{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:37:16Z","timestamp":1791909436139,"version":"4.3.4"},"reference-count":22,"publisher":"Centre for Evaluation in Education and Science (CEON\/CEES)","issue":"5","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/BY\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Biochemistry"],"published-print":{"date-parts":[[2024]]},"abstract":"<jats:p>Background: This study aimed to explore the correlation between the Matrix Metalloproteinase-3 (MMP-3) 1171 5A\/6A gene polymorphism and susceptibility to Chronic Periodontitis (CP). Methods: Following the PRISMA guidelines, a systematic search was conducted across four electronic databases (PubMed, Embase, Web of Science, and Cochrane Library) without any time or language limitations. The selection criteria included case-control studies examining the association between the MMP-3 gene polymorphism and CP. The data were independently extracted and cross-checked by two reviewers. The Newcastle-Ottawa Scale (NOS) was used to assess the quality of the studies. Statistical heterogeneity and publication bias were assessed. Results: Five studies, published between 2004 and 2019, met the inclusion criteria for the meta-analysis. No significant association was observed between MMP-3 gene polymorphism and CP susceptibility across all subjects in the four gene models. However, subgroup analysis revealed significant differences based on genotyping methods and smoking habits. Using PCR-RFLP genotyping method, the allele and additive models showed a positive correlation with the risk of CP (5A vs 6A, OR=1.12, 95%CI (1.02\u010d 1.23); 5A5A vs 6A6A, OR=2.85, 95%CI (1.61\u010d4.86)). In contrast, using Sanger sequencing method, the 5A mutation appeared to reduce CP susceptibility (5A vs 6A, OR=0.77, 95%CI (0.67\u010d0.87); 5A5A vs 6A6A, OR= 0.20, 95%CI (0.09\u010d0.42)). Moreover, smoking habits appeared to modulate the risk. Among smokers, the 5A mutation increased susceptibility to CP, while among nonsmokers it decreased. Conclusions: While no significant correlation was found in the overall population, the stratified analysis revealed nuanced relationships contingent on genotyping methods and smoking habits.<\/jats:p>","DOI":"10.5937\/jomb0-49044","type":"journal-article","created":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T03:46:40Z","timestamp":1717991200000},"page":"655-663","source":"Crossref","is-referenced-by-count":4,"title":["Association between matrix metalloproteinase-3 gene polymorphism and susceptibility to chronic periodontitis: A systematic review and meta-analysis"],"prefix":"10.5937","volume":"43","author":[{"given":"Ankang","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisi","family":"Ai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingxue","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3964","reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Hascoet E, Blanchard F, Blin-Wakkach C, Guicheux J, Lesclous P, Cloitre A. 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