{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T15:13:19Z","timestamp":1776265999392,"version":"3.50.1"},"reference-count":36,"publisher":"Centre for Evaluation in Education and Science (CEON\/CEES)","issue":"4","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/BY\/4.0"}],"funder":[{"name":"Suzhou Medical Key Supporting Discipline Project"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Biochemistry"],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:p>Background: To investigate the role of novel cardiac biomarkers S100A12 (Calgranulin C), FSTL1 (Follistatin-like 1), and osteocalcin in patients with acute chest pain (ACP) and evaluate their modulation by optimised emergency care protocols. Methods: A cohort of 116 ACP patients was divided into a research group (RG, n = 58) receiving optimised emergency care and a control group (CG, n = 58) receiving standard care. Serum levels of traditional biomarkers (troponin I, creatine kinase-MB [CK-MB], C-reactive protein [CRP], interleukin-6 [IL-6]) and novel biomarkers (S100A12, FSTL1, osteocalcin) were measured at baseline and post-intervention. Clinical outcomes, including triage time, hospital stay, and adverse events, were assessed to correlate with biochemical changes. Results: The RG exhibited significantly lower serum levels of troponin I, CK-MB, CRP, IL-6, S100A12, and FSTL1 post-intervention compared to the CG (P&amp;lt; 0.05), indicating reduced myocardial injury and inflammation. Osteocalcin levels were higher in the RG (P&amp;lt; 0.05), suggesting improved vascular and metabolic function. Clinically, the RG showed shorter triage times, reduced hospital stays, and lower adverse event rates (P&amp;lt; 0.05). Conclusions: Optimised emergency care modulates novel biomarkers S100A12, FSTL1, and osteocalcin, alongside traditional markers, reflecting reduced cardiac stress and inflammation in ACP patients. These findings suggest a biochemical basis for improved clinical outcomes and highlight the potential of these biomarkers as diagnostic and prognostic tools in ACP management.<\/jats:p>","DOI":"10.5937\/jomb0-58940","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T09:21:30Z","timestamp":1761816090000},"page":"731-739","source":"Crossref","is-referenced-by-count":0,"title":["Novel cardiac biomarkers (serum S100A12 (Calgranulin C), FSTL1 (Follistatin-like 1), and osteocalcin) in patients with acute chest pain"],"prefix":"10.5937","volume":"45","author":[{"given":"Wenjing","family":"Xie","sequence":"first","affiliation":[{"name":"The Affiliated Suzhou Hospital of Nanjing University Medical School, Department of Emergency, Suzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhao","sequence":"additional","affiliation":[{"name":"The Affiliated Suzhou Hospital of Nanjing University Medical School, Department of Emergency, Suzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongtao","family":"Wang","sequence":"additional","affiliation":[{"name":"The Affiliated Suzhou Hospital of Nanjing University Medical School, Department of Emergency, Suzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanguang","family":"Xie","sequence":"additional","affiliation":[{"name":"The Affiliated Suzhou Hospital of Nanjing University Medical School, Department of Emergency, Suzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luyan","family":"Gu","sequence":"additional","affiliation":[{"name":"The Affiliated Suzhou Hospital of Nanjing University Medical School, Department of Emergency, Suzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3964","reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Crawshaw AA, Cock HR. Medical management of status epilepticus: Emergency room to intensive care unit. Seizure 2020; 75: 145-52;","DOI":"10.1016\/j.seizure.2019.10.006"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Malik