{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T13:57:01Z","timestamp":1747231021835,"version":"3.40.5"},"reference-count":0,"publisher":"Medwave Estudios Limitada","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medwave"],"abstract":"<jats:p>Background Two new SNPs have been recently associated to Alzheimer\u2019s disease in African American populations: FCGRIIB rs1050501 C\/T, and PILRA rs1859788 A\/G. The risk of Alzheimer\u2019s disease in FCGRIIB C and PILRA A allele carriers is three times higher than in non-carriers. However, the association between these and other single nucleotide polymorphisms (SNPs) has not been assessed.  Methods Linkage disequilibrium analysis, with r= 0.8 as a threshold value, was used to impute new candidate SNPs, on genomic data from both genes in 26 populations worldwide (n= 2504) from the 1000Genomes database.  Results Four SNPs (rs13376485, rs3767640, rs3767639 and rs3767641) were linked to rs1050501 and one (rs2405442) to rs1859788 in the whole sample.  Conclusions Five novel SNPs could be associated with Alzheimer\u2019s disease susceptibility and play a causal role, even if none of them are exon variants since their potential roles in the regulation of gene expression.<\/jats:p>","DOI":"10.5867\/medwave.2024.01.2754","type":"journal-article","created":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T18:40:06Z","timestamp":1708972806000},"page":"e2754-e2754","source":"Crossref","is-referenced-by-count":0,"title":["New candidate SNPs for genetic association with Alzheimer\u2019s disease: a linkage disequilibrium analysis for the FCGRIIB and PILRA genes"],"prefix":"10.5867","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5025-3095","authenticated-orcid":false,"given":"Alejandro","family":"Levi-Monsalve","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6911-4597","authenticated-orcid":false,"given":"Sergio Vladimir","family":"Flores","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3376-8804","authenticated-orcid":false,"given":"Germ\u00e1n","family":"Manriquez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8850-1018","authenticated-orcid":false,"given":"\u00c1ngel","family":"Roco-Videla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3888","published-online":{"date-parts":[[2024,2,26]]},"container-title":["Medwave"],"original-title":["Nuevos SNP candidatos para la asociaci\u00f3n gen\u00e9tica con la enfermedad de Alzheimer: un an\u00e1lisis de desequilibrio de ligamiento para los genes FCGRIIB y PILRA"],"deposited":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T18:40:08Z","timestamp":1708972808000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.medwave.cl\/revisiones\/analisis\/2754.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,26]]},"references-count":0,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2024,2,26]]}},"URL":"https:\/\/doi.org\/10.5867\/medwave.2024.01.2754","relation":{},"ISSN":["0717-6384"],"issn-type":[{"type":"electronic","value":"0717-6384"}],"subject":[],"published":{"date-parts":[[2024,2,26]]}}}