{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T13:17:05Z","timestamp":1767705425109,"version":"3.48.0"},"reference-count":32,"publisher":"Centre for Evaluation in Education and Science (CEON\/CEES)","issue":"9","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/BY\/4.0"}],"funder":[{"name":"State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Xinjiang Medical University"},{"name":"Xinjiang Medical University Student Innovation and Entrepreneurship Training Program"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Biochemistry"],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:p>Background: To observe the changes in bile acid synthase activity, conjugation enzyme gene and intestinal mucosal barrier function (D-LA, Zonulin, MFG-E8) in patients with type 2 diabetes mellitus (T2DM) after bariatric and metabolic surgery (BMS), and to provide an objective opinion on the clinical optimisation of BMS. Methods: 127 patients with T2DM who had received BMS treatment at our hospital from October 2023 to August 2024 were included in the study, and weight loss glucose-lipid metabolism was detected before surgery and 6 months after surgery. Furthermore, the study quantified the expression levels of key enzymes involved in bile acid synthesis and conjugation (CYP7A1, CYP27A1, FXR, FGF19) and markers indicative of intestinal mucosal barrier function (D-LA, Zonulin, MFG-E8). Results: After BMS, the patient's weight was significantly reduced, and glucolipid metabolism was significantly improved (P&amp;lt; 0.05). In addition, CYP7A1 was decreased, and FXR and FGF19 were elevated in patients after surgery (P &amp;lt; 0.05). Regarding the intestinal mucosal barrier function, D-LA and Zonulin were reduced in patients after surgery (P&amp;lt; 0.05). MFG-E8 was not significantly altered. Conclusions: BMS can effectively improve glucose-lipid metabolism and reduce body weight in T2DM patients, and its mechanism is related to regulating bile acid metabolism and promoting the recovery of intestinal barrier function.<\/jats:p>","DOI":"10.5937\/jomb0-58245","type":"journal-article","created":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T03:09:46Z","timestamp":1749006586000},"page":"1984-1991","source":"Crossref","is-referenced-by-count":0,"title":["Bariatric and metabolic surgery improves glycolipid metabolism via bile acid regulation and intestinal barrier repair in T2DM patients"],"prefix":"10.5937","volume":"44","author":[{"given":"Jingjing","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Department of Nephrology, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shadike","family":"Apaer","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Department of Liver Transplantation & Laparoscopic Surgery, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuo","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Department of Liver Transplantation & Laparoscopic Surgery, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guanyou","family":"Liang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Department of Liver Transplantation & Laparoscopic Surgery, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Department of Liver Transplantation & Laparoscopic Surgery, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinling","family":"Cao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Department of Liver Transplantation & Laparoscopic Surgery, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3964","reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Harreiter J, Roden M. Diabetes mellitus: definition, classification, diagnosis, screening and prevention (Update 2023). Wien Klin Wochenschr 2023; 135(Suppl 1): 7-17;","DOI":"10.1007\/s00508-022-02122-y"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Cloete L. Diabetes mellitus: an overview of the types, symptoms, complications and management. Nurs Stand 2022; 37(1): 61-6;","DOI":"10.7748\/ns.2021.e11709"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Yan Y, Wu