{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T15:38:42Z","timestamp":1772033922406,"version":"3.50.1"},"reference-count":90,"publisher":"Aging Biology LLC","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AgingBio"],"DOI":"10.59368\/agingbio.20240021","type":"journal-article","created":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T12:43:16Z","timestamp":1707828196000},"page":"20240021","source":"Crossref","is-referenced-by-count":3,"title":["Damage-Induced Senescent Immune Cells Regulate Regeneration of the Zebrafish Retina"],"prefix":"10.59368","volume":"1","author":[{"given":"James G.","family":"Patton","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Vanderbilt University","place":["Nashville, TN, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory J.","family":"Konar","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Vanderbilt University","place":["Nashville, TN, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zachary","family":"Flickinger","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Vanderbilt University","place":["Nashville, TN, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shivani","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Vanderbilt University","place":["Nashville, TN, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyle T.","family":"Vallone","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Vanderbilt University","place":["Nashville, TN, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Charles E.","family":"Lyon","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Vanderbilt University","place":["Nashville, TN, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Doshier","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Vanderbilt University","place":["Nashville, TN, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Audrey","family":"Lingan","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Vanderbilt University","place":["Nashville, TN, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Lyon","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Vanderbilt University","place":["Nashville, TN, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"38491","published-online":{"date-parts":[[2024,2,13]]},"reference":[{"key":"r1","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.gde.2016.05.009","article-title":"Retina regeneration in zebrafish","volume":"40","author":"Wan","year":"2016","unstructured":"(Figure 1). PMID: 27281280","journal-title":"Curr. Opin. Genet. Dev."},{"issue":"1","key":"r2","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1146\/annurev-vision-121219-081808","article-title":"Reprogramming Muller glia to regenerate retinal neurons","volume":"6","author":"Lahne","year":"2020","unstructured":"PMID: 32343929","journal-title":"Annu. Rev. Vis. Sci."},{"issue":"26","key":"r3","doi-asserted-by":"publisher","first-page":"7028","DOI":"10.1523\/JNEUROSCI.1624-07.2007","article-title":"Late-stage neuronal progenitors in the retina are radial M\u00fcller glia that function as retinal stem cells","volume":"27","author":"Bernardos","year":"2007","unstructured":"PMID: 17596452","journal-title":"J. Neurosci."},{"issue":"7","key":"r4","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1038\/nrn3723","article-title":"M\u00fcller glial cell reprogramming and retina regeneration","volume":"15","author":"Goldman","year":"2014","unstructured":"PMID: 24894585","journal-title":"Nat. Rev. Neurosci."},{"key":"r5","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.exer.2013.06.019","article-title":"A comparative analysis of M\u00fcller glia-mediated regeneration in the vertebrate retina","volume":"123","author":"Gallina","year":"2013","unstructured":"PMID: 23851023","journal-title":"Exp. Eye Res."},{"key":"r6","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.exer.2013.07.012","article-title":"Regulation of M\u00fcller glial dependent neuronal regeneration in the damaged adult zebrafish retina","volume":"123","author":"Gorsuch","year":"2013","unstructured":"PMID: 23880528","journal-title":"Exp. Eye Res."},{"key":"r7","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.632632","article-title":"miRNAs and Muller glia reprogramming during retina regeneration","volume":"8","author":"Konar","year":"2020","unstructured":"PMID: 33537319","journal-title":"Front Cell Dev. Biol."