39Z","timestamp":1747230999817,"version":"3.40.5"},"reference-count":31,"publisher":"Medwave Estudios Limitada","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medwave"],"abstract":"<jats:p>Introducci\u00f3n La psoriasis es una dermatosis inflamatoria cr\u00f3nica, con presentaci\u00f3n cl\u00ednica variable y cuya etiolog\u00eda involucra un componente gen\u00e9tico importante. Alrededor del mundo se han descrito m\u00faltiples variaciones gen\u00e9ticas asociadas a la enfermedad. Sin embargo, en poblaci\u00f3n colombiana se desconocen estas variantes. En este estudio se eval\u00faa el polimorfismo de nucle\u00f3tido \u00fanico rs10930046 (His460Arg) en el gen IFIH1 y su asociaci\u00f3n con el desarrollo de psoriasis en poblaci\u00f3n colombiana. Adem\u00e1s, se caracteriza a los individuos demogr\u00e1fica y cl\u00ednicamente.  M\u00e9todos Se realiz\u00f3 un estudio observacional de casos y controles, no pareado, que incluy\u00f3 51 individuos con psoriasis y 151 controles poblacionales, todos de ancestr\u00eda paisa (proveniente de la regi\u00f3n de Antioquia) auto reportada. A todos los individuos se les realiz\u00f3 genotipificaci\u00f3n del polimorfismo de nucle\u00f3tido \u00fanico rs10930046 (His460Arg) en el gen IFIH1 y se les determin\u00f3 la asociaci\u00f3n con la enfermedad. Se caracterizaron demogr\u00e1ficamente ambos grupos y los casos cl\u00ednicamente.  Resultados Se encontr\u00f3 que los casos presentaron una menor frecuencia del polimorfismo de nucle\u00f3tido \u00fanico rs10930046 (His460Arg) en el gen IFIH1 en relaci\u00f3n a los controles, 5 versus 22,67% respectivamente, con un an\u00e1lisis de asociaci\u00f3n al\u00e9lico. No hubo diferencias significativas en edad ni en sexo. La psoriasis vulgar fue la variante de presentaci\u00f3n m\u00e1s com\u00fan (78%). Alrededor de la mitad de los casos presentaron psoriasis ungular (56%), en menor frecuencia artritis psori\u00e1sica (19,6%) y el 45% de los casos tuvo alguna comorbilidad.  Conclusiones Los resultados obtenidos confirman que los portadores del polimorfismo de nucle\u00f3tido \u00fanico rs10930046 (His460Arg) en el gen IFIH1, presentan un riesgo disminuido de desarrollar psoriasis.<\/jats:p>","DOI":"10.5867\/medwave.2021.11.002099","type":"journal-article","created":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T18:01:35Z","timestamp":1640196095000},"page":"e002099-e002099","source":"Crossref","is-referenced-by-count":2,"title":["Protective association exhibited by a single nucleotide polymorphism of the IFIH1 gene in patients with psoriasis: A case-control study"],"prefix":"10.5867","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6116-3191","authenticated-orcid":false,"given":"Evelyn Vanesa","family":"Erazo Luna","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0373-2031","authenticated-orcid":false,"given":"Claudia Janeth","family":"Echavarr\u00eda Sierra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2667-7592","authenticated-orcid":false,"given":"Diana M.","family":"Cornejo-S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1555-2751","authenticated-orcid":false,"given":"Gloria","family":"Sanclemente","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1555-2751","authenticated-orcid":false,"given":"Nicol\u00e1s Guillermo","family":"Pineda Trujillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3888","published-online":{"date-parts":[[2021,12,22]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"Hern\u00e1ndez-V\u00e1squez A, Molinari L, Larrea N, Ciapponi A. 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