{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T16:35:01Z","timestamp":1785429301823,"version":"3.56.0"},"reference-count":40,"publisher":"Centre for Evaluation in Education and Science (CEON\/CEES)","issue":"2","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/BY\/4.0"}],"funder":[{"DOI":"10.13039\/501100004564","name":"Ministry of Education, Science and Technological Development of the Republic of Serbia","doi-asserted-by":"publisher","award":["451-03-68\/2020-14\/200177"],"award-info":[{"award-number":["451-03-68\/2020-14\/200177"]}],"id":[{"id":"10.13039\/501100004564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Biochemistry"],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:p>Background: Chronic obstructive pulmonary disease (COPD) is characterised by obstruction of the small airways and includes \"flare-ups\", which are sudden and significant worsening of symptoms, sometimes caused by infections. Methods: Patients with COPD (n = 38) and acute bronchitis (AB, n=35) were grouped based on age and examined at two time points: during flare-ups\/infections and at day 30. We measured various biomarkers, including total plasma TGF-&lt;span style=\"color: rgb(32, 33, 34); font-family: sans-serif; font-size: 16px; background-color: rgb(248, 249, 250);\"&gt;\u03b2&lt;\/span&gt;1 levels, total IgA, total IgM, and Pseudomonas aeruginosa-specific IgA levels. Results: Increased TGF-&lt;span style=\"color: rgb(32, 33, 34); font-family: sans-serif; font-size: 16px; background-color: rgb(248, 249, 250);\"&gt;\u03b2&lt;\/span&gt;1 levels were detected in COPD patients in comparison to acute bronchitis patients, with no significant change observed at day 30. Paired analysis revealed a significant decrease in total plasma IgA levels in COPD patients on day 30. No significant difference in specific P aeruginosa IgA levels was observed between the two patient groups. Interestingly, a correlation between total IgM and IgA levels was absent in COPD patients, unlike in those with acute bronchitis. While a positive correlation existed between age and IgA level in patients with acute bronchitis, this correlation was negative in patients with COPD. A significant correlation was observed between total IgM and P aeruginosa-specific IgA in acute bronchitis patients. On the other hand, COPD patients showed no correlation between total IgA or IgM and P aeruginosa-specific IgA levels at different time points. Conclusions: We report on the deregulated IgA-IgM axis in COPD and call for thorough, larger-scale studies of the humoral immune system in this pathology.<\/jats:p>","DOI":"10.5937\/jomb0-57461","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T08:19:32Z","timestamp":1764145172000},"page":"265-273","source":"Crossref","is-referenced-by-count":0,"title":["Increased total plasma TGF-\u03b21 levels and deregulated IgA-IgM axis in chronic obstructive pulmonary disease"],"prefix":"10.5937","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2941-9246","authenticated-orcid":false,"given":"Rajna","family":"Mini\u0107","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0150fxq66","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivera","family":"\u0110uki\u0107","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02qsmb048","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6677-5237","authenticated-orcid":false,"given":"Dejana","family":"Kosanovi\u0107","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02qsmb048","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dejan","family":"\u017dujovi\u0107","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02122at02","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0395-4523","authenticated-orcid":false,"given":"Aleksandra","family":"Ili\u0107","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02qsmb048","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marko","family":"Pani\u0107","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0150fxq66","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4582-0809","authenticated-orcid":false,"given":"Bri\u017eita","family":"\u0110or\u0111evi\u0107","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02qsmb048","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3964","reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Orozco RJ, Rodriguez D, Hunter K, Roy S. 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