{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T11:36:02Z","timestamp":1787830562820,"version":"build-2784847793"},"reference-count":45,"publisher":"Centre for Evaluation in Education and Science (CEON\/CEES)","issue":"4","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/BY\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Biochemistry"],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:p>Background: To explore the predictive value of relevant detection indexes and pathological serum NLR, PLR, P53, and K67 levels in lymph node metastasis (LNM) in patients with early gastric cancer (EGC) after radical surgery. Methods: Clinical data of EGC patients (297 cases, all of whom underwent radical gastrectomy for gastric cancer) admitted to Sichuan Integrative Medicine Hospital from March 2019 to March 2024 were retrospectively included. The clinical data and pathological results were recorded and compared, and the related predictive factors were analysed. Results: There were 43 cases (14.48%) of postoperative LNM among the 297 EGC patients. The average number of lymph nodes detected in the LNM (-) group was 28.35 \u00b1 8.23, which was lower than in the LNM (+) group (33 \u00b1 15), *P* &lt; 0.01. Binary multivariate logistic regression analysis identified the following as significant predictors of postoperative LNM in EGC patients: tumour size (OR: 2.582, 95% CI: 1.205-5.534), depth of invasion (OR: 2.953, 95% CI: 1.327-6.573), vascular invasion (OR: 2.724, 95% CI: 1.241-5.976), neuroaggression (OR: 2.681, 95% CI: 1.139-6.311), differentiation type (OR: 2.426, 95% CI: 1.140-5.119), and P53 (OR: 3.133, 95% CI: 1.183-8.301), P&lt;0.05. The area under the ROC curve (AUC) for the model based on these indexes was 0.801. Compared with the LNM (-) group, the LNM (+) group had a lower overall survival rate at 1 and 2 years (P&lt;0.05). Conclusions: Clinically relevant detection indexes and pathological P53 levels in patients after EGC radical surgery have a good predictive effect on the occurrence of LNM, which can assist in formulating scientific and reasonable clinical treatment plans.<\/jats:p>","DOI":"10.5937\/jomb0-55634","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T08:36:02Z","timestamp":1741854962000},"page":"792-800","source":"Crossref","is-referenced-by-count":1,"title":["Prognostic value of serum NLR, PLR, P53, K67 level in lymph node metastasis of early gastric cancer"],"prefix":"10.5937","volume":"44","author":[{"given":"Xin","family":"Long","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingxi","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feifei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaojun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3964","reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Bray F , Ferlay J, Soerjomataram I, Siegel RL, Torre LA, and Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians 2018; 68(6): 394-424;","DOI":"10.3322\/caac.21492"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Colquhoun A, Arnold M, Ferlay J, Goodman KJ, Forman D, and Soerjomataram I. Global patterns of cardia and non-cardia gastric cancer incidence in 2012. Gut 2015; 64(12): 1881-8;","DOI":"10.1136\/gutjnl-2014-308915"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Japanese Gastric Cancer Association. Japanese classification of gastric carcinoma: 3rd English edition. Gastric Cancer 2011; 14(2): 101-12;","DOI":"10.1007\/s10120-011-0041-5"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Kamiya S, Takeuchi H, Nakahara T, Niihara M, Nakamura R, Takahashi T, Wada N, Kawakubo H, Saikawa Y, Omori T, Murakami K, and Kitagawa Y. Auxiliary diagnosis of lymph node metastasis in early gastric cancer using quantitative evaluation of sentinel node radioactivity. Gastric Cancer 2016; 19(4): 1080-7;","DOI":"10.1007\/s10120-015-0572-2"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Noh