{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T18:22:53Z","timestamp":1757614973068,"version":"3.44.0"},"reference-count":23,"publisher":"Centre for Evaluation in Education and Science (CEON\/CEES)","issue":"6","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/BY\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Biochemistry"],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:p>Background: Hyperbaric oxygen therapy is an important treatment method for early consciousness recovery and rehabilitation after brain trauma. In this study, we investigated the effects of hyperbaric oxygen combined with probiotics nutritional supplements (PNS) on patients with severe craniocerebral injury complicated with swallowing disorders in the Intensive care unit. Methods: Seventy-four patients with severe craniocerebral injury who received hyperbaric oxygen therapy in the ICU of our hospital from July 2020 to October 2023 were selected for retrospective analysis. Among them, 35 received conventional NS (control groups), and another 39 received PNS (research group). Inflammatory factors, T-lymphocyte subsets, and gastrointestinal mucosal function were compared between the two groups before and after treatment. In addition, patients' neurological function was assessed using the Glasgow Coma Scale (GCS), the Fugl-Meyer Assessment (FMA), and the National Institutes of Health Stroke Scale (NIHSS). Finally, the incidence of adverse effects between the two groups was counted. Results: Compared with the control group, the research group had lower NIHSS and inflammatory factors after treatment, while FMA and GCS were higher (P&lt;0.05). In addition, the study group's immune and gastrointestinal mucosal functions were better (P&lt;0.05). However, the two groups had no statistically significant difference in the safety comparison (P&gt;0.05).<\/jats:p>","DOI":"10.5937\/jomb0-54673","type":"journal-article","created":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T04:12:56Z","timestamp":1743394376000},"page":"1340-1346","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic value of CRP, PCT, and TNF-a, D-lactate, DAO, and endotoxin on survival of patients with severe craniocerebral injury"],"prefix":"10.5937","volume":"44","author":[{"given":"Ming","family":"Gong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3964","reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Kuo KW, Bacek LM, Taylor AR. Head Trauma. Vet Clin North Am Small Anim Pract 2018; 48(1): 111-28.;","DOI":"10.1016\/j.cvsm.2017.08.005"},{"key":"ref2","unstructured":"Gao Y, Li ZD, Zou DH, Ma HX, Chen YJ, Zhong LW. Parameterised Analysis of Craniocerebral Injury Caused by Fist. Fa Yi Xue Za Zhi 2021; 37(3): 344-50.;"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Tian J, Zhang C, Wang Q. Analysis of craniocerebral injury in facial collision accidents. PLoS One 2020; 15(10): e0240359.;","DOI":"10.1371\/journal.pone.0240359"},{"key":"ref4","unstructured":"Yang ZH, Yin XJ, Fu GY. The correlation between CT findings of diffuse axonal injury and the expression of neuronal aquaporin in patients with craniocerebral injury. Eur Rev Med Pharmacol Sci 2022; 26(18): 6871-8.;"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Harch PG, Andrews SR, Rowe CJ, Lischka JR, Townsend MH, Yu Q, et al. 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Brain Inj 2022; 36(5): 693-702.;","DOI":"10.1080\/02699052.2022.2033848"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Mehta R, trainee GP, Chinthapalli K, consultant n. Glasgow coma scale explained. BMJ 2019; 365: l1296.;","DOI":"10.1136\/bmj.l1296"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Gladstone DJ, Danells CJ, Black SE. The Fugl-Meyer assessment of motor recovery after stroke: a critical review of its measurement properties. Neurorehabil Neural Repair 2002; 16(3): 232-40.;","DOI":"10.1177\/154596802401105171"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Kwah LK, Diong J. National Institutes of Health Stroke Scale (NIHSS). J Physiother 2014; 60(1): 61.;","DOI":"10.1016\/j.jphys.2013.12.012"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Ablin JN, Lang E, Catalogna M, Aloush V, Hadanny A, Doenyas-Barak K, et al. Hyperbaric oxygen therapy compared to pharmacological intervention in fibromyalgia patients following traumatic brain injury: A randomised, controlled trial. PLoS One 2023; 18(3): e0282406.;","DOI":"10.1371\/journal.pone.0282406"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Jiang HS, Wang YZ. Super early cranial repair improves the prognosis of patients with craniocerebral injury. J Int Med Res 2020; 48(9): 300060520959485.;","DOI":"10.1177\/0300060520959485"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Yu J. Bifidobacterium triple viable powder\/capsule: How effective it is against gastrointestinal diseases? J Gastroenterol Hepatol 2023; 38(7): 1013-4.;","DOI":"10.1111\/jgh.16283"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Ren B, Ye H, Shan W, Tao X, Ye Z. Effect of Hyperbaric Oxygen Intervention on Oxidative Stress and Expression of Nerve Growth Factor in Patients with Craniocerebral Injury. J Inflamm Res 2023; 16: 4925-32.;","DOI":"10.2147\/JIR.S422790"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Alashram AR, Padua E, Romagnoli C, Annino G. Hyperbaric oxygen therapy for cognitive impairments in patients with traumatic brain injury: A systematic review. Appl Neuropsychol Adult 2023; 30(5): 602-13.;","DOI":"10.1080\/23279095.2022.2041418"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Bennett MH. Evidence brief: hyperbaric oxygen therapy (HBOT) for traumatic brain injury and\/or post-traumatic stress disorder. Diving Hyperb Med 2018; 48(2): 115.;","DOI":"10.28920\/dhm48.2.115"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"Zhang J, Wan S, Gui Q. Comparison of safety, effectiveness and serum inflammatory factor indexes of Saccharomyces boulardii versus Bifidobacterium triple viable in treating children with chronic diarrhea: a randomised trial. Transl Pediatr 2021; 10(6): 1677-85.;","DOI":"10.21037\/tp-21-195"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Platzer V, Perez G, Galinier A, Genestal M, Riu-Poulenc B, Gonzalez L, et al. Protein and micronutrient deficiencies in patients with radiation cystitis and outcome after hyperbaric oxygen therapy. Clin Nutr ESPEN 2018; 23: 141-7.;","DOI":"10.1016\/j.clnesp.2017.10.012"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"Feng JR, Wang F, Qiu X, McFarland LV, Chen PF, Zhou R, et al. Efficacy and safety of probiotic-supplemented triple therapy for eradication of Helicobacter pylori in children: a systematic review and network meta-analysis. Eur J Clin Pharmacol 2017; 73(10): 1199-208.;","DOI":"10.1007\/s00228-017-2291-6"}],"container-title":["Journal of Medical Biochemistry"],"original-title":["Prognosti\u010dka vrednost CRP , PCT , TNF-a, d-laktata, dao i endotoksina u pogledu pre\u017eivljavanja pacijenata sa te\u0161kom kraniocerebralnom povredom"],"language":"en","link":[{"URL":"https:\/\/scindeks-clanci.ceon.rs\/data\/pdf\/1452-8258\/2025\/1452-82582506340G.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T11:14:47Z","timestamp":1757070887000},"score":1,"resource":{"primary":{"URL":"https:\/\/scindeks.ceon.rs\/Article.aspx?artid=1452-82582506340G"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.5937\/jomb0-54673","relation":{},"ISSN":["1452-8258","1452-8266"],"issn-type":[{"type":"print","value":"1452-8258"},{"type":"electronic","value":"1452-8266"}],"subject":[],"published":{"date-parts":[[2025]]}}}