},{"key":"r8","doi-asserted-by":"publisher","DOI":"10.1126\/science.abb8598","article-title":"Gene regulatory networks controlling vertebrate retinal regeneration","volume":"370","author":"Hoang","year":"2020","unstructured":"PMID: 33004674","journal-title":"Science"},{"issue":"7665","key":"r9","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1038\/nature23283","article-title":"Stimulation of functional neuronal regeneration from Muller glia in adult mice","volume":"548","author":"Jorstad","year":"2017","unstructured":"PMID: 28746305","journal-title":"Nature"},{"issue":"11","key":"r10","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108507","article-title":"Microglia suppress Ascl1-induced retinal regeneration in mice","volume":"33","author":"Todd","year":"2020","unstructured":"PMID: 33326790","journal-title":"Cell Rep."},{"issue":"7719","key":"r11","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1038\/s41586-018-0425-3","article-title":"Restoration of vision after de novo genesis of rod photoreceptors in mammalian retinas","volume":"560","author":"Yao","year":"2018","unstructured":"PMID: 30111842","journal-title":"Nature"},{"issue":"7836","key":"r12","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1038\/s41586-020-2975-4","article-title":"Reprogramming to recover youthful epigenetic information and restore vision","volume":"588","author":"Lu","year":"2020","unstructured":"PMID: 33268865","journal-title":"Nature"},{"issue":"3","key":"r13","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109857","article-title":"Efficient stimulation of retinal regeneration from M\u00fcller glia in adult mice using combinations of proneural bHLH transcription factors","volume":"37","author":"Todd","year":"2021","unstructured":"PMID: 34686336","journal-title":"Cell Rep."},{"issue":"18","key":"r14","doi-asserted-by":"publisher","first-page":"E3719","DOI":"10.1073\/pnas.1617721114","article-title":"Immunomodulation-accelerated neuronal regeneration following selective rod photoreceptor cell ablation in the zebrafish retina","volume":"114","author":"White","year":"2017","unstructured":"PMID: 28416692","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"r15","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.892271","article-title":"Different inflammation responses modulate M\u00fcller glia proliferation in the acute or chronically damaged zebrafish retina","volume":"10","author":"Iribarne","year":"2022","unstructured":"PMID: 36120571","journal-title":"Front Cell Dev. Biol."},{"issue":"4","key":"r16","doi-asserted-by":"publisher","DOI":"10.3390\/cells10040783","article-title":"Inflammation regulates the multi-step process of retinal regeneration in zebrafish","volume":"10","author":"Nagashima","year":"2021","unstructured":"PMID: 33916186","journal-title":"Cells"},{"issue":"9","key":"r17","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.4103\/1673-5374.306059","article-title":"Inflammation induces zebrafish regeneration","volume":"16","author":"Iribarne","year":"2021","unstructured":"PMID: 33510057","journal-title":"Neural Regen. Res."},{"issue":"7","key":"r18","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1002\/glia.23792","article-title":"Inflammation and matrix metalloproteinase 9 (mmp-9) regulate photoreceptor regeneration in adult zebrafish","volume":"68","author":"Silva","year":"2020","unstructured":"PMID: 32034934","journal-title":"Glia"},{"key":"r19","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2017198118","article-title":"The immune response is a critical regulator of zebrafish pigment epithelial regeneration","volume":"118","author":"Leach","year":"2021","unstructured":"PMID: 34006636","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7","key":"r20","doi-asserted-by":"publisher","first-page":"4351","DOI":"10.1007\/s12035-022-02857-9","article-title":"Context-dependent effects of inflammation on retina regeneration","volume":"59","author":"Zhou","year":"2022","unstructured":"PMID: 35538305","journal-title":"Mol. Neurobiol."},{"issue":"1","key":"r21","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1186\/s12974-018-1185-6","article-title":"Dynamic changes in microglial and macrophage characteristics during degeneration and regeneration of the zebrafish retina","volume":"15","author":"Mitchell","year":"2018","unstructured":"PMID: 29804544","journal-title":"J. Neuroinflammation"},{"issue":"1","key":"r22","doi-asserted-by":"publisher","first-page":"4768","DOI":"10.1038\/s41598-019-41298-8","article-title":"Regeneration associated transcriptional signature of retinal microglia and macrophages","volume":"9","author":"Mitchell","year":"2019","unstructured":"PMID: 30886241","journal-title":"Sci. Rep."