SH, Hyung WJ, and Cheong JH. Minimally invasive treatment for gastric cancer: approaches and selection process. Journal of Surgical Oncology 2005; 90(3): 188-93;","DOI":"10.1002\/jso.20228"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Lin JX, Wang ZK, Wang W , Desiderio J, Xie JW , Wang JB, Lu J, Chen QY, Cao LL, Lin M, Tu RH, Zheng CH, Li P , Parisi A, Zhou ZW , and Huang CM. Risk factors of lymph node metastasis or lymphovascular invasion for early gastric cancer: a practical and effective predictive model based on international multicenter data. BMC Cancer 2019; 19(1): 1048;","DOI":"10.1186\/s12885-019-6147-6"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Mu J, Jia Z, Y ao W , Song J, Cao X, Jiang J, and Wang Q. Predicting lymph node metastasis in early gastric cancer patients: development and validation of a model. Future Oncology 2019; 15(31): 3609-17;","DOI":"10.2217\/fon-2019-0377"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Wang YW, Zhu ML, Wang RF , Xue WJ, Zhu XR, Wang LF, and Zheng LZ. Predictable factors for lymph node metastasis in early gastric cancer: analysis of clinico-pathologic factors and biological markers. Tumour Biology 2016; 37(7): 8567-78;","DOI":"10.1007\/s13277-015-4721-3"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Wang R, Zhang Z, Li D, Wu N, Peng Z. Association analysis of apoptosis-related gene caspase3, Integrin a subunit 1 and glutathione sulfur transferase M1 gene polymorphisms and susceptibility to gastric cardia carcinoma. J Med Biochem 2023; 42 (3): 412-9;","DOI":"10.5937\/jomb0-37763"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Nagtegaal ID, Odze RD, Klimstra D, Paradis V , Rugge M, Schirmacher P , Washington KM, Carneiro F , Cree IA, and WHO Classification of Tumours Editorial Board. The 2019 WHO classification of tumours of the digestive system. Histopathology 2020; 76(2): 82-188;","DOI":"10.1111\/his.13975"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"T anaka S, Kashida H, Saito Y , Y ahagi N, Y amano H, Saito S, Hisabe T, Yao T, Watanabe M, Yoshida M, Saitoh Y, T suruta O, Sugihara KI, Igarashi M, T oyonaga T , Ajioka Y , Kusunoki M, Koike K, Fujimoto K, and Tajiri H. Japan Gastroenterological Endoscopy Society guidelines for colorectal endoscopic submucosal dissection\/endoscopic mucosal resection. Digestive Endoscopy 2020; 32(2): 219-39;","DOI":"10.1111\/den.13545"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Wang S, Xu L, Wang Q, Li J, Bai B, Li Z, Wu X, Yu P , Li X, and Yin J. Postoperative complications and prognosis after radical gastrectomy for gastric cancer: a systematic review and meta-analysis of observational studies. World Journal of Surgical Oncology 2019; 17(1): 52;","DOI":"10.1186\/s12957-019-1593-9"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Kim SM, Min BH, Ahn JH, Jung SH, An JY, Choi MG, Sohn TS, Bae JM, Kim S, Lee H, Lee JH, Kim YW, Ryu KW, Kim JJ, and Lee JH. Nomogram to predict lymph node metastasis in patients with early gastric cancer: a useful clinical tool to reduce gastrectomy after endoscopic resection. Endoscopy 2020; 52(6): 435-43;","DOI":"10.1055\/a-1117-3059"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Chen J, Zhao G, and Wang Y. Analysis of lymph node metastasis in early gastric cancer: a single institutional experience from China. World Journal of Surgical Oncology 2020; 18(1): 57;","DOI":"10.1186\/s12957-020-01834-7"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Gunji Y, Suzuki T, Hori S, Hayashi H, Matsubara H, Shimada H, and Ochiai T . Prognostic significance of the number of metastatic lymph nodes in early gastric cancer. Digestive Surgery 2003; 20(2): 148-53;","DOI":"10.1159\/000069392"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Du J, Shen Y , Yan W, and Wang J. Risk factors of lymph node metastasis in the splenic hilum of gastric cancer patients: a meta-analysis. World Journal of Surgical