N, Dhuldhaj UP Available drug therapies on COVID-19 and its side effects: An overview. Cell Mol Biomed Rep 2023; 3(1): 41-58;","DOI":"10.55705\/cmbr.2022.364739.1071"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Mohr NM, Wessman BT, Bassin B, Elie-Turenne MC, Ellender T Emlet LL, et al. Boarding of Critically Ill Patients in the Emergency Department. Crit Care Med 2020; 48(8):1180-7;","DOI":"10.1097\/CCM.0000000000004385"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Dawson LP Smith K, Cullen L, Nehme Z , Lefkovits J, Taylor AJ, et al. Care Models for Acute Chest Pain That Improve Outcomes and Efficiency: JACC State-of-the-Art Review. J Am Coll Cardiol 2022; 79(23): 2333-48;","DOI":"10.1016\/j.jacc.2022.03.380"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Aziziaram Z, Bilal I, Zhong Y, Mahmod AK, Roshandel MR. Protective effects of curcumin against naproxen-induced mitochondrial dysfunction in rat kidney tissue. Cell Mol Biomed Rep 2021; 1(1): 23-32;","DOI":"10.55705\/cmbr.2021.138879.1001"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Saravani K, Afshari M, Aminisefat A, Bameri O. Blood Sugar Changes in Patients with Acute Drug Poisoning. Cell Mol Biomed Rep 2021; 1(2): 91-7;","DOI":"10.55705\/cmbr.2021.146061.1022"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Sarto G, Simeone B, Spadafora L, Bernardi M, Rocco E, Pelle G, et al. Management of acute chest pain in the Emergency Department: benefits of coronary computed tomography angiography. Int J Cardiovasc Imaging 2024; 40(12): 2447-57;","DOI":"10.1007\/s10554-024-03274-w"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"M\u00f4ckel M, Stork T Acute chest pain. Internist (Berl) 2017; 58(9): 900-7;","DOI":"10.1007\/s00108-017-0299-8"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Ng IKS, Chia YW, See KC, Teo DBS. Approach to acute chest pain and acute coronary syndrome in adults. Singapore Med J 2024; 65(2): 111-8;","DOI":"10.4103\/singaporemedj.SMJ-2023-039"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Kontos MC, de Lemos JA, Deitelzweig SB, Diercks DB, Gore MO, Hess EP et al. 2022 ACC Expert Consensus Decision Pathway on the Evaluation and Disposition of Acute Chest Pain in the Emergency Department: A Report of the American College of Cardiology Solution Set Oversight Committee. J Am Coll Cardiol 2022; 80(20): 1925-60;","DOI":"10.1016\/j.jacc.2022.08.750"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Diaz-Betancur JS, Martinez JM, Zapata JG, Marin-Orozco I. Chest pain and acute coronary syndrome in octogenarians admitted to the Emergency Department. Aging Clin Exp Res 2021; 33(8): 2213-21;","DOI":"10.1007\/s40520-020-01737-3"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Mackintosh NJ, Davis RE, Easter A, Rayment-Jones H, Sevdalis N, Wilson S, et al. Interventions to increase patient and family involvement in escalation of care for acute life-threatening illness in community health and hospital settings. Cochrane Database Syst Rev 2020; 12(12): Cd012829;","DOI":"10.1002\/14651858.CD012829.pub2"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Ingram SJ, McKee G, Quirke MB, Kelly N, Moloney A. Discharge of Non-Acute Coronary Syndrome Chest Pain Patients From Emergency Care to an Advanced Nurse Practitioner-Led Chest Pain Clinic: A Cross-Sectional Study of Referral Source and Final Diagnosis. J Cardiovasc Nurs 2017; 32(2): E1-e8;","DOI":"10.1097\/JCN.0000000000000374"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Forslund K, Kihlgren M, Ostman I, Sorlie V Patients with acute chest pain - experiences of emergency calls and pre-hospital care. J Telemed Telecare 2005; 11(7): 361-7;","DOI":"10.1177\/1357633X0501100702"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Mao Y, Chen Y, Wang A. Effect of chained one-stop