{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T08:44:51Z","timestamp":1780735491836,"version":"3.54.1"},"reference-count":18,"publisher":"Centre for Evaluation in Education and Science (CEON\/CEES)","issue":"3","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/BY\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Biochemistry"],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:p>Background: Polycystic ovary syndrome is a very common endocrine and metabolic disease in clinical practice. Most polycystic ovary syndrome patients are complicated with obesity, a condition associated with an elevated risk of long-term complications such as diabetes, hypertension, and endometrial cancer, seriously threatening the health of patients. The best way to treat this disease is to use drugs to promote ovulation, adjust the menstrual period, and restore pregnancy. However, the drugs used to treat obesity and polycystic ovary syndrome usually have entirely opposite effects, resulting in unsatisfactory rehabilitation. Methods: This study selected 102 obese or overweight PCOS patients treated in our hospital from July 2022 to July 2024 as the research subjects. Sex hormones: The levels of prolactin (PRL), testosterone (T), follicle-stimulating hormone (FSH), and luteinising hormone (LH) were measured by electrochemiluminescence. Inflammation: C-reactive protein (CRP), white blood cell count (WBC), and procalcitonin (PCT) were examined by an automated blood cell counter. 46 (control group) of the 102 were treated with a conventional treatment scheme, and the other 56 (experimental group) were intervened by nutritional intervention combined with vitamin D based on conventional treatment. Results: Both groups showed reductions in sex hormone levels after treatment, with the PRL, T, LH, and FSH in the experimental group being (5.12\u00b10.51) ng\/mL, (1.22\u00b10.32) ng\/mL, (9.14\u00b11.61) mIU\/mL, and (5.01\u00b10.42) mIU\/mL, respectively, all of which were lower compared with the control group (P&lt;0.05). Conclusions: In this study, we intervened obese polycystic ovary syndrome patients with nutritional or conventional intervention and found that compared with conventional treatment, the posture, blood glucose metabolism, and lipid function of the patients who received nutritional intervention were more significantly metabolised, and the levels of inflammatory factors were more effectively inhibited, indicating the high clinical application value of nutritional intervention in obese polycystic ovary syndrome.<\/jats:p>","DOI":"10.5937\/jomb0-53948","type":"journal-article","created":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T08:53:56Z","timestamp":1740387236000},"page":"595-602","source":"Crossref","is-referenced-by-count":2,"title":["Effect of nutritional intervention combined with vitamin D on glucose metabolism, sex hormones and inflammatory factors in patients with polycystic ovary syndrome"],"prefix":"10.5937","volume":"44","author":[{"given":"Xinqin","family":"Kang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3964","reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Sadeghi HM, Adeli I, Calina D, Docea AO, Mousavi T, Daniali M, et al. Polycystic Ovary Syndrome: A Comprehensive Review of Pathogenesis, Management, and Drug Repurposing. Int J Mol Sci 2022; 23(2);","DOI":"10.3390\/ijms23020583"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Azziz R. Polycystic Ovary Syndrome. Obstet Gynecol 2018; 132(2): 321-36;","DOI":"10.1097\/AOG.0000000000002698"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Alesi S, Ee C, Moran LJ, Rao V, Mousa A. Nutritional Supplements and Complementary Therapies in Polycystic Ovary Syndrome. Adv Nutr 2022; 13(4): 1243-66;","DOI":"10.1093\/advances\/nmab141"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Ortiz-Flores AE, Luque-Ramirez M, Escobar-Morreale HF. Polycystic ovary syndrome in adult women. Med Clin (Barc). 2019; 152(11): 450-7;","DOI":"10.1016\/j.medcle.2019.02.019"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Szczuko M, Kikut J, Szczuko U, Szydlowska I, Nawrocka-Rutkowska J, Zietek M, et al. Nutrition Strategy and Life Style in Polycystic Ovary Syndrome-Narrative Review. Nutrients 2021; 13(7);","DOI":"10.3390\/nu13072452"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Escobar-Morreale HF. Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment. Nat Rev Endocrinol 2018; 14(5): 270-84;","DOI":"10.1038\/nrendo.2018.24"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"American College of O, Gynecologists' Committee on Practice B-G. ACOG Practice Bulletin No. 194: Polycystic Ovary Syndrome. Obstet Gynecol 2018; 131(6): e157-e71;","DOI":"10.1097\/AOG.0000000000002656"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"DiVall S, Merjaneh L. Adolescent Polycystic Ovary Syndrome: An Update. Pediatr Ann 2019; 48(8): e304-e10;","DOI":"10.3928\/19382359-20190729-01"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Macut D, Bjekic-Macut J, Rahelic D, Doknic M. Insulin and the polycystic ovary syndrome. Diabetes Res Clin Pract 2017; 130: 163-70;","DOI":"10.1016\/j.diabres.2017.06.011"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Shang Y, Zhou H, Hu M, Feng H. Effect of Diet on Insulin Resistance in Polycystic Ovary Syndrome. J Clin Endocrinol Metab 2020; 105(10);","DOI":"10.1210\/clinem\/dgaa425"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Calcaterra V, Verduci E, Cena H, Magenes VC, Todisco CF, Tenuta E, et al. Polycystic Ovary Syndrome in Insulin-Resistant Adolescents with Obesity: The Role of Nutrition Therapy and Food Supplements as a Strategy to Protect Fertility. Nutrients 2021; 13(6);","DOI":"10.3390\/nu13061848"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Kazemi M, Kim JY, Wan C, Xiong JD, Michalak J, Xavier IB, et al. Comparison of dietary and physical activity behaviors in women with and without polycystic ovary syndrome: a systematic review and meta-analysis of 39 471 women. Hum Reprod Update 2022; 28(6): 910-55;","DOI":"10.1093\/humupd\/dmac023"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Che X, Chen Z, Liu M, Mo Z. Dietary Interventions: A Promising Treatment for Polycystic Ovary Syndrome. Ann Nutr Metab 2021; 77(6): 313-23;","DOI":"10.1159\/000519302"},{"key":"ref14","unstructured":"Szczuko M, Skowronek M, Zapalowska-Chwyc M, Starczewski A. Quantitative assessment of nutrition in patients with polycystic ovary syndrome (PCOS). Rocz Panstw Zakl Hig 2016; 67(4): 419-26;"},{"key":"ref15","unstructured":"Kiani AK, Donato K, Dhuli K, Stuppia L, Bertelli M. Dietary supplements for polycystic ovary syndrome. J Prev Med Hyg 2022; 63(2 Suppl 3): E206-E13;"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Barrea L, Arnone A, Annunziata G, Muscogiuri G, Laudisio D, Salzano C, et al. Adherence to the Mediterranean Diet, Dietary Patterns and Body Composition in Women with Polycystic Ovary Syndrome (PCOS). Nutrients 2019; 11(10);","DOI":"10.3390\/nu11102278"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Dabravolski SA, Nikiforov NG, Eid AH, Nedosugova LV, Starodubova AV, Popkova TV, et al. Mitochondrial Dysfunction and Chronic Inflammation in Polycystic Ovary Syndrome. Int J Mol Sci 2021; 22(8);","DOI":"10.3390\/ijms22083923"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Liu D, Gao X, Pan XF, Zhou T, Zhu C, Li F, et al. The hepato-ovarian axis: genetic evidence for a causal association between non-alcoholic fatty liver disease and polycystic ovary syndrome. BMC Med 2023; 21(1): 62;","DOI":"10.1186\/s12916-023-02775-0"}],"container-title":["Journal of Medical Biochemistry"],"original-title":["Uticaj nutritivne intervencije uz vitamin D na metabolizam glukoze, seksualne hormone i inflamatorne faktore kod pacijentkinja sa sindromom policisti\u010dnih jajnika"],"language":"en","link":[{"URL":"https:\/\/scindeks-clanci.ceon.rs\/data\/pdf\/1452-8258\/2025\/1452-82582503595K.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T16:49:11Z","timestamp":1749833351000},"score":1,"resource":{"primary":{"URL":"https:\/\/scindeks.ceon.rs\/Article.aspx?artid=1452-82582503595K"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.5937\/jomb0-53948","relation":{},"ISSN":["1452-8258","1452-8266"],"issn-type":[{"value":"1452-8258","type":"print"},{"value":"1452-8266","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}