{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T17:07:04Z","timestamp":1775668024461,"version":"3.50.1"},"reference-count":11,"publisher":"Centre for Evaluation in Education and Science (CEON\/CEES)","issue":"2","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/BY\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Biochemistry"],"published-print":{"date-parts":[[2021]]},"abstract":"<jats:p>Background: Red blood cell distribution width (RDW) is frequently increased in inflammatory disorders, and the magnitude of its elevation correlates with disease severity. This study was hence aimed to explore RDW values in patients with psoriasis. Methods: The study population consisted of 366 adult patients with mild to severe plaque psoriasis and 366 age and sex-matched blood donor controls. For each psoriatic patient, demographic, clinical, and laboratory data were regularly collected. Results: RDW and MCV were significantly higher in psoriatic patients compared to controls (13.95 vs. 13.40% and 90.4 vs. 89 fL; both p &lt; 0.01). In order to assess whether RDW elevations were related to psoriasis severity, we divided our psoriatic patient population into two groups based on a PASI cut-off of 10. No significant differences were observed between the two groups (i.e., PASI &gt; 10 and 10) in terms of RDW (p = 0.36). Adopting different PASI cut-offs (i.e. 3, 5, 7, 12) did not result in statistically significant differences (p = 0.93, 0.48, 0.22, 0.42, respectively). In linear regression analysis, no significant correlation was found between RDW and PASI or CRP, nor with age, gender, or the psoriasis comorbidities listed in Table I. Furthermore, no significant difference in RDW values was noted between psoriatic patients with and without PsA (p = 0.27). Conclusions: The results of this study confirm that RDW is elevated in psoriatic patients, though the magnitude of its in - crease did not appear to be associated with disease severity.<\/jats:p>","DOI":"10.5937\/jomb0-27237","type":"journal-article","created":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T11:06:32Z","timestamp":1603191992000},"page":"199-201","source":"Crossref","is-referenced-by-count":9,"title":["Increased red blood cell distribution width in patients with plaque psoriasis"],"prefix":"10.5937","volume":"40","author":[{"given":"Paolo","family":"Gisondi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Geat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Lippi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Montagnana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giampiero","family":"Girolomoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3964","reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Salvagno GL, Sanchis-Gomar F, Picanza A, Lippi G. Red blood cell distribution width: a simple parameter with multiple clinical applications. Crit Rev Clin Lab Sci 2015; 52: 86-105;","DOI":"10.3109\/10408363.2014.992064"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Fava C, Cattazzo F, Hu Z, Lippi G, Montagnana M. The role of red blood cell distribution width (RDW) in cardiovascular risk assessment: useful or hype? Ann Transl Med 2019; 7: 581;","DOI":"10.21037\/atm.2019.09.58"},{"key":"ref3","unstructured":"Do\u011fan S, Atakan N. Red blood cell distribution width is a reliable marker of inflammation in plaque psoriasis. Acta Dermatovenerol Croat 2017; 25: 26-31;"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Conic RR, Damiani G, Schrom KP, RamserAE, Zheng C, Xu R, et al. Psoriasis and psoriatic arthritis cardiovascular disease endotypes identified by red blood cell distribution width and mean platelet volume. J Clin Med 2020; 9: 186;","DOI":"10.3390\/jcm9010186"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Kim DS, Shin D, Jee H, Kim T, Kim SH, Kim DY, et al. Red blood cell distribution width is increased in patients with psoriasis vulgaris: A retrospective study on 261 patients. J Dermatol 2015; 42: 567-71;","DOI":"10.1111\/1346-8138.12865"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Finlay AY. Current severe psoriasis and the rule of tens. Br J Dermatol 2005; 152: 861-7;","DOI":"10.1111\/j.1365-2133.2005.06502.x"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Schmitt J, Wozel G. The psoriasis area and severity index is the adequate criterion to define severity in chronic plaque-type psoriasis. Dermatology 2005; 210: 194-9;","DOI":"10.1159\/000083509"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"del Alc\u00e1zarViladomiu E, Lamas Dom\u00e9nech N, Salleras Redonnet M. Absolute versus relative Psoriasis Area and Severity Index in clinical practice. Actas Dermosifiliogr 2019; 110: 606-10;","DOI":"10.1016\/j.adengl.2018.03.021"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Coimbra S, Oliveira H, Reis F, Belo L, Rocha S, Quin - tanilha A, et al. Erythroid disturbances before and after treatment of Portuguese psoriasis vulgaris patients: a cross-sectional and longitudinal study. Am J Clin Der - matol 2012; 13: 37-47;","DOI":"10.2165\/11592110-000000000-00000"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Demir Pektas S, Pektas G, Tosun K, Dogan G, Neselio glu S, Erel O. Evaluation of erythroid disturbance and thioldisulphidehomeostasis in patients with psoriasis. Biomed Res Int 2018; 2018: 9548252;","DOI":"10.1155\/2018\/9548252"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Rocha-Pereira P, Santos-Silva A, Rebelo I, Figneiredo A, Quintanilha A, Teixeira F. Erythrocyte damage in mild and severe psoriasis. Br J Dermatol 2004; 150: 232-44;","DOI":"10.1111\/j.1365-2133.2004.05801.x"}],"container-title":["Journal of Medical Biochemistry"],"original-title":["Pove\u0107ana \u0161irina distribucije eritrocita kod pacijenata sa psorijazom tipa plaka"],"language":"en","link":[{"URL":"https:\/\/aseestant.ceon.rs\/index.php\/jomb\/article\/download\/27237\/16049","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/scindeks-clanci.ceon.rs\/data\/pdf\/1452-8258\/2021\/1452-82582102199G.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T20:44:13Z","timestamp":1615581853000},"score":1,"resource":{"primary":{"URL":"https:\/\/scindeks.ceon.rs\/Article.aspx?artid=1452-82582102199G"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.5937\/jomb0-27237","relation":{},"ISSN":["1452-8258","1452-8266"],"issn-type":[{"value":"1452-8258","type":"print"},{"value":"1452-8266","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]}}}