T, Zhang M, Li C, Liu Q, Li F Prevalence, awareness and control of type 2 diabetes mellitus and risk factors in Chinese elderly population. BMC Public Health 2022; 22(1): 1382;","DOI":"10.1186\/s12889-022-13759-9"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Strati M, Moustaki M, Psaltopoulou T, Vryonidou A, Paschou SA. Early onset type 2 diabetes mellitus: an update. Endocrine 2024; 85(3): 965-78;","DOI":"10.1007\/s12020-024-03772-w"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Chen B, Bai Y, Tong F, Yan J, Zhang R, Zhong Y, et al. Glycoursodeoxycholic acid regulates bile acids level and alters gut microbiota and glycolipid metabolism to attenuate diabetes. Gut Microbes 2023; 15(1): 2192155;","DOI":"10.1080\/19490976.2023.2192155"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Castellanos-Jankiewicz A, Guzman-Quevedo O, Fenelon VS, Zizzari P Quarta C, Bellocchio L, et al. Hypothalamic bile acid-TGR5 signaling protects from obesity. Cell Metab 2021; 33(7): 1483-92 e10;","DOI":"10.1016\/j.cmet.2021.04.009"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Qi Y Duan G, Wei D, Zhao C, Ma Y. The Bile Acid Membrane Receptor TGR5 in Cancer: Friend or Foe? Molecules 2022; 27(16);","DOI":"10.3390\/molecules27165292"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Yang Y, Yu S, Rong H, Lei Z, Yang C, Wu H, et al. Sodium sulphate ameliorates hypercholesterolemia via the upregulation of Cyp7a1 in hepatocytes and alleviates hepatic insulin resistance via the downregulation of Trib3 in mice with high cholesterol diets. Exp Ther Med 2024; 28(3): 361;","DOI":"10.3892\/etm.2024.12650"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Chen Q, Cheng W, Zhang J, Chi C, Lin M, He C, et al. Fibroblast growth factor 21 improves insulin sensitivity by modulating the bile acid-gut microbiota axis in type diabetic mice. Free Radic Biol Med 2024; 224: 600-17;","DOI":"10.1016\/j.freeradbiomed.2024.09.017"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Su M, Tang T, Tang W, Long Y, Wang L, Liu M. Astragalus improves intestinal barrier function and immunity by acting on intestinal microbiota to treat T2DM: a research review. Front Immunol 2023; 14: 1243834;","DOI":"10.3389\/fimmu.2023.1243834"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Yuan JH, Xie QS, Chen GC, Huang CL, Yu T, Chen QK, et al. Impaired intestinal barrier function in type 2 diabetic patients measured by serum LPS, Zonulin, and IFABP J Diabetes Complications 2021; 35(2): 107766;","DOI":"10.1016\/j.jdiacomp.2020.107766"},{"key":"ref12","unstructured":"Zou JJ, Li H, Zhou M, Huang QQ, Wu YJ, Yu R. Zuogui Jiangtang Qinggan Prescription promotes recovery of intestinal mucosal barrier in mice with type 2 diabetes mellitus and nonalcoholic fatty liver disease by improving intestinal flora homeostasis. Zhongguo Zhong Yao Za Zhi 2023; 48(2): 525-33;"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Sun L, Yuan H, Ma H, Wang Y Effects of Cordyceps cicadae Polysaccharide on Gut Microbiota, the Intestinal Mucosal Barrier, and Inflammation in Diabetic Mice. Metabolites 2025; 15(1);","DOI":"10.3390\/metabo15010008"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Akalestou E, Miras AD, Rutter GA, le Roux CW. Mechanisms of Weight Loss After Obesity Surgery. Endocr Rev 2022; 43(1): 19-34;","DOI":"10.1210\/endrev\/bnab022"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Hedberg S, Thorell A, Osterberg J, Peltonen M, Andersson E, Naslund E, et al. Comparison of Sleeve Gastrectomy vs Roux-en-Y Gastric Bypass: A Randomised Clinical Trial. JAMA Netw Open 2024; 7(1): e2353141;","DOI":"10.1001\/jamanetworkopen.2023.53141"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Liang H, Li C. Bariatric and Metabolic Surgery and Medical Insurance Payment in China. Curr Obes Rep 2023; 12(3): 365-70;","DOI":"10.1007\/s13679-023-00507-2"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Ding L, Yang Q, Zhang E, Wang Y, Sun S, Yang Y, et al. Notoginsenoside Ft1 acts as a TGR5 agonist but FXR antagonist to alleviate high fat diet-induced obesity and insulin resistance in mice. Acta Pharm Sin B 2021; 11(6): 1541-54;","DOI":"10.1016\/j.apsb.2021.03.038"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Li C, Chen T, Liu J, Wang Y Zhang C, Guo L, et al. FGF19-Induced Inflammatory CAF Promoted Neutrophil Extracellular Trap Formation in the Liver Metastasis of Colorectal Cancer. Adv Sci (Weinh) 2023; 10(24): e2302613;","DOI":"10.1002\/advs.202302613"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Xu H, Fang F Wu K, Song J, Li Y Lu X, et al. 