{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T17:20:28Z","timestamp":1785432028595,"version":"3.56.0"},"reference-count":33,"publisher":"Centre for Evaluation in Education and Science (CEON\/CEES)","issue":"4","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/BY\/4.0"}],"funder":[{"DOI":"10.13039\/501100004564","name":"Ministry of Education, Science and Technological Development of the Republic of Serbia","doi-asserted-by":"publisher","award":["41004"],"award-info":[{"award-number":["41004"]}],"id":[{"id":"10.13039\/501100004564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Biochemistry"],"published-print":{"date-parts":[[2024]]},"abstract":"<jats:p>Hemophagocytic lymphohistiocytosis (HLH) is a rare, lifethreatening hyperinflammatory disorder characterized by dysfunction of NK cells and cytotoxic lymphocytes. We present a rare case of a patient diagnosed with HLH who presented with persistent fever during treatment for refractory T-cell\/histiocyte-rich large B-cell lymphoma (TCHRLBCL), highlighting the challenges of managing HLH in the context of refractory lymphoma. According to our review of the literature, this is the first case of HLH that developed several months into treatment for refractory TCHRLBCL and not in close temporal relation to lymphoma diagnosis.<\/jats:p>","DOI":"10.5937\/jomb0-48290","type":"journal-article","created":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T04:22:52Z","timestamp":1704774172000},"page":"631-637","source":"Crossref","is-referenced-by-count":1,"title":["Unique presentation of T-cell\/histiocyte-rich large B cell lymphoma complicated with hemophagocytic lymphohistiocytosis: Case report and review of the literature"],"prefix":"10.5937","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6246-0198","authenticated-orcid":false,"given":"Andrej","family":"Pe\u0161i\u0107","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02122at02","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1069-8214","authenticated-orcid":false,"given":"Vojin","family":"Vukovi\u0107","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02122at02","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5949-3948","authenticated-orcid":false,"given":"Sofija","family":"Kozarac","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02122at02","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8690-1357","authenticated-orcid":false,"given":"Vladimir","family":"Ota\u0161evi\u0107","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02122at02","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Bibi\u0107","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02122at02","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5861-373X","authenticated-orcid":false,"given":"Biljana","family":"Mihaljevi\u0107","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02122at02","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2608-1342","authenticated-orcid":false,"given":"Darko","family":"Anti\u0107","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02122at02","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3964","reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Griffin G, Shenoi S, Hughes GC. Hemophagocytic lymphohistiocytosis: An update on pathogenesis, diagnosis, and therapy. Best Pract Res Clin Rheumatol 2020; 34: 101515;","DOI":"10.1016\/j.berh.2020.101515"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Usmani GN, Woda BA, Newburger PE. Advances in understanding the pathogenesis of HLH. Br J Haematol 2013; 161: 609-22;","DOI":"10.1111\/bjh.12293"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Esteban YM, de Jong JLO, Tesher MS. An Overview of Hemophagocytic Lymphohistiocytosis. Pediatr Ann 2017; 46: 309-13;","DOI":"10.3928\/19382359-20170717-01"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Bichon A, Bourenne J, Allardet-Servent J, Papazian L, Hraiech S, Guervilly C, et al. High Mortality of HLH in ICU Regardless Etiology or Treatment. Front Med (Lausanne) 2021; 8: 735796;","DOI":"10.3389\/fmed.2021.735796"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Jordan MB, Allen CE, Weitzman S, Filipovich AH, McClain KL. How I treat hemophagocytic lymphohistiocytosis. Blood 2011; 118: 4041-52;","DOI":"10.1182\/blood-2011-03-278127"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Chang TY, Jaffray J, Woda B, Newburger PE, Usmani GN. Hemophagocytic lymphohistiocytosis with MUNC13-4 gene mutation or reduced natural killer cell function prior to onset of childhood leukemia. Pediatr Blood Cancer 2011; 56: 