{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T20:10:46Z","timestamp":1786738246464,"version":"build-2736575974"},"reference-count":0,"publisher":"GN1 Sistemas e Publicacoes Ltd.","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ABO"],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:p>Purpose: To analyze the results of the 15-gene expression profile\/preferentially expressed antigen in\nmelanoma (15-GEPP) prognostic classifier and associated survival outcomes in a series of Brazilian patients\nwith posterior uveal melanoma. Methods: Patients born and raised in Brazil who were diagnosed with\nposterior uveal melanoma and underwent fine-needle aspiration biopsy for 15-GEPP prognostic testing\nusing the DecisionDx-Uveal melanoma and DecisionDx-PRAME assays between September 2020 and 2023\nwere included. All patients were diagnosed and treated by the senior author. Results: Of 236 patients\ndiagnosed with posterior uveal melanoma during the study period, 11 (4.6%) met the inclusion criteria,\nincluding six males and five females. Based on 15-GEPP results, seven patients (63.6%) were classified as\nClass 1 and 4 (36.4%) as Class 2. Preferentially expressed antigen in melanoma (PRAME) expression was\nnegative in six patients (54.6%) and positive in five patients (45.4%). During a mean follow-up of 36.4 \u00b1 17.6\nmonths, five patients developed metastasis: two with Class 2\/PRAME-positive tumors, one with Class 2\/\nPRAME-negative tumors, one with Class 1\/PRAME-positive tumors, and one with Class 1\/PRAME-negative\ntumors. Three of these patients died. The mean survival after the diagnosis of metastasis was 21.2 months\n(median: 17.0 months). Conclusions: The proportions of Class 1 versus Class 2 tumors and PRAME-negative\nversus PRAME-positive tumors as well as the prognostic performance of these biomarkers appear similar\nin Brazilian patients with posterior uveal melanoma compared with large published cohorts from North\nAmerica. Further studies with larger Brazilian cohorts are needed to validate these findings.<\/jats:p>","DOI":"10.5935\/0004-2749.2025-0356","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T19:15:15Z","timestamp":1786734915000},"page":"1-5","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic testing in Brazilian patients with uveal melanoma using 15-gene expression profile and preferentially expressed antigen in melanoma"],"prefix":"10.5935","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0111-7664","authenticated-orcid":false,"given":"Carolina C.","family":"Valente","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0400-8013","authenticated-orcid":false,"given":"Gustavo R.","family":"Gameiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8082-5626","authenticated-orcid":false,"given":"Beatriz K. T.","family":"Oguido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2652-0720","authenticated-orcid":false,"given":"Rodrigo","family":"Jorge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1104-9809","authenticated-orcid":false,"given":"J. William","family":"Harbour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2946-3757","authenticated-orcid":false,"given":"Zelia M.","family":"Correa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3948","published-online":{"date-parts":[[2026]]},"container-title":["Arquivos Brasileiros de Oftalmologia"],"original-title":[],"link":[{"URL":"https:\/\/www.scielo.br\/j\/abo\/a\/YXz3bsqGvg34TtTqx46Bsrq\/?lang=en&ilang=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T19:15:17Z","timestamp":1786734917000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.scielo.br\/j\/abo\/a\/YXz3bsqGvg34TtTqx46Bsrq\/?lang=en&ilang=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026]]},"published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.5935\/0004-2749.2025-0356","relation":{},"ISSN":["0004-2749"],"issn-type":[{"value":"0004-2749","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]}}}