Oncology 2020; 18(1): 233;","DOI":"10.1186\/s12957-020-02008-1"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Dong D, Fang MJ, T ang L, Shan XH, Gao JB, Giganti F , Wang RP , Chen X, Wang XX, Palumbo D, Fu J, Li WC, Li J, Zhong LZ, De Cobelli F , Ji JF , Liu ZY , and Tian J. Deep learning radiomic nomogram can predict the number of lymph node metastasis in locally advanced gastric cancer: an international multicenter study. Annals of Oncology 2020; 31(7): 912-20;","DOI":"10.1016\/j.annonc.2020.04.003"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Wang Z, Liu J, Luo Y, Xu Y, Liu X, Wei L, and Zhu Q. Establishment and verification of a nomogram for predicting the risk of lymph node metastasis in early gastric cancer. Revista Espa\u00f1ola de Enfermedades Digestivas 2021; 113(6): 411-7;","DOI":"10.17235\/reed.2020.7102\/2020"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Sekiguchi M, Oda I, Taniguchi H, Suzuki H, Morita S, Fukagawa T, Sekine S, Kushima R, and Katai H. Risk stratification and predictive risk-scoring model for lymph node metastasis in early gastric cancer. Journal of Gastroenterology 2016; 51(10): 961-70;","DOI":"10.1007\/s00535-016-1180-6"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Pereira MA, Ramos M, Dias AR, Faraj SF, Yagi OK, Safatle-Ribeiro AV, Maluf-Filho F, Zilberstein B, Cecco-nello I, de Mello ES, and Ribeiro U Jr. Risk factors for lymph node metastasis in Western early gastric cancer after optimal surgical treatment. Journal of Gastrointestinal Surgery 2018; 22(1): 23-31;","DOI":"10.1007\/s11605-017-3517-8"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"Jin EH, Lee DH, Jung SA, Shim KN, Seo JY , Kim N, Shin CM, Y oon H, and Jung HC. Clinicopathologic factors and molecular markers related to lymph node metastasis in early gastric cancer. World Journal of Gastroenterology 2015; 21(2): 571-7;","DOI":"10.3748\/wjg.v21.i2.571"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Ronellenfitsch U, Lippert C, Grobholz R, Lang S, Post S, K\u00e4hler G, and Gaiser T. Histology-based prediction of lymph node metastases in early gastric cancer as decision guidance for endoscopic resection. Oncotarget 2016; 7(9): 10676-83;","DOI":"10.18632\/oncotarget.7221"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"Oh SY , Lee KG, Suh YS, Kim MA, Kong SH, Lee HJ, Kim WH, and Yang HK. Lymph node metastasis in mucosal gastric cancer: reappraisal of expanded indication of endoscopic submucosal dissection. Annals of Surgery 2017; 265(1): 137-42;","DOI":"10.1097\/SLA.0000000000001649"},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"Feng H, Wang Y, Cao L, Zhang C, Sun B, Zhao Y, and Xu J. Lymph node metastasis in differentiated-type early gastric cancer: a single-center retrospective analysis of surgically resected cases. Scandinavian Journal of Gastroenterology 2016; 51(1): 48-54;","DOI":"10.3109\/00365521.2015.1054425"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"Zhao B, Huang R, Lu H, Mei D, Bao S, Xu H, and Huang B. Risk of lymph node metastasis and prognostic outcome in early gastric cancer patients with mixed histologic type. Current Problems in Cancer 2020; 44(6): 100579;","DOI":"10.1016\/j.currproblcancer.2020.100579"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Karim S, and Ali A. Correlation of p53 over-expression and alteration in p53 gene detected by polymerase chain reaction-single strand conformation polymorphism in adenocarcinoma of gastric cancer patients from India. World Journal of Gastroenterology 2009; 15(11): 1381-7;","DOI":"10.3748\/wjg.15.1381"},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"Victorzon M, Nordling S, Haglund C, Lundin J, and Roberts PJ. Expression of p53 protein as a prognostic factor in patients with gastric cancer. European Journal of Cancer (Oxford, England: 1990) 1996; 32A(2): 215-20;","DOI":"10.1016\/0959-8049(95)00547-1"},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"Zhang