{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:26:23Z","timestamp":1759335983193},"reference-count":20,"publisher":"Centre for Evaluation in Education and Science (CEON\/CEES)","issue":"4","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/BY\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Biochemistry"],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:p>Background: This systematic literature review and meta-analysis investigated whether the red blood cell distribution (RDW) may predict survival outcomes in laryngeal cancer patients undergoing curative treatment. Methods: We conducted an electronic search in Medline and Scopus using the keywords \"red blood cell distribution width\" OR \"RDW\" AND \"laryngeal cancer\" OR \"larynx cancer\" OR \"laryngeal carcinoma\" OR \"larynx carcinoma,\" without time or language restrictions (up to February 2023), for identifying studies investigating the prognostic value of RDW in patients with any form of laryngeal cancer and with a primary endpoint that was set as survival rate and\/or disease-free survival between 1 and 10 years after curative treatment. The research was conducted according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) 2020 reporting checklist. Results: The digital search enabled us to identify five studies, that were finally included in our pooled analysis (survival rate and\/or disease-free survival covered a window between 2.7-8.3 years). In four of the five studies, an enhanced RDW value in laryngeal cancer patients undergoing surgical or radiation treatment was associated with poorer survival (range of odds ratio ORs, 2.28-10.44). In the pooled analysis, increased RDW conferred an over 3fold higher risk of dying during follow-up after curative treatment for laryngeal cancer (OR, 3.37; 95%CI, 1.41-8.10). Conclusion: RDW retains a clinically important prognostic value in patients with laryngeal cancer undergoing curative treatment. Clinicians could acknowledge this information for using a more aggressive therapy or setting narrower follow-up in laryngeal cancer patients with increased RDW values.<\/jats:p>","DOI":"10.5937\/jomb0-42947","type":"journal-article","created":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T10:12:26Z","timestamp":1691057546000},"page":"557-564","source":"Crossref","is-referenced-by-count":9,"title":["Red blood cell distribution width (RDW) is a significant predictor of survival in laryngeal cancer patients: Systematic literature review and meta-analysis"],"prefix":"10.5937","volume":"42","author":[{"given":"Riccardo","family":"Nocini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabian","family":"Sanchis-Gomar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Lippi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camilla","family":"Mattiuzzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3964","reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Mattiuzzi C, Lippi G. Cancer statistics: a comparison between World Health Organization (WHO) and Global Burden of Disease (GBD). Eur J Public Health 2020; 30: 1026-7;","DOI":"10.1093\/eurpub\/ckz216"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Nocini R, Molteni G, Mattiuzzi C, Lippi G. Updates on larynx cancer epidemiology. Chin J Cancer Res 2020; 32: 18-25;","DOI":"10.21147\/j.issn.1000-9604.2020.01.03"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Divakar P, Davies L. Trends in Incidence and Mortality of Larynx Cancer in the US. JAMA Otolaryngol Head Neck Surg 2023; 149: 34-41;","DOI":"10.1001\/jamaoto.2022.3636"},{"key":"ref4","unstructured":"Koroulakis A, Agarwal M. Laryngeal Cancer. Updated 2022 Mar 15. In: StatPearls Internet. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK526076;"},{"key":"ref5","unstructured":"American Society of Clinical Oncology. Laryngeal and Hypopharyngeal Cancer: Statistics. Available at: https:\/\/www.cancer.net\/cancer-types\/laryngeal-andhypopharyngeal-cancer\/statistics. Last accessed, February 20, 2023;"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Lippi G, Plebani M. Integrated diagnostics: the future of laboratory medicine? Biochem Med (Zagreb) 2020; 30: 010501;","DOI":"10.11613\/BM.2020.010501"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Bradford CR, Ferlito A, Devaney KO, M\u00e4kitie AA, Rinaldo A. Prognostic factors in laryngeal squamous cell carcinoma. Laryngoscope Investig Otolaryngol 2020; 5: 74-81;","DOI":"10.1002\/lio2.353"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Salvagno