},{"issue":"1","key":"r23","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1186\/s12974-019-1505-5","article-title":"Reactive microglia and IL1beta\/IL-1R1-signaling mediate neuroprotection in excitotoxin-damaged mouse retina","volume":"16","author":"Todd","year":"2019","unstructured":"PMID: 31170999","journal-title":"J. Neuroinflammation"},{"issue":"5","key":"r24","doi-asserted-by":"publisher","first-page":"2910","DOI":"10.1007\/s12035-022-02783-w","article-title":"Disruption of miR-18a alters proliferation, photoreceptor replacement kinetics, inflammatory signaling, and microglia\/macrophage numbers during retinal regeneration in zebrafish","volume":"59","author":"Magner","year":"2022","unstructured":"PMID: 35246819","journal-title":"Mol. Neurobiol."},{"issue":"6","key":"r25","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1002\/glia.23601","article-title":"Retinal microglia signaling affects Muller cell behavior in the zebrafish following laser injury induction","volume":"67","author":"Conedera","year":"2019","unstructured":"PMID: 30794326","journal-title":"Glia"},{"issue":"3","key":"r26","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1016\/j.immuni.2019.02.007","article-title":"Microglial function is distinct in different anatomical locations during retinal homeostasis and degeneration","volume":"50","author":"O\u2019Koren","year":"2019","unstructured":"PMID: 30850344","journal-title":"Immunity"},{"issue":"8","key":"r27","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1038\/nn.4338","article-title":"A polarizing question: Do M1 and M2 microglia exist?","volume":"19","author":"Ransohoff","year":"2016","unstructured":"PMID: 27459405","journal-title":"Nat. Neurosci."},{"key":"r28","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.preteyeres.2014.11.004","article-title":"Retinal microglia: Just bystander or target for therapy?","volume":"45","author":"Karlstetter","year":"2015","unstructured":"PMID: 25476242","journal-title":"Prog. Retin. Eye Res."},{"key":"r29","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1007\/978-1-4614-3209-8_42","article-title":"Microglia-Muller cell interactions in the retina","volume":"801","author":"Wang","year":"2014","unstructured":"PMID: 24664715","journal-title":"Adv. Exp. Med. Biol."},{"issue":"3","key":"r30","doi-asserted-by":"publisher","first-page":"483","DOI":"10.11613\/bm.2019.030501","article-title":"Hallmarks of senescence and aging","volume":"29","author":"Dodig","year":"2019","unstructured":"PMID: 31379458","journal-title":"Biochem. Med. (Zagreb)"},{"issue":"1","key":"r31","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1146\/annurev-physiol-030212-183653","article-title":"Aging, cellular senescence, and cancer","volume":"75","author":"Campisi","year":"2013","unstructured":"PMID: 23140366","journal-title":"Annu. Rev. Physiol."},{"issue":"5","key":"r32","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/S0092-8674(00)81902-9","article-title":"Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a","volume":"88","author":"Serrano","year":"1997","unstructured":"PMID: 9054499","journal-title":"Cell"},{"issue":"3","key":"r33","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/S0092-8674(02)00734-1","article-title":"A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy","volume":"109","author":"Schmitt","year":"2002","unstructured":"PMID: 12015983","journal-title":"Cell"},{"issue":"1","key":"r34","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1083\/jcb.201708092","article-title":"Senescence and aging: Causes, consequences, and therapeutic avenues","volume":"217","author":"McHugh","year":"2018","unstructured":"PMID: 29114066","journal-title":"J. Cell. Biol."},{"issue":"2","key":"r35","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1007\/s10555-010-9220-9","article-title":"Senescent cells as a source of inflammatory factors for tumor progression","volume":"29","author":"Davalos","year":"2010","unstructured":"PMID: 20390322","journal-title":"Cancer Metastasis Rev."