{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T12:49:25Z","timestamp":1789130965402,"version":"build-2803163510"},"reference-count":22,"publisher":"Centre for Evaluation in Education and Science (CEON\/CEES)","issue":"5","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/BY\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Biochemistry"],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:p>Background: Acute ischemic stroke (AIS) often leads to hemiplegia, significantly impairing neurological function, motor ability, and daily life activities. Early precision exercise rehabilitation has emerged as a promising intervention to enhance recovery. This study evaluated its effectiveness in improving neurological function, gait performance, and self-care ability and reducing inflammatory response in hemiplegic patients. Methods: This retrospective cohort study included 230 patients with hemiplegia due to AIS, admitted within 72 hours of onset. Patients were divided into an Early Rehabilitation Group (EG, n = 132) and a Conventional Rehabilitation Group (CG, n = 98) based on the intervention received. The EG underwent early precision exercise rehabilitation, integrating neurofunctional training, motor-evoked potential (MEP) therapy, and functional electrical stimulation (FES), while the CG received traditional rehabilitation. The effectiveness was assessed using the National Institutes of Health Stroke Scale (NIHSS), Wisconsin Gait Scale (WGS), and Activities of Daily Living (ADL) scores. Serum inflammatory markers (TNF-a, hs-CRP IL-6, IL-18) were also measured before and after treatment. Results: The EG demonstrated significantly more significant improvements in NIHSS (5.85\u00b1 1.31 vs 7.03\u00b1 2.54, P&lt; 0.05), WGS (24.81\u00b1 3.06 vs. 31 .96 \u00b1 4.62 , P&lt; 0.05), and ADL scores (63.08\u00b1 4.93 vs. 51 .78 \u00b1 6.34 , P&lt; 0.05) compared to the CG. Walking frequency and speed were also higher in the EG (P&lt; 0.05). Inflammatory markers significantly decreased post-treatment in the EG (TNF-a: P&lt; 0.05, hs-CRP: P&lt; 0.05, IL-6: P&lt; 0.05, IL-18: P&lt; 0.05), suggesting a reduction in systemic inflammation. Conclusions: Early precision exercise rehabilitation significantly enhances neurological function, motor ability, and self-care capacity, reducing inflammatory response in hemiplegic AIS patients. These findings support its integration into clinical stroke rehabilitation protocols.<\/jats:p>","DOI":"10.5937\/jomb0-55968","type":"journal-article","created":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T04:17:45Z","timestamp":1742789865000},"page":"994-1002","source":"Crossref","is-referenced-by-count":1,"title":["The changes of serum inflammatory cytokines in patients with hemiplegia after ischemic stroke and the rehabilitation effects"],"prefix":"10.5937","volume":"44","author":[{"given":"Hongxia","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunqi","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3964","reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"DeLong JH, Ohashi SN, O'Connor KC, Sansing LH. Inflammatory Responses After Ischemic Stroke. 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Cellular Signalling 2023; 104: 110586;","DOI":"10.1016\/j.cellsig.2022.110586"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Zhang J, Ling L, Xiang L, Li W, Bao P Yue W. Role of the gut microbiota in complications after ischemic stroke. Front Cell Infect Microbiol 2024; 14: 1334581;","DOI":"10.3389\/fcimb.2024.1334581"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Sun F Zhou J, Chen X, Yang T, Wang G, Ge J, et al. No-reflow after recanalisation in ischemic stroke: From pathomechanisms to therapeutic strategies. J Cereb Blood Flow Metab 2024; 44(6): 857-80;","DOI":"10.1177\/0271678X241237159"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Li L, Shi C, Dong F Xu G, Lei M, Zhang F Targeting pyroptosis to treat ischemic stroke: From molecular pathways to treatment strategy. 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CNS Neurosci Ther 2024; 30(7): e14865-e;","DOI":"10.1111\/cns.14865"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Lu W, Wang Y Wen J. The Roles of RhoA\/ROCK\/NF-kB Pathway in Microglia Polarization Following Ischemic Stroke. Journal of Neuroimmune Pharmacology 2024; 19(1);","DOI":"10.1007\/s11481-024-10118-w"}],"container-title":["Journal of Medical Biochemistry"],"original-title":["Promene serumskih inflamatornih citokina kod pacijenata sa hemiplegijom nakon ishemijskog mo\u017edanog udara i efekti rehabilitacije"],"language":"en","link":[{"URL":"https:\/\/scindeks-clanci.ceon.rs\/data\/pdf\/1452-8258\/2025\/1452-82582505994L.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T13:52:27Z","timestamp":1755784347000},"score":1,"resource":{"primary":{"URL":"https:\/\/scindeks.ceon.rs\/Article.aspx?artid=1452-82582505994L"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.5937\/jomb0-55968","relation":{},"ISSN":["1452-8258","1452-8266"],"issn-type":[{"value":"1452-8258","type":"print"},{"value":"1452-8266","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}