{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T19:04:52Z","timestamp":1788375892432,"version":"build-2803163510"},"reference-count":36,"publisher":"Centre for Evaluation in Education and Science (CEON\/CEES)","issue":"2","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/BY\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Biochemistry"],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:p>Background:We aimed to investigate the relationship between pre-delivery serum b-human chorionic gonado - tropin (b-HCG), fibrinogen (FIB), and homocysteine (HCY) with hypertensive disorder complicating pregnancy (HDCP). Methods: This was a case-control study. 200 HDCP patients and 150 normal pregnant women were selected as study subjects. Fasting cubital venous blood samples were collected to measure serum triglycerides (TG), total cholesterol (TC), high-density lipoprotein (HDL), and lowdensity lipoprotein (LDL), as well as b-HCG, FIB, and HCY levels. Pearson correlation analysis examined the relationship between b-HCG, FIB, HCY, and HDCP. Receiver operating characteristic (ROC) curve analysis evaluated the predictive value of these indicators for HDCP. Multiple logistic regression analysis identified risk factors (RFs) for HDCP. Results: Serum TG, TC, HDL, LDL, FIB, b-HCG, and HCY were greatly elevated in the HDCP group versus the control group (CG) (P&lt;0.05). Serum b-HCG, FIB, and HCY showed notable positive correlations with HDCP (r=0.935, 0.547, 0.811; P&lt;0.05), and the areas under the ROC curve (AUC) for predicting HDCP based on serum b-HCG, FIB, HCY, and their combination were 0.743, 0.659, 0.801, and 0.886, respectively (P&lt;0.05). Lipid indicators and serum levels of FIB, b-HCG, and HCY were RFs for HDCP. Conclusions: Pregnant women with HDCP exhibited markedly elevated serum lipid levels and FIB, b-HCG, and HCY levels before delivery, which can serve as predictive indicators for HDCP.<\/jats:p>","DOI":"10.5937\/jomb0-52483","type":"journal-article","created":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T08:19:10Z","timestamp":1730103550000},"page":"235-243","source":"Crossref","is-referenced-by-count":3,"title":["Predictive value of pre-delivery serum b-human chorionic gonadotropin, fibrinogen, and homocysteine for pregnancy-induced hypertension"],"prefix":"10.5937","volume":"44","author":[{"given":"Hani","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaomiao","family":"Zhuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3964","reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Metoki H, Iwama N, Hamada H, Satoh M, Murakami T, Ishikuro M, Obara T. Hypertensive disorders of pregnancy: definition, management, and out-of-office blood pressure measurement. Hypertension Research: Official Journal of the Japanese Society of Hypertension 2022; 45(8): 1298-309;","DOI":"10.1038\/s41440-022-00965-6"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Benschop L, Duvekot JJ, Roeters van Lennep JE. Future risk of cardiovascular disease risk factors and events in women after a hypertensive disorder of pregnancy. Heart 2019; 105(16): 1273-8;","DOI":"10.1136\/heartjnl-2018-313453"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Ritter HL Jr, Weiden PL. Unusual association of bone marrow necrosis, disseminated intravascular coagulation, and a rare 8;16 chromosomal translocation in an adult patient with acute nonlymphocytic leukemia. Cancer Genetics and Cytogenetics 1987; 24(2): 243-50;","DOI":"10.1016\/0165-4608(87)90105-1"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Shao Y, Gu S, Zhang X. Effects of nifedipine and labetalol combined with magnesium sulfate on blood pressure control, blood coagulation function, and maternal and infant outcome in patients with pregnancyinduced hypertension. Computational and Mathematical Methods in Medicine 2022; 2022: 9317114(1-8);","DOI":"10.1155\/2022\/9317114"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Takeda J, Takeda S. Management