{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T21:15:10Z","timestamp":1772226910159,"version":"3.50.1"},"reference-count":30,"publisher":"Centre for Evaluation in Education and Science (CEON\/CEES)","issue":"2","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/BY\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Biochemistry"],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:p>Background: To analyse the changes in serum superoxide dismutase (SOD), malondialdehyde (MDA), IL-6, IL-8, TNF-a, and serum immune markers in patients with gastrointestinal bleeding (GIB) after allogeneic blood transfusion (ABT) during surgery. Methods: 80 patients with GIB requiring surgical treatment were enrolled. The experimental group (EG, n=40) received 2-4 U of red blood cells during surgery, while the control group (CG, n=40) did not. T cell subsets, natural killer cells (N KC), immunoglobulin, serum inflammatory factors, platelet count, oxidative stress indicators, and hemostasis time were measured before and 1 day after ABT. Results: In the EG, NKC, CD 3+, CD 4+, and CD 4+\/CD8+ decreased, IgG decreased, IL-6, IL-8, and TNF-a increased 1 day after ABT, while IgA, IgM, and platelet count remained unchanged. The EG showed a tremendous increase in SOD, a more significant decrease in MDA, and shorter hemostasis time and time for occult blood to become negative compared to the CG. Conclusions: ABT was effective in treating GIB but had an inhibitory effect on immune function. ABT did not affect platelet function but significantly changed oxidative stress indicators, inhibiting the peroxide response in GIB patients.<\/jats:p>","DOI":"10.5937\/jomb0-56287","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T03:10:30Z","timestamp":1743736230000},"page":"253-260","source":"Crossref","is-referenced-by-count":0,"title":["Serum superoxide dismutase (SOD), malondialdehyde (MDA), IL-6, IL-8, TNF-a, serum immune markers after allogeneic blood transfusion in patients with gastrointestinal bleeding"],"prefix":"10.5937","volume":"45","author":[{"given":"Lingling","family":"Wu","sequence":"first","affiliation":[{"name":"Fujian Medical University Affiliated Quanzhou First Hospital Chengdong Branch, Department of Hematology, Quanzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zaikai","family":"Lin","sequence":"additional","affiliation":[{"name":"Jing'An District Centre Hospital of Shanghai (Huashan Hospital Fudan University Jing'An Branch), Department of General Surgery, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jintu","family":"Chen","sequence":"additional","affiliation":[{"name":"Quanzhou First Hospital Affiliated to Fujian Medical University, Department of Clinical Laboratory, Quanzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yilan","family":"Sheng","sequence":"additional","affiliation":[{"name":"Fujian Medical University Affiliated Quanzhou First Hospital Chengdong Branch, Department of Hematology, Quanzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3964","reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Holster I, Kuipers E, Tjwa E. Hemospray in the treatment of upper gastrointestinal hemorrhage in patients on antithrombotic therapy. Endoscopy 2012; 45(01): 63-6;","DOI":"10.1055\/s-0032-1325793"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Mannami T, Fujiwara N, Ikeda G, Mishima T, Kuroi T, Muraoka T, et al. Gastrointestinal hemorrhage caused by the direct invasion of a hepatocellular carcinoma successfully treated with polyglycolic acid sheet shielding. Endoscopy 2018; 51(02): E20-E1;","DOI":"10.1055\/a-0747-5467"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Kably IM, Ziga ED, Andreansky M. Intra-Arterial Platelet Infusion for Intractable Hemorrhage and Refractory. Pediatric Blood & Cancer 2015; 62(12): 2226-8;","DOI":"10.1002\/pbc.25633"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Zhou P-L, Wu G, Han X-W, Yan L, Zhang W-G. Budd-Chiari syndrome with upper gastrointestinal hemorrhage: Characteristic and long-term outcomes of endovascular treatment. Vascular 2017; 25(6): 642-8;","DOI":"10.1177\/1708538117710087"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Otani K, Watanabe T, Shimada S, Hosomi S, Nagami Y, Tanaka F, et al. Clinical Utility of Capsule Endoscopy and Double-Balloon Enteroscopy in the Management of Obscure Gastrointestinal Bleeding. Digestion 