},{"issue":"9","key":"r36","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1016\/j.devcel.2022.04.005","article-title":"The role of senescence in cellular plasticity: Lessons from regeneration and development and implications for age-related diseases","volume":"57","author":"Ring","year":"2022","unstructured":"PMID: 35472291","journal-title":"Dev. Cell"},{"issue":"2","key":"r37","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1101\/gad.290635.116","article-title":"The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration","volume":"31","author":"Ritschka","year":"2017","unstructured":"PMID: 28143833","journal-title":"Genes Dev."},{"issue":"1","key":"r38","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109334","article-title":"Targeting senescent cells improves functional recovery after spinal cord injury","volume":"36","author":"Paramos-de-Carvalho","year":"2021","unstructured":"PMID: 34233184","journal-title":"Cell Rep."},{"issue":"1","key":"r39","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.cell.2017.02.031","article-title":"Targeted apoptosis of senescent cells restores tissue homeostasis in response to chemotoxicity and aging","volume":"169","author":"Baar","year":"2017","unstructured":"PMID: 28340339","journal-title":"Cell"},{"issue":"7372","key":"r40","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1038\/nature10600","article-title":"Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders","volume":"479","author":"Baker","year":"2011","unstructured":"PMID: 22048312","journal-title":"Nature"},{"issue":"594","key":"r41","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abb0203","article-title":"Cellular senescence inhibits renal regeneration after injury in mice, with senolytic treatment promoting repair","volume":"13","author":"Mylonas","year":"2021","unstructured":"PMID: 34011625","journal-title":"Sci. Transl. Med."},{"issue":"1","key":"r42","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13052","article-title":"Cell senescence contributes to tissue regeneration in zebrafish","volume":"19","author":"Da Silva-Alvarez","year":"2020","unstructured":"PMID: 31670873","journal-title":"Aging Cell"},{"key":"r43","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.72449","article-title":"The right time for senescence","volume":"10","author":"Paramos-de-Carvalho","year":"2021","unstructured":"PMID: 34756162","journal-title":"Elife"},{"issue":"6","key":"r44","doi-asserted-by":"publisher","first-page":"2809","DOI":"10.1007\/s11357-021-00457-4","article-title":"Targeting senescent retinal pigment epithelial cells facilitates retinal regeneration in mouse models of age-related macular degeneration","volume":"43","author":"Chae","year":"2021","unstructured":"PMID: 34601706","journal-title":"GeroScience"},{"issue":"11","key":"r45","doi-asserted-by":"publisher","first-page":"3173","DOI":"10.18632\/aging.101624","article-title":"Effects of senescent secretory phenotype acquisition on human retinal pigment epithelial stem cells","volume":"10","author":"Lazzarini","year":"2018","unstructured":"PMID: 30444724","journal-title":"Aging (Albany NY)"},{"key":"r46","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2021.108918","article-title":"Mechanisms of RPE senescence and potential role of alphaB crystallin peptide as a senolytic agent in experimental AMD","volume":"215","author":"Sreekumar","year":"2022","unstructured":"PMID: 34986369","journal-title":"Exp. Eye Res."},{"issue":"1","key":"r47","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1007939","article-title":"Regeneration of the zebrafish retinal pigment epithelium after widespread genetic ablation","volume":"15","author":"Hanovice","year":"2019","unstructured":"PMID: 30695061","journal-title":"PLoS Genet."},{"issue":"8","key":"r48","doi-asserted-by":"publisher","first-page":"2037","DOI":"10.1016\/j.celrep.2019.07.061","article-title":"The miR-216a-Dot1l regulatory axis is necessary and sufficient for Muller glia reprogramming during retina regeneration","volume":"28","author":"Kara","year":"2019","unstructured":"PMID: 31433981","journal-title":"Cell Rep."},{"issue":"2","key":"r49","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.ydbio.2014.05.005","article-title":"miR-203 regulates progenitor cell proliferation during adult zebrafish retina regeneration","volume":"392","author":"Rajaram","year":"2014","unstructured":"PMID: 24858486","journal-title":"Dev. Biol."},{"issue":"2","key":"r50","doi-asserted-by":"publisher","first-page":"367","DOI":"10.4103\/1673-5374.286972","article-title":"Inhibition of GABAA-rho receptors induces retina regeneration in zebrafish","volume":"16","author":"Kent","year":"2021","unstructured":"PMID: 32859800","journal-title":"Neural Regen. Res."