of disseminated intravascular coagulation associated with placental abruption and measures to improve outcomes. Obstetrics & Gynecology Science 2019; 62(5): 299-306;","DOI":"10.5468\/ogs.2019.62.5.299"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Kerns JL, Ti A, Aksel S, Lederle L, Sokoloff A, Steinauer J. Disseminated intravascular coagulation and hemorrhage after dilation and evacuation abortion for fetal death. Obstetrics and Gynecology, 2019; 134(4): 708-13;","DOI":"10.1097\/AOG.0000000000003460"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Olapeju B, Ahmed S, Hong X, Wang G, Summers A, Cheng TL, Burd I, Wang X. Maternal hypertensive disorders in pregnancy and postpartum plasma B vitamin and homocysteine profiles in a high-risk multiethnic U.S., population. Journal of Women's Health 2020; 29(12): 1520-9;","DOI":"10.1089\/jwh.2020.8420"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Hasija A, Balyan K, Debnath E, V R, Kumar M. Prediction of hypertension in pregnancy in high risk women using maternal factors and serial placental profile in second and third trimester. Placenta 2021; 104: 236-42;","DOI":"10.1016\/j.placenta.2021.01.005"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Chen Y, Ning W, Chu X, Chen Y, Gu L, Xie Z, Li L, Wen C, Wang X. Predicting hypertensive disease in the first trimester of pregnancy: risk models and analysis of serum d-dimer levels combined with plasma pregnancy-associated protein A, free b-subunit of human chorionic gonadotropin, and fetal nuchal translucency. Biomed Research International 2022; 2022: 8264958(1-13);","DOI":"10.1155\/2022\/8264958"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Chen Y, Chen Y, Wang X, Chu X, Ning W, Gu L, Li L, Xie Z, Wen C. Second trimester maternal serum D-dimer combined with alpha-fetoprotein and free b-subunit of human chorionic gonadotropin predict hypertensive disorders of pregnancy: a systematic review and retrospective case-control study. Journal of Translational Medicine 2021; 19(1): 94(1-12);","DOI":"10.1186\/s12967-021-02718-4"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Yadav R, Manisha, Shaheen R. Exploring the role of serum b-HCG levels in predicting hypertensive disorders of pregnancy: a prospective observational study. Int J Reprod Contracept Obstet Gynecol 2023; 12(8). doi: https:\/\/doi.or g\/10.18203\/2320-1770.ijr cog 20232296;","DOI":"10.18203\/2320-1770.ijrcog20232296"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Bhalerao AV, Dawle SS. Prediction of pregnancy-induced hypertension by maternal serum beta human chorionic gonadotropin levels in early second trimester of pregnancy. Journal of South Asian Federation of Obstetrics and Gynaecology. 2017 Jan 1; 10(2): 104-9;","DOI":"10.5005\/jp-journals-10006-1570"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Murmu S, Dwivedi J. Second-trimester maternal serum beta-human chorionic gonadotropin and lipid profile as a predictor of gestational hypertension, preeclampsia, and eclampsia: a prospective observational study. Inter - national Journal of Applied and Basic Medical Research 2020 Jan 1; 10(1): 49-53;","DOI":"10.4103\/ijabmr.IJABMR_271_19"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Sinkey RG, Battarbee AN, Bello NA, Ives CW, Oparil S, Tita ATN. Prevention, diagnosis, and management of hypertensive disorders of pregnancy: a comparison of international guidelines. Current Hypertension Reports 2020; 22(9): 66(1-16);","DOI":"10.1007\/s11906-020-01082-w"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Hosseini MS, Abtahi D, Tajbakhsh A, Farzaneh F, Sayadi S, Amjadi N, Hosseinzadeh M. Evaluation of the Differences in Plasma Fibrinogen Levels Before and After Cesarean Section and its Association with Intra-and Postoperative Bleeding. Journal of Obstetrics, Gyne cology and Cancer Research 2023 Feb 22; 8(2): 157-66;","DOI":"10.30699\/jogcr.8.2.157"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Wei J, Shen N, Shi