2018; 97(1): 52-8;","DOI":"10.1159\/000484218"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Mullady DK, Wang AY, Waschke KA. AGA Clinical Practice Update on Endoscopic Therapies for Non-Variceal Upper Gastrointestinal Bleeding: Expert Review. Gastroenterology 2020; 159(3): 1120-8;","DOI":"10.1053\/j.gastro.2020.05.095"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Ray WA, Chung CP, Murray KT, Smalley WE, Daugherty JR, Dupont WD, et al. Association of Oral Anticoagulants and Proton Pump Inhibitor Cotherapy With Hospitalization for Upper Gastrointestinal Tract Bleeding. JAMA 2018; 320(21): 2221-30;","DOI":"10.1001\/jama.2018.17242"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"lower gastrointestinal bleeding: guidelines from the British Society of Gastroenterology. Gut 2019; 68(5): 776-89;","DOI":"10.1136\/gutjnl-2018-317807"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Patel SD, Desai R, Patel U, Singh S, Patel Z, Patel N, et al. Thirty-Day Readmissions After Upper and Lower Gastrointestinal Hemorrhage. Journal of Clinical Gastroenterology 2019; 53(8): 582-90;","DOI":"10.1097\/MCG.0000000000001020"},{"key":"ref10","unstructured":"Miura Y, Iwamoto F Ishida Y Kuno T, Tanaka K, Kobayashi S, et al. Refractory eosinophilic gastroenteritis with gastritis, duodenal ulcer, and colitis: a case report. Nihon Shokakibyo Gakkai Zasshi. The Japanese Journal of Gastro-enterology 2019; 116(8): 668-75;"},{"key":"ref11","unstructured":"Roberts I, Shakur-Still H, Afolabi A, Akere A, Arribas M, Brenner A, et al. Effects of a high-dose 24-h infusion of tranexamic acid on death and thromboembolic events in patients with acute gastrointestinal bleeding (HALT-IT): an international randomised, double-blind, placebo-controlled trial. The Lancet 2020; 395(10241): 1927-36;"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Barkun AN, Almadi M, Kuipers EJ, Laine L, Sung J, Tse F, et al. Management of Nonvariceal Upper Gastrointestinal Bleeding: Guideline Recommendations From the International Consensus Group. Ann Intern Med 2019; 171(11): 805-22;","DOI":"10.7326\/M19-1795"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Carson JL, Stanworth SJ, Roubinian N, Fergusson DA, Triulzi D, Doree C, et al. Transfusion thresholds and other strategies for guiding allogeneic red blood cell transfusion. The Cochrane database of systematic reviews 2016; 10(10): CD002042-CD;","DOI":"10.1002\/14651858.CD002042.pub4"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Nakanishi K, Kanda M, Kodera Y Long-lasting discussion: Adverse effects of intraoperative blood loss and allogeneic transfusion on prognosis of patients with gastric cancer. World Journal of Gastroenterology 2019; 25(22): 2743-51;","DOI":"10.3748\/wjg.v25.i22.2743"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Alzoubaidi D, Hussein M, Rusu R, Napier D, Dixon S, Rey JW, et al. Outcomes from an international multicenter registry of patients with acute gastrointestinal bleeding undergoing endoscopic treatment with Hemospray. Digestive Endoscopy 2019; 32(1): 96-105;","DOI":"10.1111\/den.13502"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Lee S-R, Kwon S, Choi E-K, Jung J-H, Han K-D, Oh S, et al. Proton Pump Inhibitor Co-Therapy in Patients with Atrial Fibrillation Treated with Oral Anticoagulants and a Prior History of Upper Gastrointestinal Tract Bleeding. Cardiovascular Drugs and Therapy 2021; 36(4): 679-89;","DOI":"10.1007\/s10557-021-07170-6"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Boateng LA, Ngoma AM, Bates I, Schonewille H. Red Blood Cell Alloimmunization in Transfused Patients With Sickle Cell Disease in Sub-Saharan Africa; a Systematic Review and Meta-Analysis. Transfusion Medicine Reviews 2019; 33(3): 162-9;","DOI":"10.1016\/j.tmrv.2019.06.003"},{"key":"ref18","unstructured":"Mukhopadhyay B, Gavel R, Gongopadhyay AN, Vashistha P Rani A, Mishra SP Correlation of Oxidative Damage with Pro-Inflammatory Markers (IL-6, TNF-a) in Meningocele. Journal of Clinical and Diagnostic Research: JCDR 2016; 10(2): Bc08-10;"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Barinov A, Galgano A, Krenn G, Tanchot C, Vasseur F Rocha B. CD4\/CD8\/Dendritic cell complexes in the spleen: CD8+ T cells can directly bind CD4+ T cells and modulate their response. PLoS One 2017; 