},{"issue":"20","key":"r51","doi-asserted-by":"publisher","DOI":"10.1242\/dev.151837","article-title":"Cellular senescence in development, regeneration and disease","volume":"146","author":"Rhinn","year":"2019","unstructured":"PMID: 31575608","journal-title":"Development"},{"key":"r52","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.gde.2020.06.002","article-title":"Rising from the ashes: Cellular senescence in regeneration","volume":"64","author":"Walters","year":"2020","unstructured":"PMID: 32721584","journal-title":"Curr. Opin. Genet. Dev."},{"issue":"20","key":"r53","doi-asserted-by":"publisher","first-page":"9363","DOI":"10.1073\/pnas.92.20.9363","article-title":"A biomarker that identifies senescent human cells in culture and in aging skin in vivo","volume":"92","author":"Dimri","year":"1995","unstructured":"PMID: 7568133","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"r54","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1111\/j.1474-9726.2006.00199.x","article-title":"Senescence-associated beta-galactosidase is lysosomal beta-galactosidase","volume":"5","author":"Lee","year":"2006","unstructured":"PMID: 16626397","journal-title":"Aging Cell"},{"issue":"4","key":"r55","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1083\/jcb.201009094","article-title":"Four faces of cellular senescence","volume":"192","author":"Rodier","year":"2011","unstructured":"PMID: 21321098","journal-title":"J. Cell. Biol."},{"issue":"4","key":"r56","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1111\/acel.12592","article-title":"Quantitative identification of senescent cells in aging and disease","volume":"16","author":"Biran","year":"2017","unstructured":"PMID: 28455874","journal-title":"Aging Cell"},{"issue":"7\u20138","key":"r57","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1101\/gad.332643.119","article-title":"The senotherapeutic drug ABT-737 disrupts aberrant p21 expression to restore liver regeneration in adult mice","volume":"34","author":"Ritschka","year":"2020","unstructured":"PMID: 32139422","journal-title":"Genes Dev."},{"issue":"1","key":"r58","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s12974-021-02088-0","article-title":"Cellular senescence in the aging retina and developments of senotherapies for age-related macular degeneration","volume":"18","author":"Lee","year":"2021","unstructured":"PMID: 33482879","journal-title":"J. Neuroinflammation"},{"key":"r59","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.freeradbiomed.2019.02.005","article-title":"Sirt3 mediates the protective effect of hydrogen in inhibiting ROS-induced retinal senescence","volume":"135","author":"Li","year":"2019","unstructured":"PMID: 30735837","journal-title":"Free Radic. Biol. Med."},{"key":"r60","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.549","article-title":"Zebrafish galectin 3 binding protein is the target antigen of the microglial 4C4 monoclonal antibody","author":"Rovira","year":"2022","unstructured":"PMID: 36285351","journal-title":"Dev. Dyn."},{"key":"r61","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.892271","article-title":"Different inflammation responses modulate Muller glia proliferation in the acute or chronically damaged zebrafish retina","volume":"10","author":"Iribarne","year":"2022","unstructured":"PMID: 36120571","journal-title":"Front Cell. Dev. Biol."},{"issue":"10","key":"r62","doi-asserted-by":"publisher","first-page":"1608","DOI":"10.1002\/glia.22703","article-title":"Reactive microglia and macrophage facilitate the formation of Muller glia-derived retinal progenitors","volume":"62","author":"Fischer","year":"2014","unstructured":"PMID: 24916856","journal-title":"Glia"},{"issue":"6112","key":"r63","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1126\/science.1228773","article-title":"Acute inflammation initiates the regenerative response in the adult zebrafish brain","volume":"338","author":"Kyritsis","year":"2012","unstructured":"PMID: 23138980","journal-title":"Science"},{"issue":"10","key":"r64","doi-asserted-by":"publisher","first-page":"1608","DOI":"10.1002\/glia.22703","article-title":"Reactive microglia and macrophage facilitate the formation of M\u00fcller glia-derived retinal progenitors","volume":"62","author":"Fischer","year":"2014","unstructured":"PMID: 24916856","journal-title":"Glia"},{"issue":"21","key":"r65","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2017198118","article-title":"The immune response is a critical regulator of zebrafish retinal pigment epithelium regeneration","volume":"118","author":"Leach","year":"2021","unstructured":"PMID: 34006636","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"12","key":"r66","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201810234","article-title":"Targeting senescent cells in translational medicine","volume":"11","author":"Paez-Ribes","year":"2019","unstructured":"PMID: 31746100","journal-title":"EMBO Mol. Med."