C, Li N, Yin C, Feng Y, Lu H, Yang X, Zhou L. Exploration of serum lipid levels during twin pregnancy. The Journal of Maternal-fetal & Neonatal Medicine 2023; 36(2): 2254891(1-11);","DOI":"10.1080\/14767058.2023.2254891"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Reddy S, Jim B. Hypertension and pregnancy: management and future risks. Advances in Chronic Kidney Disease 2019; 26(2): 137-45;","DOI":"10.1053\/j.ackd.2019.03.017"},{"key":"ref18","unstructured":"Yang C, Wu H. Establishment and validation of risk prediction model for postpartum hemorrhage for pregnant women 35 years of age in natural delivery. Alternative Therapies in Health and Medicine 2023; 29(8): 876-81;"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Popescu NI, Lupu C, Lupu F. Disseminated intravascular coagulation and its immune mechanisms. Blood 2022; 139(13): 1973-86;","DOI":"10.1182\/blood.2020007208"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Alhousseini A, Romero R, Benshalom-Tirosh N, Gudicha D, Pacora P, Tirosh D, Kabiri D, Yeo L, Thachil J, Hsu CD, Hassan SS, Erez O. Nonovert disseminated intravascular coagulation (DIC) in pregnancy: a new scoring system for the identification of patients at risk for obstetrical hemorrhage requiring blood product transfusion. The Journal of Maternal-Fetal & Neonatal Medicine 2022; 35(2): 242-57;","DOI":"10.1080\/14767058.2020.1716330"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"Kamata M, Maruyama T, Nishiguchi T, Iwasaki S. Sudden onset of syncope and disseminated intravascular coagulation at 14 weeks of pregnancy: a case report. BMC Pregnancy and Childbirth 2020; 20(1): 406(1-5);","DOI":"10.1186\/s12884-020-03083-8"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Liu Z, Zhang H, Chen L, Lin L, Yan J. Blood coagulation indices in twin pregnancy complicated with preeclampsia. Journal of the College of Physicians and Surgeonspakistan: JCPSP 2020; 30(3): 276-81;","DOI":"10.29271\/jcpsp.2020.03.276"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"Li R, Mukherjee MB, Jin Z, Liu H, Lin K, Liu Q, Dilger JP, Lin J. The potential effect of general anesthetics in cancer surgery: meta-analysis of postoperative metastasis and inflammatory cytokines. Cancers (Basel) 2023; 15(10): 2759(1-14);","DOI":"10.3390\/cancers15102759"},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"Ou L, Liu HR, Shi XY, Peng C, Zou YJ, Jia JW, Li H, Zhu ZX, Wang YH, Su BM, Lai YQ, Chen MY, Zhu WX, Feng Z, Zhang GM, Yao MC. Terminalia chebula Retz. aqueous extract inhibits the Helicobacter pylori-induced inflammatory response by regulating the inflammasome signaling and ER-stress pathway. Journal of Ethno - pharma cology 2024; 320: 117428(1-14);","DOI":"10.1016\/j.jep.2023.117428"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"\u00c7\u00f6rt\u00fck M, Y\u0131ld\u0131zeli B, Kurar E, Kay\u0131 SA, Tanr\u0131verdi E, \u00c7etinkaya E. Fibrinogen-A THR312ALA polymorphism is associated tochronic thromboembolic pulmonary hypertension in turkey. The Anatolian Journal of Cardiology 2023; 27(3): 153-9;","DOI":"10.14744\/AnatolJCardiol.2022.2392"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Liu Y, Xiong M, Zhou F, Shi N, Jia Y. Effect of baicalin on gestational hypertension-induced vascular endothelial cell damage. The Journal of International Medical Research 2020; 48(10): 300060520934288(1-10);","DOI":"10.1177\/0300060520934288"},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"Cai H, Mol BW, Gordts S, Wang H, Wang T, Li N, Shi J. Early and late pregnancy loss in women with polycystic ovary syndrome undergoing IVF\/ICSI treatment: a retrospective cohort analysis of 21 820 pregnancies. BJOG: an International Journal of Obstetrics and Gynaecology 2021; 128(7): 1160-9;","DOI":"10.1111\/1471-0528.16590"},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"Skogler J, Moberg T, Tancredi L, Styrmisd\u00f3ttir L, Hedayati E, Alarcon-Ruiz CA, Khamis A, Persad E, Iskandarani G, Hansson