856-8;","DOI":"10.1002\/pbc.22846"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Sukswai N, Lyapichev K, Khoury JD, Medeiros LJ. Diffuse large B-cell lymphoma variants: an update. Pathology 2020; 52: 53-67;","DOI":"10.1016\/j.pathol.2019.08.013"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Henter JI, Horne A, Aric\u00f3 M, Egeler RM, Filipovich AH, Imashuku S et al. HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer 2007; 48: 124-31;","DOI":"10.1002\/pbc.21039"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Voskoboinik I, Smyth MJ, Trapani JA. Perforin-mediated target-cell death and immune homeostasis. Nat Rev Immunol 2006; 6: 940-52;","DOI":"10.1038\/nri1983"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Han AR, Lee HR, Park BB, Hwang IG, Park S, Lee SC et al. Lymphoma-associated hemophagocytic syndrome: clinical features and treatment outcome. Ann Hematol 2007; 6: 493-8;","DOI":"10.1007\/s00277-007-0278-6"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Gupta A, Tyrrell P, Valani R, Benseler S, Weitzman S, Abdelhaleem M. The role of the initial bone marrow aspirate in the diagnosis of hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer 2008; 51: 402-4;","DOI":"10.1002\/pbc.21564"},{"key":"ref12","unstructured":"Goel S, Polski JM, Imran H. Sensitivity and specificity of bone marrow hemophagocytosis in hemophagocytic lymphohistiocytosis. Ann Clin Lab Sci 2012; 42: 21-5;"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Fardet L, Galicier L, Lambotte O, Marzac C, Aumont C, Chahwan D et al. Development and validation of the HScore, a score for the diagnosis of reactive hemophagocytic syndrome. Arthritis Rheumatol 2014; 66: 2613-20;","DOI":"10.1002\/art.38690"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Zhang K, Jordan MB, Marsh RA, Johnson JA, Kissell D, Meller J et al. Hypomorphic mutations in PRF1, MUNC13-4, and STXBP2 are associated with adultonset familial HLH. Blood 2011; 118: 5794-8;","DOI":"10.1182\/blood-2011-07-370148"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Clementi R, Dagna L, Dianzani U, Dupr\u00e9 L, Dianzani I, Ponzoni M et al. Inherited perforin and Fas mutations in a patient with autoimmune lymphoproliferative syndrome and lymphoma. 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Hemophagocytic lymphohistiocytosis complicating a T-cell rich B-cell lymphoma. BMC Hematol 2016; 16: 28;","DOI":"10.1186\/s12878-016-0065-5"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Devitt K, Cerny J, Switzer B, Ramanathan M, Nath R, Yu H et al. Hemophagocytic lymphohistiocytosis secondary to T-cell\/histiocyte-rich large B-cell lymphoma. Leuk Res Rep 2014; 3: 42-5;","DOI":"10.1016\/j.lrr.2014.05.004"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"Ibrahim U, Garcia G, Saqib A, Hussein S, Dai Q. T Cell Histiocyte Rich Large B Cell Lymphoma Presenting as Hemophagocytic Lymphohistiocytosis: An Uncommon Presentation of a Rare Disease. Case Rep Oncol Med 2017; 2017: 6428461;","DOI":"10.1155\/2017\/6428461"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Metts JL, Park SI, Briones MA, Keller FG. Hemophagocytic Lymphohistiocytosis Secondary to T Cell\/Histiocyte-rich Large B Cell Lymphoma in an Adolescent Male. 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J Cancer Res Clin Oncol 2020; 146: 3063-74;","DOI":"10.1007\/s00432-020-03301-y"},{"key":"ref33","doi-asserted-by":"crossref","unstructured":"Zhao L, Yang H, Qu WY, Lu YJ, Feng Z. Case report: Ruxolitinib plus dexamethasone as first-line therapy in haemophagocytic lymphohistiocytosis. Front Oncol 2023; 13: 1054175;","DOI":"10.3389\/fonc.2023.1054175"}],"container-title":["Journal of Medical Biochemistry"],"original-title":["Jedinstvena prezentacija \"T-cell\/histiocyte rich\" difuznog B krupno\u0107elijskog limfoma, komplikovanog hemofagocitnom limfohistiocitozom - prikaz slu\u010daja i pregled literature"],"language":"en","link":[{"URL":"https:\/\/aseestant.ceon.rs\/index.php\/jomb\/article\/download\/48290\/24419","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/scindeks-clanci.ceon.rs\/data\/pdf\/1452-8258\/2024\/1452-82582404631P.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T03:33:39Z","timestamp":1718422419000},"score":1,"resource":{"primary":{"URL":"https:\/\/scindeks.ceon.rs\/Article.aspx?artid=1452-82582404631P"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.5937\/jomb0-48290","relation":{},"ISSN":["1452-8258","1452-8266"],"issn-type":[{"value":"1452-8258","type":"print"},{"value":"1452-8266","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}