},{"issue":"10","key":"r67","doi-asserted-by":"publisher","first-page":"2504","DOI":"10.1002\/1878-0261.12761","article-title":"Clearance of therapy-induced senescent tumor cells by the senolytic ABT-263 via interference with BCL-XL \u2013BAX interaction","volume":"14","author":"Saleh","year":"2020","unstructured":"PMID: 32652830","journal-title":"Mol. Oncol."},{"issue":"4","key":"r68","doi-asserted-by":"publisher","first-page":"872","DOI":"10.3390\/ijms18040872","article-title":"Antioxidant and anti-senescence effect of Metformin on mouse olfactory ensheathing cells (mOECs) may be associated with increased brain-derived neurotrophic factor levels\u2014An ex vivo study","volume":"18","author":"\u015amieszek","year":"2017","unstructured":"PMID: 28425952","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"r69","doi-asserted-by":"publisher","DOI":"10.1038\/s41536-021-00172-w","article-title":"Metformin accelerates zebrafish heart regeneration by inducing autophagy","volume":"6","author":"Xie","year":"2021","unstructured":"PMID: 34625572","journal-title":"NPJ Regen. Med."},{"issue":"3","key":"r70","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1111\/acel.12075","article-title":"Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK\/NF-kappaB activation","volume":"12","author":"Moiseeva","year":"2013","unstructured":"PMID: 23521863","journal-title":"Aging Cell"},{"issue":"5","key":"r71","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.1167\/iovs.18-26422","article-title":"The common antidiabetic drug Metformin reduces odds of developing age-related macular degeneration","volume":"60","author":"Brown","year":"2019","unstructured":"PMID: 30973575","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"15","key":"r72","doi-asserted-by":"publisher","first-page":"6524","DOI":"10.1523\/JNEUROSCI.3838-12.2013","article-title":"Tumor necrosis factor-alpha is produced by dying retinal neurons and is required for Muller glia proliferation during zebrafish retinal regeneration","volume":"33","author":"Nelson","year":"2013","unstructured":"PMID: 23575850","journal-title":"J. Neurosci."},{"issue":"11","key":"r73","doi-asserted-by":"publisher","first-page":"4468","DOI":"10.7150\/ijbs.74954","article-title":"Metformin induces cell cycle arrest, apoptosis and autophagy through ROS\/JNK signaling pathway in human osteosarcoma: Erratum","volume":"18","author":"Li","year":"2022","unstructured":"PMID: 35864963","journal-title":"Int. J. Biol. Sci."},{"key":"r74","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.ymeth.2014.11.021","article-title":"LC3- and p62-based biochemical methods for the analysis of autophagy progression in mammalian cells","volume":"75","author":"Jiang","year":"2015","unstructured":"PMID: 25484342","journal-title":"Methods"},{"issue":"1","key":"r75","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1146\/annurev-pathol-121808-102144","article-title":"The senescence-associated secretory phenotype: The dark side of tumor suppression","volume":"5","author":"Copp\u00e9","year":"2010","unstructured":"PMID: 20078217","journal-title":"Ann. Rev. Pathol."},{"issue":"2","key":"r76","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1038\/nrc2560","article-title":"Senescence-messaging secretome: SMS-ing cellular stress","volume":"9","author":"Kuilman","year":"2009","unstructured":"PMID: 19132009","journal-title":"Nat. Rev. Cancer"},{"issue":"2","key":"r77","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1002\/dvdy.10220","article-title":"Tales of regeneration in zebrafish","volume":"226","author":"Poss","year":"2003","unstructured":"PMID: 12557199","journal-title":"Dev. Dyn."