GL, Sanchis-Gomar F, Picanza A, Lippi G. Red blood cell distribution width: A simple parameter with multiple clinical applications. Crit Rev Clin Lab Sci 2015; 52: 86-105;","DOI":"10.3109\/10408363.2014.992064"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Montagnana M, Danese E. Red cell distribution width and cancer. Ann Transl Med 2016; (4): 399;","DOI":"10.21037\/atm.2016.10.50"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Hu L, Li M, Ding Y, Pu L, Liu J, Xie J, et al. Prognostic value of RDW in cancers: a systematic review and metaanalysis. Oncotarget 2017; 8: 16027-35;","DOI":"10.18632\/oncotarget.13784"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Wang PF, Song SY, Guo H, Wang TJ, Liu N, Yan CX. Prognostic role of pretreatment red blood cell distribution width in patients with cancer: A meta-analysis of 49 studies. J Cancer 2019; 10: 4305-17;","DOI":"10.7150\/jca.31598"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Kara M, Uysal S, Altini ik U, Cevizci S, G\u00fc\u00e7l\u00fc O, Derek\u00f6y FS. The pre-treatment neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and red cell distribution width predict prognosis in patients with laryngeal carcinoma. Eur Arch Otorhinolaryngol 2017; 274: 535-42;","DOI":"10.1007\/s00405-016-4250-8"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Bozkurt G, Korkut AY, Soyta P, Dizdar SK, Erol ZN. The role of red cell distribution width in the locoregional recurrence of laryngeal cancer. Braz J Otorhinolaryngol 2019; 85: 357-64;","DOI":"10.1016\/j.bjorl.2018.03.004"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Hsueh CY, Lau HC, Li S, Tao L, Zhang M, Gong H, et al. Pretreatment Level of Red Cell Distribution Width as a Prognostic Indicator for Survival in a Large Cohort Study of Male Laryngeal Squamous Carcinoma. Front Oncol 2019; 9: 271;","DOI":"10.3389\/fonc.2019.00271"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Staniewska E, Tomasik B, Tarnawski R, \u0141aszczych M, Miszczyk M. The prognostic value of red cell distribution width (RDW), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) in radiotherapy for oropharyngeal cancer. Rep Pract Oncol Radiother 2021; 26: 1010-8;","DOI":"10.5603\/RPOR.a2021.0126"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Marcus K, Sullivan CB, Al-Qurayshi Z, Buchakjian MR. Can Red Blood Cell Distribution Width Predict Laryngectomy Complications or Survival Outcomes? Ann Otol Rhinol Laryngol 2022; 131: 1102-8;","DOI":"10.1177\/00034894211056117"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Fu Y, Mao Y, Chen S, Yang A, Zhang Q. A Novel Inflammation-and Nutrition-Based Prognostic System for Patients with Laryngeal Squamous Cell Carcinoma: Combination of Red Blood Cell Distribution Width and Body Mass Index (COR-BMI). PLoS One 2016; 11: e0163282;","DOI":"10.1371\/journal.pone.0163282"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Shen LF, Wang QY, Yu Q. The Systemic Immune-Inflammation Index and Albumin as Prognostic Predictors in Laryngeal Carcinoma. Nutr Cancer 2021; 73: 1916-23;","DOI":"10.1080\/01635581.2020.1812677"},{"key":"ref19","unstructured":"Lippi G, Mattiuzzi C, Cervellin G. Learning more and spending less with neglected laboratory parameters: the paradigmatic case of red blood cell distribution width. Acta Biomed 2016; 87: 323-8;"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Lippi G, Plebani M. Red blood cell distribution width (RDW) and human pathology. One size fits all. Clin Chem Lab Med 2014; 52: 1247-9;","DOI":"10.1515\/cclm-2014-0585"}],"container-title":["Journal of Medical Biochemistry"],"original-title":["\u0160irina distribucije crvenih krvnih zrnaca (RDW) je zna\u010dajan prediktor pre\u017eivljavanja kod pacijenata sa rakom larinksa - sistematski pregled literature i meta-analiza"],"language":"en","link":[{"URL":"https:\/\/aseestant.ceon.rs\/index.php\/jomb\/article\/download\/42947\/23289","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/scindeks-clanci.ceon.rs\/data\/pdf\/1452-8258\/2023\/1452-82582304557N.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T20:09:11Z","timestamp":1698437351000},"score":1,"resource":{"primary":{"URL":"https:\/\/scindeks.ceon.rs\/Article.aspx?artid=1452-82582304557N"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.5937\/jomb0-42947","relation":{},"ISSN":["1452-8258","1452-8266"],"issn-type":[{"value":"1452-8258","type":"print"},{"value":"1452-8266","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]}}}