{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:26:51Z","timestamp":1787772411292,"version":"build-2784847793"},"reference-count":0,"publisher":"GN1 Sistemas e Publicacoes Ltd.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JBRA"],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:p>Objective: To determine whether studies evaluating preimplantation genetic testing for aneuploidy (PGT-A) reach different conclusions depending on the denominator used to calculate live birth rates. Methods: A systematic review of studies published between 2017 and 2025 was conducted using PubMed, Scopus, and Google Scholar. Randomized and non-randomized studies comparing IVF\/ICSI cycles with and without PGT-A were included. Outcomes were analyzed per initiated cycle, oocyte retrieval, or embryo transfer. Relative risks were calculated using a random-effects model. Results: Eleven studies were included. No significant difference was observed when live birth rates were analyzed per initiated cycle or oocyte retrieval (RR 1.04, 95% CI 0.91\u20131.18). However, PGT-A significantly improved live birth rates when analyzed per embryo transfer (RR 1.21, 95% CI 1.05\u20131.40). Conclusion: The apparent benefit of PGT-A depends on the denominator used. Reporting outcomes per embryo transfer introduces selection bias and overestimates treatment effectiveness. Clinically meaningful outcomes should be reported per initiated cycle or oocyte retrieval.<\/jats:p>","DOI":"10.5935\/1518-0557.20260055","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:45:01Z","timestamp":1787769901000},"page":"591-593","source":"Crossref","is-referenced-by-count":0,"title":["Conflicting Conclusions in PGT-A: Live Birth Rates per Initiated Cycle or Oocyte Retrieval Show No Benefit, but Significant Improvement per Embryo Transfer"],"prefix":"10.5935","volume":"30","author":[{"given":"Isabela M","family":"Pasotti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Petersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura D","family":"Vagnini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana C","family":"Massaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna","family":"Petersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreia","family":"Nicoletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Ricci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila","family":"Zamara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata A","family":"Pouza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca C","family":"Matuella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisangela V.","family":"Espirito-Santo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joao B","family":"Meziara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio H","family":"Oliani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joao Batista","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose G","family":"Franco Jr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3948","published-online":{"date-parts":[[2026]]},"container-title":["JBRA Assisted Reproduction"],"original-title":[],"link":[{"URL":"https:\/\/www.jbra.com.br\/trab\/pub\/download_trabalho.php?fileSource=\/var\/www\/vhosts\/jbra.com.br\/media\/trab\/arq_8757&fileName=21%20-%203972%20-%20Conflicting%20Conclusions%20in%20PGT-A%20-%20Live%20Birth%20Rates%20per%20Initiated%20Cycle%20or%20Oocyte%20Retrieval%20Show%20.pdf&id_trabalho=3734","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:45:08Z","timestamp":1787769908000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jbra.com.br\/trab\/pub\/download_trabalho.php?fileSource=\/var\/www\/vhosts\/jbra.com.br\/media\/trab\/arq_8757&fileName=21%20-%203972%20-%20Conflicting%20Conclusions%20in%20PGT-A%20-%20Live%20Birth%20Rates%20per%20Initiated%20Cycle%20or%20Oocyte%20Retrieval%20Show%20.pdf&id_trabalho=3734"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026]]},"published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.5935\/1518-0557.20260055","relation":{},"ISSN":["1518-0557"],"issn-type":[{"value":"1518-0557","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]}}}