12(7): e0180644-e;","DOI":"10.1371\/journal.pone.0180644"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Bian Z, Liu J, Xu LP Chang YJ, Wang Y, Zhang XH , et al. Association of Epstein-Barr virus reactivation with the recovery of CD4\/CD8 double-negative T lymphocytes after haploidentical hematopoietic stem cell transplantation. Bone Marrow Transplantation 2016; 52(2): 264-9;","DOI":"10.1038\/bmt.2016.238"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"Carlsten M, Jar\u00e2s M. Natural Killer Cells in Myeloid Malignancies: Immune Surveillance, NK Cell Dysfunction, and Pharmacological Opportunities to Bolster the Endogenous NK Cells. Front Immunol 2019; 10: 2357;","DOI":"10.3389\/fimmu.2019.02357"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Rosenne E, Shakhar G, Melamed R, Schwartz Y, Erdreich-Epstein A, Ben-Eliyahu S. Inducing a mode of NK-resistance to suppression by stress and surgery: a potential approach based on low dose of poly I-C to reduce postoperative cancer metastasis. Brain, Behavior, and Immunity 2007; 21(4): 395-408;","DOI":"10.1016\/j.bbi.2006.12.002"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"Gruber DR, Richards AL, Howie HL, Hay AM, Lebedev JN, Wang X , et al. Passively transferred IgG enhances humoral immunity to a red blood cell alloantigen in mice. Blood Adv 2020; 4(7): 1526-37;","DOI":"10.1182\/bloodadvances.2019001299"},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"Satoh-Takayama N, Kato T, Motomura Y, Kageyama T, Taguchi-Atarashi N, Kinoshita-Daitoku R, et al. Bacteria-Induced Group 2 Innate Lymphoid Cells in the Stomach Provide Immune Protection through Induction of IgA. Immunity 2020; 52(4): 635-49.e4;","DOI":"10.1016\/j.immuni.2020.03.002"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"Caviglia GP Rosso C, Stalla F, Rizzo M, Massano A, Abate ML, et al. On-Treatment Decrease of Serum Interleukin-6 as a Predictor of Clinical Response to Biologic Therapy in Patients with Inflammatory Bowel Diseases. J Clin Med 2020; 9(3): 800;","DOI":"10.3390\/jcm9030800"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Gupta K, Khan A, Kumar M, Sawalha K, Abozenah M, Singhania R. Readmissions Rates After Myocardial Infarction for Gastrointestinal Bleeding: A National Perspective. Digestive Diseases and Sciences 2020; 66(3): 751-9;","DOI":"10.1007\/s10620-020-06315-1"},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"Zhang J, Chi H, Xiao H, Tian X , Wang Y, Yun X , et al. Interleukin 6 (IL-6) and Tumor Necrosis Factor a (TNF-a) Single Nucleotide Polymorphisms (SNPs), Inflammation and Metabolism in Gestational Diabetes Mellitus in Inner Mongolia. Med Sci Monit 2017; 23: 4149-57;","DOI":"10.12659\/MSM.903565"},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"Desborough MJR, Oakland KA, Landoni G, Crivellari M, Doree C, Estcourt LJ, et al. Desmopressin for treatment of platelet dysfunction and reversal of antiplatelet agents: a systematic review and meta analysis of randomised controlled trials. Journal of Thrombosis and Haemostasis 2017; 15(2): 263-72;","DOI":"10.1111\/jth.13576"},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"Polak D, Talar M, Watala C, Przygodzki T Intravital Assessment of Blood Platelet Function. A Review of the Methodological Approaches with Examples of Studies of Selected Aspects of Blood Platelet Function. Int J Mol Sci 2020; 21(21): 8334;","DOI":"10.3390\/ijms21218334"},{"key":"ref30","doi-asserted-by":"crossref","unstructured":"Lee JS, Gladwin MT Bad blood: the risks of red cell storage. Nature Medicine 2010; 16(4): 381-2;","DOI":"10.1038\/nm0410-381"}],"container-title":["Journal of Medical Biochemistry"],"original-title":["Serumska superoksid dismutaza (SOD), malondialdehid (MDA), IL-6, IL-8, TNF-a, i serumskih imunolo\u0161kih markera nakon alogene transfuzije krvi kod pacijenata sa gastrointestinalnim krvarenjem"],"language":"en","link":[{"URL":"https:\/\/scindeks-clanci.ceon.rs\/data\/pdf\/1452-8258\/2026\/1452-82582602253W.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T20:44:23Z","timestamp":1772225063000},"score":1,"resource":{"primary":{"URL":"https:\/\/scindeks.ceon.rs\/Article.aspx?artid=1452-82582602253W"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.5937\/jomb0-56287","relation":{},"ISSN":["1452-8258","1452-8266"],"issn-type":[{"value":"1452-8258","type":"print"},{"value":"1452-8266","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}