{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T11:29:24Z","timestamp":1792063764999,"version":"4.4.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,10,10]],"date-time":"2015-10-10T00:00:00Z","timestamp":1444435200000},"content-version":"vor","delay-in-days":1012,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brazilian Journal of Otorhinolaryngology"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.5935\/1808-8694.20130015","type":"journal-article","created":{"date-parts":[[2013,1,25]],"date-time":"2013-01-25T05:38:26Z","timestamp":1359092306000},"page":"89-94","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["Intravenous paracetamol and dipyrone for postoperative analgesia after day-case tonsillectomy in children: a prospective, randomized, double blind, placebo controlled study"],"prefix":"10.1016","volume":"79","author":[{"given":"Aysu Inan","family":"Kocum","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mesut","family":"Sener","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esra","family":"Caliskan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nesrin","family":"Bozdogan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deniz","family":"Micozkadioglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismail","family":"Yilmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anis","family":"Aribogan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.5935\/1808-8694.20130015_bib1","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1097\/01.aco.0000192789.78139.54","article-title":"Anesthesia for tonsillectomy","volume":"19","author":"J\u00f6hr","year":"2006","journal-title":"Curr Opin Anaesthesiol."},{"issue":"9","key":"10.5935\/1808-8694.20130015_bib2","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1097\/00003643-200009000-00006","article-title":"Double-blind randomized study of tramadol vs. paracetamol in analgesia afterday-case tonsillectomy in children","volume":"17","author":"Pendeville","year":"2000","journal-title":"Eur J Anaesthesiol."},{"key":"10.5935\/1808-8694.20130015_bib3","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1460-9592.1994.tb00121.x","article-title":"Post-operative pain in children after day case surgery","volume":"4","author":"Knight","year":"1994","journal-title":"Paediatr Anesth."},{"issue":"1","key":"10.5935\/1808-8694.20130015_bib4","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1093\/bja\/88.1.72","article-title":"Double-blind, placebo-controlled analgesic study of ibuprofen or rofecoxib in combination with paracetamol for tonsillectomy in children","volume":"88","author":"Pickering","year":"2002","journal-title":"Br J Anaesth."},{"issue":"5","key":"10.5935\/1808-8694.20130015_bib5","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s004820070021","article-title":"Management of postoperative pain in children","volume":"14","author":"Sittl","year":"2000","journal-title":"Schmerz."},{"issue":"4","key":"10.5935\/1808-8694.20130015_bib6","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1017\/S026502150700316X","article-title":"Topical ketamine and morphine for post-tonsillectomy pain","volume":"25","author":"Canbay","year":"2008","journal-title":"Eur J Anaesthesiol."},{"issue":"3","key":"10.5935\/1808-8694.20130015_bib7","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1017\/S0265021507002827","article-title":"Patient-controlled analgesia with lornoxicam vs. dipyrone for acute postoperative pain relief after septorhinoplasty: a prospective, randomized, double-blind, placebo-controlled study","volume":"25","author":"Sener","year":"2008","journal-title":"Eur J Anaesthesiol."},{"issue":"2","key":"10.5935\/1808-8694.20130015_bib8","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jclinane.2007.09.009","article-title":"Efficacy of lornoxicam for acute postoperative pain relief after septoplasty: a comparison with diclofenac, ketoprofen, and dipyrone","volume":"20","author":"Sener","year":"2008","journal-title":"J Clin Anesth."},{"issue":"5","key":"10.5935\/1808-8694.20130015_bib9","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/clpt.1984.78","article-title":"Drug discontinuations in the United Kingdom and the United States, 1964 to 1983: issues of safety","volume":"35","author":"Bakke","year":"1984","journal-title":"Clin Pharmacol Ther."