},{"issue":"1","key":"r78","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1002\/glia.23707","article-title":"Inflammation-induced mammalian target of rapamycin signaling is essential for retina regeneration","volume":"68","author":"Zhang","year":"2020","unstructured":"PMID: 31444939","journal-title":"Glia"},{"issue":"1","key":"r79","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000599","article-title":"A proteomic atlas of senescence-associated secretomes for aging biomarker development","volume":"18","author":"Basisty","year":"2020","unstructured":"PMID: 31945054","journal-title":"PLoS Biol."},{"issue":"2","key":"r80","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1172\/JCI1368","article-title":"IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses","volume":"101","author":"Xing","year":"1998","unstructured":"PMID: 9435302","journal-title":"J. Clin. Invest."},{"issue":"2","key":"r81","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.cytogfr.2011.02.003","article-title":"IL-6 signaling in autoimmunity, chronic inflammation and inflammation-associated cancer","volume":"22","author":"Neurath","year":"2011","unstructured":"PMID: 21377916","journal-title":"Cytokine Growth Factor Rev."},{"issue":"3","key":"r82","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1093\/intimm\/dxaa078","article-title":"IL-6 in inflammation, autoimmunity and cancer","volume":"33","author":"Hirano","year":"2021","unstructured":"PMID: 33337480","journal-title":"Int. Immunol."},{"issue":"11","key":"r83","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1093\/ijnp\/pyaa055","article-title":"Pro- and anti-inflammatory properties of interleukin (IL6) in vitro: Relevance for major depression and for human hippocampal neurogenesis","volume":"23","author":"Borsini","year":"2020","unstructured":"PMID: 32726406","journal-title":"Int. J. Neuropsychopharmacol."},{"issue":"2","key":"r84","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12711","article-title":"Senescence promotes in vivo reprogramming through p16(INK)(4a) and IL-6","volume":"17","author":"Mosteiro","year":"2018","unstructured":"PMID: 29280266","journal-title":"Aging Cell"},{"issue":"6","key":"r85","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1002\/jnr.23205","article-title":"Granulocyte macrophage colony-stimulating factor promotes regeneration of retinal ganglion cells in vitro through a mammalian target of rapamycin-dependent mechanism","volume":"91","author":"Legacy","year":"2013","unstructured":"PMID: 23456828","journal-title":"J. Neurosci. Res."},{"issue":"4","key":"r86","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1111\/acel.12344","article-title":"The Achilles\u2019 heel of senescent cells: From transcriptome to senolytic drugs","volume":"14","author":"Zhu","year":"2015","unstructured":"PMID: 25754370","journal-title":"Aging Cell"},{"key":"r87","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2021.111587","article-title":"Recent advances in the discovery of senolytics","volume":"200","author":"Zhang","year":"2021","unstructured":"PMID: 34656616","journal-title":"Mech. Ageing Dev."},{"issue":"5","key":"r88","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1111\/joim.13141","article-title":"Senolytic drugs: From discovery to translation","volume":"288","author":"Kirkland","year":"2020","unstructured":"PMID: 32686219","journal-title":"J. Intern. Med."},{"issue":"1","key":"r89","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-25453-2","article-title":"Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice","volume":"12","author":"Novais","year":"2021","unstructured":"PMID: 34480023","journal-title":"Nat. Commun."},{"issue":"2","key":"r90","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202101483","article-title":"Local delivery of senolytic drug inhibits intervertebral disc degeneration and restores intervertebral disc structure","volume":"11","author":"Lim","year":"2022","unstructured":"PMID: 34699690","journal-title":"Adv. Healthcare Mater."}],"container-title":["Aging Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/agingcelljournal.org\/Archive\/Volume3\/20240021\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T12:43:19Z","timestamp":1707828199000},"score":1,"resource":{"primary":{"URL":"https:\/\/agingcelljournal.org\/Archive\/Volume3\/20240021\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,13]]},"references-count":90,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,2,13]]}},"URL":"https:\/\/doi.org\/10.59368\/agingbio.20240021","relation":{},"subject":[],"published":{"date-parts":[[2024,2,13]]}}}