Y, Zhao Q, Ren Y, Zhang P, and Zheng Y. Clinicopathological Significance and Molecular Mechanism of AKT\/GSK3b Pathway-based Fibrillin-1 Expression in Gastric Cancer Progression: AKT\/GSK3b in Gastric Cancer. Cell Mol Biol (Noisy-le-grand) 2022; 68(8): 57-63. Available from: https:\/\/www.cellmolbiol.org\/index.php\/CMB\/article\/view\/4493;","DOI":"10.14715\/cmb\/2022.68.8.10"},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"Xiao M, Zhang Z, Liao G, Liu M, and Chen X. Analysis of the Value of Helicobacter pylori Test in Combination with the Determination of Plasma Propepsin and Gastrin 17 in Screening the Precancerous Status of Gastric Cancer: H. pylori Test, Plasma Propepsin and Gastrin 17 in Gastric Cancer. Cell Mol Biol (Noisy-le-grand) 2022; 68(8): 110-5. Available from: https:\/\/www.cellmolbiol.org\/index.php\/CMB\/article\/view\/4503;","DOI":"10.14715\/cmb\/2022.68.8.20"},{"key":"ref30","doi-asserted-by":"crossref","unstructured":"Li M, Zheng G, Yu L, T an L-lian, Li X, Li M-J, Li C, Li S, Liang J, Zhong Z, and Li ZM. Diagnostic value of MRI-DWI signal intensity value combined with serum PGI, PGII and CA199 in early gastric cancer. Cell Mol Biol (Noisy-le-grand) 2021; 67(2): 95-100. Available from: https:\/\/www.cellmolbiol.org\/index.php\/CMB\/article\/view\/3980;","DOI":"10.14715\/cmb\/2021.67.2.14"},{"key":"ref31","doi-asserted-by":"crossref","unstructured":"He L, Zhou Y. Evaluation of increased microRNA-21 in the serum of patients with cardia cancer: MiR-21 in serum of cardia cancer patients. Cell Mol Biol (Noisy-le-grand) 2022; 68(4): 60-5. Available from: https:\/\/www.cellmolbiol.org\/index.php\/CMB\/article\/view\/4366;","DOI":"10.14715\/cmb\/2022.68.4.8"},{"key":"ref32","doi-asserted-by":"crossref","unstructured":"Dai Y , Y ang G, Y ang L, Jiang L, Zheng G, Pan S, and Zhu C. Expression of FOXA1 gene regulates the proliferation and invasion of human gastric cancer cells. Cell Mol Biol (Noisy-le-grand) 2021; 67(2): 161-5. Available from: https:\/\/www.cellmolbiol.org\/index.php\/CMB\/article\/view\/3991;","DOI":"10.14715\/cmb\/2021.67.2.25"},{"key":"ref33","doi-asserted-by":"crossref","unstructured":"Chen B, Zhang J, and Ma Q. The relationship between the simultaneity present of cagA and hopQI genes in Helicobacter pylori and the risk of gastric cancer. Cell Mol Biol (Noisy-le-grand) 2021; 67(2): 121-6. Available from: https:\/\/www.cellmolbiol.org\/index.php\/CMB\/article\/view\/3984;","DOI":"10.14715\/cmb\/2021.67.2.18"},{"key":"ref34","doi-asserted-by":"crossref","unstructured":"Guo X, Yin B, Wang C, Huo H, and Aziziaram Z. Risk assessment of gastric cancer in the presence of Helicobacter pylori cagA and hopQII genes. Cell Mol Biol (Noisy-le-grand) 2022; 67(4): 299-305. Available from: https:\/\/www.cellmolbiol.org\/index.php\/CMB\/article\/view\/4063;","DOI":"10.14715\/cmb\/2021.67.4.33"},{"key":"ref35","doi-asserted-by":"crossref","unstructured":"Zheng W, Tian X, Fan J, Jiang X, and He W. Application of Dexmedetomidine in Surgical Anesthesia for Gastric Cancer and Its Effects on IL-1b, IL-6, TNF-a, and CRP: Application of Dex in surgical anesthesia for gastric cancer. Cell Mol Biol (Noisy-le-grand) 2023; 69(3): 177-81. Available from: https:\/\/www.cellmolbiol.org\/index.php\/CMB\/article\/view\/4722;","DOI":"10.14715\/cmb\/2023.69.3.26"},{"key":"ref36","doi-asserted-by":"crossref","unstructured":"Zheng X, Chen P , Liu Y , Wang B, and Liu Q. Determining the relationship between cytokeratin expression and prognostic factors in human gastric cancer. Cell Mol Biol (Noisy-le-grand) 2022; 67(6): 311-7. Available from: https:\/\/www.cellmolbiol.org\/index.php\/CMB\/article\/view\/4184;","DOI":"10.14715\/cmb\/2021.67.6.41"},{"key":"ref37","doi-asserted-by":"crossref","unstructured":"Guo W, Jia L, Wang D, Wang Z, Li R, and Xue Z. Trop2 Promotes Vimentin Expression and Induces Epithelial Stromal