},{"issue":"4","key":"10.5935\/1808-8694.20130015_bib10","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s00228-002-0465-2","article-title":"Agranulocytosis and other blood dyscra-sias associated with dipyrone (metamizole)","volume":"58","author":"Hedenmalm","year":"2002","journal-title":"Eur J Clin Pharmacol."},{"issue":"1","key":"10.5935\/1808-8694.20130015_bib11","doi-asserted-by":"crossref","first-page":"101","DOI":"10.2165\/00003495-200969010-00007","article-title":"Intravenous paracetamol (acetaminophen)","volume":"69","author":"Duggan","year":"2009","journal-title":"Drugs."},{"issue":"2","key":"10.5935\/1808-8694.20130015_bib12","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.anclin.2009.07.002","article-title":"Pharmacologic management of acute pediatric pain","volume":"27","author":"Kraemer","year":"2009","journal-title":"Anesthesiol Clin."},{"issue":"6","key":"10.5935\/1808-8694.20130015_bib13","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1046\/j.1460-9592.1997.d01-121.x","article-title":"The analgesic efficacy of an injectable prodrug of acetaminophen in children after orthopaedic surgery","volume":"7","author":"Granry","year":"1997","journal-title":"Paediatr Anesth."},{"issue":"4","key":"10.5935\/1808-8694.20130015_bib14","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.anclin.2010.08.006","article-title":"Intravenous acetaminophen","volume":"28","author":"Jahr","year":"2010","journal-title":"Anesthesiol Clin."},{"issue":"6","key":"10.5935\/1808-8694.20130015_bib15","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1093\/bja\/ael084","article-title":"Effects of intraoperative i.v. acetaminophen vs i.m. meperidine on post-tonsillectomy pain in children","volume":"96","author":"Alhashemi","year":"2006","journal-title":"Br J Anaesth."},{"issue":"8","key":"10.5935\/1808-8694.20130015_bib16","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1111\/j.1460-9592.2004.01518.x","article-title":"Tolerance and analgesic efficacy of a new i.v. paracetamol solution in children after inguinal hernia repair","volume":"15","author":"Murat","year":"2005","journal-title":"Paediatr Anaesth."},{"issue":"2","key":"10.5935\/1808-8694.20130015_bib17","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1093\/bja\/aem377","article-title":"Randomized controlled trial of duration of analgesia following intravenous or rectal acetaminophen after adenotonsillectomy in children","volume":"100","author":"Capici","year":"2008","journal-title":"Br J Anaesth."},{"issue":"1","key":"10.5935\/1808-8694.20130015_bib18","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jclinane.2010.07.001","article-title":"The efficacy of intravenous paracetamol versus tramadol for postoperative analgesia after adenotonsillectomy in children","volume":"23","author":"Uysal","year":"2011","journal-title":"J Clin Anesth."},{"key":"10.5935\/1808-8694.20130015_bib19","first-page":"395","article-title":"CHEOPS: A behavioral scale for rating postoperative pain in children","volume":"9","author":"McGrath","year":"1985"},{"issue":"6","key":"10.5935\/1808-8694.20130015_bib20","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1097\/MOO.0b013e32801042fa","article-title":"Painless tonsillectomy","volume":"14","author":"Kelly","year":"2006","journal-title":"Curr Opin Otolaryngol Head Neck Surg."},{"issue":"1-2","key":"10.5935\/1808-8694.20130015_bib21","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.pain.2005.05.012","article-title":"Systematic review on analgesics given for pain following tonsillectomy in children","volume":"117","author":"Hamunen","year":"2005","journal-title":"Pain."},{"issue":"3","key":"10.5935\/1808-8694.20130015_bib22","doi-asserted-by":"crossref","first-page":"105","DOI":"10.2147\/JPR.S4554","article-title":"Acute pain management in children","volume":"15","author":"Verghese","year":"2010","journal-title":"J Pain Res."},{"issue":"10","key":"10.5935\/1808-8694.20130015_bib23","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1185\/030079905X61857","article-title":"A comparison between IV paracetamol and IV metamizol for postoperative analgesia after retinal surgery","volume":"21","author":"Landwehr","year":"2005","journal-title":"Curr Med Res Opin."},{"issue":"2","key":"10.5935\/1808-8694.20130015_bib24","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1097\/EJA.0b013e32833fedfa","article-title":"Efficacy of intravenous paracetamol compared to dipyrone and parecoxib for postoperative pain management after minor-to-intermediate surgery: a randomised, double-blind trial","volume":"28","author":"Brodner","year":"2011","journal-title":"Eur J Anaesthesiol."