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Medicine (Baltimore) 2023; 102(44): e35788;","DOI":"10.1097\/MD.0000000000035788"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Chang Y, Wang K, Liu G, Zhao H, Chen X, Cai J, et al. Zinc glycine chelate ameliorates DSS-induced intestinal barrier dysfunction via attenuating TLR4\/NF-kappaB pathway in meat ducks. J Anim Sci Biotechnol 2024; 15(1): 5;","DOI":"10.1186\/s40104-023-00962-w"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"Yang Z, Yang JJ, Zhu PJ, Han HM, Wan X L, Yang HM, et al. Effects of betaine on growth performance, intestinal health, and immune response of goslings challenged with lipopolysaccharide. Poult Sci 2022; 101(11): 102153;","DOI":"10.1016\/j.psj.2022.102153"},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"Han B, Lv X, Liu G, Li S, Fan J, Chen L, et al. Gut microbiota-related bile acid metabolism-FXR\/TGR5 axis impacts the response to anti-alpha4beta7-integrin therapy in humanised mice with colitis. Gut Microbes 2023; 15(1): 2232143;","DOI":"10.1080\/19490976.2023.2232143"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"Geng R, Lin Y, Ji M, Chang Q, Li Z, Xu L, et al. MFG-E8 promotes tendon-bone healing by regulating macrophage efferocytosis and M2 polarisation after anterior cruciate ligament reconstruction. J Orthop Translat 2022; 34: 11-21;","DOI":"10.1016\/j.jot.2022.04.002"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Duan Y, Huang J, Sun M, Jiang Y, Wang S, Wang L, et al. Poria cocos polysaccharide improves intestinal barrier function and maintains intestinal homeostasis in mice. Int J Biol Macromol 2023; 249: 125953;","DOI":"10.1016\/j.ijbiomac.2023.125953"},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"Kong X, Yang C, Li B, Yan D, Yang Y, Cao C, et al. FXR\/Menin-mediated epigenetic regulation of E2F3 expression controls beta-cell proliferation and is increased in islets from diabetic G K rats after RYGB. Biochim Biophys Acta Mol Basis Dis 2024; 1870(5): 167136;","DOI":"10.1016\/j.bbadis.2024.167136"},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"Perez-Arana GM, Diaz-Gomez A, Camacho-Ramirez A, Ribelles-Garcia A, Almorza-Gomar D, Gracia-Romero M, et al. Dual effect of RYGB on the entero-insular axis: How GLP-1 is enhanced by surgical duodenal exclusion. Ann Anat 2023; 249: 152094;","DOI":"10.1016\/j.aanat.2023.152094"},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"Li H, Li L, Chen H, Wang R, Ma Y. The structure and properties of MFG-E8 and the In vitro assessment of its toxic effects on myoblast cells. Protein Expr Purif 2021; 178: 105720;","DOI":"10.1016\/j.pep.2020.105720"},{"key":"ref30","doi-asserted-by":"crossref","unstructured":"McCarty TR, Jirapinyo P, Thompson CC. Effect of Sleeve Gastrectomy on Ghrelin, GLP-1, PYY, and GIP Gut Hormones: A Systematic Review and Meta-analysis. Ann Surg 2020; 272(1): 72-80;","DOI":"10.1097\/SLA.0000000000003614"},{"key":"ref31","doi-asserted-by":"crossref","unstructured":"Wang L, Shi C, Yan H, Xia M, Zhu X, Sun X, et al. Acute Effects of Sleeve Gastrectomy on Glucose Variability, Glucose Metabolism, and Ghrelin Response. Obes Surg 2021; 31(9): 4005-14;","DOI":"10.1007\/s11695-021-05534-3"},{"key":"ref32","doi-asserted-by":"crossref","unstructured":"Zhang C, Liu K, Hou J. Extending the vitamin D pathway to vitamin D(3) and CYP27A1 in periodontal ligament cells. 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