{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T14:23:20Z","timestamp":1740147800418,"version":"3.37.3"},"reference-count":20,"publisher":"Centre for Evaluation in Education and Science (CEON\/CEES)","issue":"4","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/BY\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Biochemistry"],"published-print":{"date-parts":[[2022]]},"abstract":"<jats:p>Background: COVID-19 may affect many endocrine tissues as well as thyroid gland and hypothalamus-pituitary-thyroid axis. It has been shown that COV D-19 infection suppresses thyroid hormones in some studies and causes subacute thyroiditis in the others so that its effects are still not fully known. The aim of our study is to retrospectively evaluate thyroid functions, clinical findings, biochemical and inflammatory markers in PCR positive patients infected with COVID-19; and to evaluate the relationship between abnormal thyroid function tests (TFT) and clinical and laboratory findings and whether it has potential prognostic significance. Methods: The data of patients aged 18 years and older, 201 patients who applied to Mersin City Training and Research Hospital due to COVID-19 infection between 1st of March and 1st of April in 2021 and received inpatient treatment were evaluated retrospectively Results: Large TFT (TSH, T3, T4, anti-TPO) and laboratory data of 201 patients with mild, moderate or severe pneumonia on CT were scanned retrospectively. 121 (60.2%) of the patients were male, mean age was 51.9 \u00b1 14.6 years, and the most common comorbid disease was hypertension in 65 (32.3%) patients. Conclusions: It has been determined that the deterioration in TFTs is associated with LDH and D-dimer which are indicators of cell and endothelial damage, duration of hospitalization, clinical severity, and having mutant strains and it has been concluded that low TSH can be used as a prognostic indicator in COVID-19 patients. Further studies with healthy control groups, quantitative RT-PCR tests, histological and pathological correlations, and long-term follow-up are needed.<\/jats:p>","DOI":"10.5937\/jomb0-34934","type":"journal-article","created":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T09:36:05Z","timestamp":1647423365000},"page":"491-496","source":"Crossref","is-referenced-by-count":4,"title":["Effects of covid-19 infection on thyroid functions"],"prefix":"10.5937","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9036-0135","authenticated-orcid":false,"given":"Deniz","family":"Gezer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7701-7826","authenticated-orcid":false,"suffix":"Seval","given":"M\u00fczeyyen","family":"Ecin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3964","reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Lui DTW, Lee CH, Chow WS, et al. 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Clin Endocrinol (Oxf). 2002; 57(1):51-8;","DOI":"10.1046\/j.1365-2265.2002.01558.x"},{"key":"ref12","unstructured":"Chinese National Health Commission. Chinese Clinical Guidance for COVID-19 Pneumonia Diagnosis and Treatment (7th edition). ProMED-mail website. http:\/\/kjfy.meetingchina. org\/msite\/news\/show\/cn\/ 3337.html. Accessed August 23, 2020;"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020; 395: 497;","DOI":"10.1016\/S0140-6736(20)30183-5"},{"key":"ref14","unstructured":"Richardson S, Hirsch JS, Narasimhan M, et al. Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized with COVID-19 in the New York City Area. JAMA 2020; 323: 2052;"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, Xiang J, Wang Y, Song B, Gu X, Guan L, Wei Y, Li H, Wu X, Xu J, Tu S, Zhang Y, Chen H, Cao B. Clinical Course and Risk Factors for Mortality of Adult Inpatients With COVID-19 in Wuhan, China: A Retrospective Cohort Study. Lancet 2020; 395: 1054-62;","DOI":"10.1016\/S0140-6736(20)30566-3"},{"key":"ref16","unstructured":"T.R. Ministry of Health COVID-19 (SARS-CoV-2 Infection) Management of severe pneumonia, ARDS, sepsis and septic shock, 7 November 2020;"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Brabant A, Brabant G, Schuermeyer T, Ranft U, Schmidt FW, et al. The role of glucocorticoids in the regulation of thyrotropin. Acta Endocrinol 1989; 121: 95-100;","DOI":"10.1530\/acta.0.1210095"},{"key":"ref18","unstructured":"Larsen PR, Davies TF, Schlumberger MJ, Hay IA. (2008). \"Thyroid Physiology and diagnostic evaluation of patients with thyroid disorders,\" in Williams Textbook of Endocrinology, ds Kronenberg HM, Melmed S, Polonsky KS, Larsen P R, (Philadelphia, PA: Saunders Elsevier), 442-99;"},{"key":"ref19","unstructured":"Dosi R, Jain G, Mehta A. Clinical characteristics, comorbidities, and outcome among 365 patients of coronavirus disease 2019 at tertiary carecentreincentral India. Jassoc Physicians India 2020; 68(9): 20-3;"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Teuwen LA, Geldhof V, Pasut A, Carmeliet P. COVID-19: the vasculature unleashed. Nat Rev Immunol 2020; 20: 389;","DOI":"10.1038\/s41577-020-0343-0"}],"container-title":["Journal of Medical Biochemistry"],"original-title":["Efekti Covid-19 infekcije na funkciju \u0161titne \u017elezde"],"language":"en","link":[{"URL":"https:\/\/aseestant.ceon.rs\/index.php\/jomb\/article\/download\/34934\/19812","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/scindeks-clanci.ceon.rs\/data\/pdf\/1452-8258\/2022\/1452-82582204491G.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,15]],"date-time":"2022-10-15T10:22:52Z","timestamp":1665829372000},"score":1,"resource":{"primary":{"URL":"https:\/\/scindeks.ceon.rs\/Article.aspx?artid=1452-82582204491G"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.5937\/jomb0-34934","relation":{},"ISSN":["1452-8258","1452-8266"],"issn-type":[{"type":"print","value":"1452-8258"},{"type":"electronic","value":"1452-8266"}],"subject":[],"published":{"date-parts":[[2022]]}}}