},{"issue":"8","key":"10.5935\/1808-8694.20130015_bib25","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1097\/EJA.0b013e328329b0fd","article-title":"Paracetamol versus metamizol in the treatment of postoperative pain after breast surgery: a randomized, controlled trial","volume":"26","author":"Ohnesorge","year":"2009","journal-title":"Eur J Anaesthesiol."},{"issue":"10","key":"10.5935\/1808-8694.20130015_bib26","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1185\/030079906X132659","article-title":"Clinical equivalence of IV paracetamol compared to IV dipyrone for postoperative analgesia after surgery for breast cancer","volume":"22","author":"Kampe","year":"2006","journal-title":"Curr Med Res Opin."},{"issue":"1","key":"10.5935\/1808-8694.20130015_bib27","doi-asserted-by":"crossref","first-page":"25","DOI":"10.2165\/00124363-200202000-00009","article-title":"European Comission Enterprise Directorate-General. Better Medicines for children: proposed regulatory actions on pediatric medicinal products. Consultation Document","volume":"16","year":"2002","journal-title":"Int J Pharm Med."},{"key":"10.5935\/1808-8694.20130015_bib28","unstructured":"Regulation (EC) No. 1901\/2006 of the European Parliament and of the Council of 12 December 2006 on medicinal products for paediatric use and amending Regulation (EEC) No. 1768\/92, Directive 2001\/20\/EC, Directive 2001\/83\/EC and Regulation (EC) No 726\/2004 (Text with EEA relevance) Official Journal of the European Union L 378\/1 27.12.2006."},{"issue":"2","key":"10.5935\/1808-8694.20130015_bib29","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.anclin.2009.07.002","article-title":"Pharmacologic management of acute pediatric pain","volume":"27","author":"Kraemer","year":"2009","journal-title":"Anesthesiol Clin."},{"issue":"3","key":"10.5935\/1808-8694.20130015_bib30","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/j.1460-9592.1995.tb00275.x","article-title":"Postoperative morphine requirements, nausea and vomiting fallowing anaesthesia for tonsillectomy. Comparison of intravenous morphine and non-opioid analgesic techniques","volume":"5","author":"Mather","year":"1995","journal-title":"Paediatr Anaesth."},{"issue":"3","key":"10.5935\/1808-8694.20130015_bib31","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1034\/j.1399-6576.2000.440312.x","article-title":"Di-clofenac or acetaminophen for analgesia in paediatric tonsillectomy outpatients","volume":"44","author":"R\u00f8msing","year":"2000","journal-title":"Acta Anaesthesiol Scand."},{"issue":"6","key":"10.5935\/1808-8694.20130015_bib32","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1097\/00000542-200506000-00027","article-title":"Effects of nonsteroidal an-tiinflammatory drugs on patient-controlled analgesia morphine side effects: meta-analysis of randomized controlled trials","volume":"102","author":"Marret","year":"2005","journal-title":"Anesthesiology."},{"issue":"5","key":"10.5935\/1808-8694.20130015_bib33","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1213\/01.ANE.0000180204.64588.EC","article-title":"Postoperative nausea and vomiting is strongly influenced by postoperative opioid use in a dose related manner","volume":"101","author":"Roberts","year":"2005","journal-title":"Anesth Analg."}],"container-title":["Brazilian Journal of Otorhinolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1808869415304456?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1808869415304456?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T07:25:00Z","timestamp":1761722700000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1808869415304456"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["S1808869415304456"],"URL":"https:\/\/doi.org\/10.5935\/1808-8694.20130015","relation":{},"ISSN":["1808-8694"],"issn-type":[{"value":"1808-8694","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intravenous paracetamol and dipyrone for postoperative analgesia after day-case tonsillectomy in children: a prospective, randomized, double blind, placebo controlled study","name":"articletitle","label":"Article Title"},{"value":"Brazilian Journal of Otorhinolaryngology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.5935\/1808-8694.20130015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Associa\u00e7\u00e3o Brasileira de Otorrinolaringologia e Cirurgia C\u00e9rvico-Facial. Published by Elsevier Editora Ltda.","name":"copyright","label":"Copyright"}]}}