Transformation, Invasion and Metastasis of Gastric Cancer Cells by Regulating b-Catenin: Trop2 Promotes Vimentin Expression. Cell Mol Biol (Noisy-le-grand) 2023; 69(1): 93-7. Available from: https:\/\/www.cellmolbiol.org\/index.php\/CMB\/article\/view\/4653;","DOI":"10.14715\/cmb\/2022.69.1.16"},{"key":"ref38","doi-asserted-by":"crossref","unstructured":"Tian X. Influences of Etomidate Combined with Propofol on Cognitive Function, Inflammation and Immunity in Patients Undergoing Gastric Cancer Surgery: Etomidate and Propofol on Gastric Cancer Surgery. Cell Mol Biol (Noisy-le-grand) 2023; 69(4): 81-5. Available from: https:\/\/www.cellmolbiol.org\/index.php\/CMB\/article\/view\/4744;","DOI":"10.14715\/cmb\/2023.69.4.12"},{"key":"ref39","doi-asserted-by":"crossref","unstructured":"Qi M, Liu D, Wang H, Bianba C, and Ji W. Relationship between glutathione S-transferase M1 gene polymorphism and gastric cancer: baijiaochui07143\u00aa163.com. Cell Mol Biol (Noisy-le-grand) 2022; 68(12): 49-53. Available from: https:\/\/www.cellmolbiol.org\/index.php\/CMB\/article\/view\/4626;","DOI":"10.14715\/cmb\/2022.68.12.10"},{"key":"ref40","doi-asserted-by":"crossref","unstructured":"Wang G, and Jiang X. Effect of PRECEDE-PROCEED-Model-Based Health Education on the Life Quality and 5-HTT Gene Expression of Patients with Gastric Cancer after Surgery. Cell Mol Biol (Noisy-le-grand) 2022; 67(6): 242-8. Available from: https:\/\/www.cellmolbiol.org\/index.php\/CMB\/article\/view\/4175;","DOI":"10.14715\/cmb\/2021.67.6.32"},{"key":"ref41","doi-asserted-by":"crossref","unstructured":"Ismail S, Naveed Mushtaq M, Shabbir U, Saima, Razzaq A, Ramzan HM, Shoukat A, Ahsan H, Movafagh A, Kahrizi D, and Anjum I. Evaluation of Hepatoprotective and Gastroprotective Activities of Paspalidium flavidum Leaves Extract in Experimental Animal Models: Hepatoand gastroprotective effect of Paspalidium flavidum. Cell Mol Biol (Noisy-le-grand) 2022; 68(10): 8-14. Available from: https:\/\/www.cellmolbiol.org\/index.php\/CMB\/article\/view\/4555;","DOI":"10.14715\/cmb\/2022.68.10.2"},{"key":"ref42","unstructured":"Kazemi E, and Kahrizi D. The repeatability of PCR-RFLP method for study of association between gastric cancer and manganese superoxide dismutase mutant (Val-9Ala). Biharean Biologist 2017; 11(2): 112-4;"},{"key":"ref43","doi-asserted-by":"crossref","unstructured":"Kazemi E, and Kahrizi D. Lack of association between gastric cancer and hopq alleles in Helicobacter pylori. Genetika 2016; 48(3): 893-902. https:\/\/doi.org\/10.2298\/gensr1603893k;","DOI":"10.2298\/GENSR1603893K"},{"key":"ref44","unstructured":"Kazemi E, Kahrizi D, Moradi MT , Sohrabi M, and Y ari K. Gastric Cancer and Helicobacter pylori: Impact of hopQII Gene. Cellular and Molecular Biology 2016; 62(2): 107-10. https:\/\/doi.10.14715\/cmb\/2016.62.2.18;"},{"key":"ref45","unstructured":"Kazemi E, Kahrizi D, Moradi MT, Sohrabi M, Amini A, Mousavi SAR, and Yari K. Association between Helicobacter pylori hopQI genotyping and human gastric cancer. Cellular and Molecular Biology 2016; 62(1): 6-9. https:\/\/doi.10.14715\/cmb\/2016.62.2.18;"}],"container-title":["Journal of Medical Biochemistry"],"original-title":["Prognosti\u010dka vrednost nivoa NLR, PLR, P53 i K67 u serumu kod limfne metastaze ranog karcinoma \u017eeluca"],"language":"en","link":[{"URL":"https:\/\/scindeks-clanci.ceon.rs\/data\/pdf\/1452-8258\/2025\/1452-82582504792L.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T14:50:17Z","timestamp":1751640617000},"score":1,"resource":{"primary":{"URL":"https:\/\/scindeks.ceon.rs\/Article.aspx?artid=1452-82582504792L"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":45,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.5937\/jomb0-55634","relation":{},"ISSN":["1452-8258","1452-8266"],"issn-type":[{"value":"1452-8258","type":"print"},{"value":"1452-8266","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}