{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T19:07:26Z","timestamp":1785784046931,"version":"3.56.0"},"reference-count":32,"publisher":"Centre for Evaluation in Education and Science (CEON\/CEES)","issue":"7","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/BY\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Biochemistry"],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:p>Background: The study aimed to demonstrate the impact of traditional Chinese medicine (TCM) matrine combined with omeprazole enteric-coated tablets on gastric mucosal histopathology, gastric function, inflammatory cytokines, and Helicobacter pylori (H. pylori) eradication in patients with chronic atrophic gastritis (CAG). Methods: A retrospective collection of case data from 110 patients with CAG admitted to the TCM Department of the hospital was conducted. Patients were rolled into the test group (TG, matrine + omeprazole enteric-coated tablets) and the control group (CG, omeprazole enteric-coated tablets). The gastric mucosal histopathological scores, serological indicators (interleukin (IL)-2, IL-10, tumour necrosis factor (TNF-a), gastric function (motilin (MTL), gastrin (GAS), pepsinogen (PG)), H. pylori eradication rate, and clinical efficacy were compared. Results: The degree of glandular atrophy, intestinal meta-plasia, dysplasia, and inflammatory activity index in patients of TG post-treatment were lower than CG (P&amp;lt;0.05). Post-treatment, IL-2, IL-10, and TNF-a levels in patients of TG were inferior to CG (P&amp;lt;0.05), and the H. pylori eradication rate in patients of TG (87.27%) was inferior to CG (63.64%) (P&amp;lt;0.05). The effective treatment rate in patients of TG post-treatment (92.73%) was higher than CG (78.18%) (P&amp;lt;0.05). Conclusions: Matrine combined with omeprazole enteric-coated tablets significantly improved gastric mucosal histopathology, reduced inflammatory cytokine levels, enhanced gastric function, and increased the H. pylori eradication rate compared to omeprazole monotherapy.<\/jats:p>","DOI":"10.5937\/jomb0-56027","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T04:03:52Z","timestamp":1745899432000},"page":"1505-1514","source":"Crossref","is-referenced-by-count":1,"title":["Serum level of (interleukin (IL)-2, IL-10, tumor necrosis factor (TNF)-a, motilin (MTL), gastrin (GAS), pepsinogen (PG), after adjunctive treatment in patients with chronic atrophic gastritis"],"prefix":"10.5937","volume":"44","author":[{"given":"Pan","family":"Xue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3964","reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Coles M, Madray V , Cox K, Uy P , Sharma A. 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