SR, Bruschettini M. Association between human chorionic gonadotropin (hCG) levels and adverse pregnancy outcomes: a systematic review and metaanalysis. Pregnancy Hypertension 2023; 34: 124-37;","DOI":"10.1016\/j.preghy.2023.11.003"},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"Wang R, Chen L, Wang X, Liu Y. Association between serum beta-human chorionic gonadotropin and inflammation, oxidative stress in pregnancy-induced hypertension. Microvascular Research 2021; 135: 104130(1-6);","DOI":"10.1016\/j.mvr.2020.104130"},{"key":"ref30","doi-asserted-by":"crossref","unstructured":"Huang J, Liu Y, Yang H, Xu Y, Lv W. The effect of serum b-human chorionic gonadotropin on pregnancy complications and adverse pregnancy outcomes: a systematic review and meta-analysis. Computational and Mathe - matical Methods in Medicine 2022; 2022: 8315519(1-10);","DOI":"10.1155\/2022\/8315519"},{"key":"ref31","doi-asserted-by":"crossref","unstructured":"Kasoha M, Takacs Z, Dum\u00e9 J, Findeklee S, Gerlinger C, Sima RM, Ples L, Solomayer EF, Haj Hamoud B. Post - partum assessment of the correlation between serum hormone levels of estradiol, progesterone, prolactin and \u00df-HCG and blood pressure measurements in preeclampsia patients. Diagnostics (Basel) 2022; 12(7): 1700(1-13);","DOI":"10.3390\/diagnostics12071700"},{"key":"ref32","doi-asserted-by":"crossref","unstructured":"Dong L, Liu J, Qin Y, Yang WJ, Nie L, Liu HN, Hu QH, Sun Y, Cao WY. Relationship between ambulatory arterial stiffness index and the severity of angiographic atherosclerosis in patients with H-type hypertension and coronary artery disease. Clinical and Experimental Hyper - tension (New York, N.Y.: 1993), 2023; 45(1): 2228517(1-7);","DOI":"10.1080\/10641963.2023.2228517"},{"key":"ref33","doi-asserted-by":"crossref","unstructured":"Wei F, Ding Y, Ou J, Chen X, Li L, Zhou Q, Chen Q, Wang Q, Feng Y, Meng X. Accurate detection of hcy in human serum and two-photon visualization of atherosclerosis using a highly specific fluorescent probe. Analytical Chemistry 2023; 95(24): 9173-81;","DOI":"10.1021\/acs.analchem.2c05441"},{"key":"ref34","unstructured":"Zeng Y, Li M, Chen Y, Wang S. Homocysteine, endothelin-1 and nitric oxide in patients with hypertensive disorders complicating pregnancy. International Journal of Clinical and Experimental Pathology 2015; 8(11): 15275-9;"},{"key":"ref35","doi-asserted-by":"crossref","unstructured":"Wang Y, Zhang X, Han Y, Yan F, Wu R. Efficacy of combined medication of nifedipine and magnesium sulfate on gestational hypertension and the effect on PAPP-A, VEGF, NO, Hcy and vWF. Saudi Journal of Biological Sciences 2019; 26(8): 2043-7;","DOI":"10.1016\/j.sjbs.2019.08.012"},{"key":"ref36","doi-asserted-by":"crossref","unstructured":"Sayyah-Melli M, Ghorbanihaghjo A, Alizadeh M, Kazemi-Shishvan M, Ghojazadeh M, Bidadi S. The effect of high dose folic acid throughout pregnancy on homocysteine (Hcy) concentration and pre-eclampsia: a randomized clinical trial. PLoS One 2016; 11(5): e0154400(1-11);","DOI":"10.1371\/journal.pone.0154400"}],"container-title":["Journal of Medical Biochemistry"],"original-title":["Prediktivna vrednost pretporo\\ajnog serumskog b-ljudskog horionskog gonadotropina, fibrinogena i homocisteina za hipertenziju koja je posledica trudno\u0107e"],"language":"en","link":[{"URL":"https:\/\/aseestant.ceon.rs\/index.php\/jomb\/article\/download\/52483\/26234","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/scindeks-clanci.ceon.rs\/data\/pdf\/1452-8258\/2025\/1452-82582502235L.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T21:33:13Z","timestamp":1742592793000},"score":1,"resource":{"primary":{"URL":"https:\/\/scindeks.ceon.rs\/Article.aspx?artid=1452-82582502235L"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.5937\/jomb0-52483","relation":{},"ISSN":["1452-8258","1452-8266"],"issn-type":[{"value":"1452-8258","type":"print"},{"value":"1452-8266","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}