emergency nursing combined with optimised triage path nursing on the rescue effect of chest pain patients in emergency department. Biotechnol Genet Eng Rev 2023: 1-12;","DOI":"10.1080\/02648725.2023.2193479"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Zhang Y, Cao Y, Xin Y, Liu Y Significance of detecting cardiac troponin I and creatine kinase MB in critically Ill children without primary cardiac illness. Front Pediatr 2024; 12 :14 4565 1;","DOI":"10.3389\/fped.2024.1445651"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Wang X Y Zhang F Zhang C, Zheng LR, Yang J. The Biomarkers for Acute Myocardial Infarction and Heart Failure. Biomed Res Int 2020; 2020: 2018035;","DOI":"10.1155\/2020\/2018035"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Picod A, Morisson L, de Roquetaillade C, Sadoune M, Mebazaa A, Gayat E, et al. Systemic Inflammation Evaluated by Interleukin-6 or C-Reactive Protein in Critically Ill Patients: Results From the FROG-ICU Study. Front Immunol 2022; 13: 868348;","DOI":"10.3389\/fimmu.2022.868348"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Oesterle A, Bowman MA. S100A12 and the S100\/Calgranulins: Emerging Biomarkers for Atherosclerosis and Possibly Therapeutic Targets. Arterioscler Thromb Vasc Biol 2015; 35(12): 2496-507;","DOI":"10.1161\/ATVBAHA.115.302072"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Ponce-Ruiz N, Herrera-Moreno JF Rojas-Garcia AE, Barron-Vivanco BS, Gonzalez-Arias CA, Bernal-Hernandez Y Y et al. Follistatin-like 1 (FSTL1) levels as potential early biomarker of cardiovascular disease in a Mexican population. Heart Vessels.2024; 39(6): 563-70;","DOI":"10.1007\/s00380-024-02364-y"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"Magni P Macchi C, Sirtori CR, Corsi Romanelli MM. Osteocalcin as a potential risk biomarker for cardiovascular and metabolic diseases. Clin Chem Lab Med 2016; 54(10): 1579-87;","DOI":"10.1515\/cclm-2015-0953"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Maruyama S, Nakamura K, Papanicolaou KN, Sano S, Shimizu I, Asaumi Y et al. Follistatin-like 1 promotes cardiac fibroblast activation and protects the heart from rupture. EMBO Mol Med 2016; 8(8): 949-66;","DOI":"10.15252\/emmm.201506151"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"Sandoval Y Apple FS, Mahler SA, Body R, Collinson PO, Jaffe AS. High-Sensitivity Cardiac Troponin and the 2021 AHA\/ACC\/ASE\/CHEST\/SAEM \/SCCT\/SCMR Guidelines for the Evaluation and Diagnosis of Acute Chest Pain. Circulation 2022; 146(7): 569-81;","DOI":"10.1161\/CIRCULATIONAHA.122.059678"},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"Arora G, Bittner V. Chest pain characteristics and gender in the early diagnosis of acute myocardial infarction. Curr Cardiol Rep 2015; 17(2): 5;","DOI":"10.1007\/s11886-014-0557-5"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"Kenny JF Chang BC, Hemmert KC. Factors Affecting Emergency Department Crowding. Emerg Med Clin North Am 2020; 38(3): 573-87;","DOI":"10.1016\/j.emc.2020.04.001"},{"key":"ref26","unstructured":"von Schweinitz B, Pinkston J. Emergency department management of patients with rectal bleeding. Emerg Med Pract 2023; 25(9): 1-24;"},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"Wang F Zhang Z. Effect of seamless and coherent nursing mode before and after emergency treatment on nursing treatment of patients with acute chest pain. Minerva Med 2022; 113(5): 902-4;","DOI":"10.23736\/S0026-4806.20.06624-0"},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"Foley AL. Not Just Chest Pain: Presenting Symptoms of Acute Coronary Syndrome by Gender: A Research to Practice Summary. J Emerg Nurs 2019; 45(4): 462-4;","DOI":"10.1016\/j.jen.2019.05.004"},{"key":"ref29","unstructured":"Zhang Q, Yu Y Effects of graded emergency nursing on resuscitation outcomes, prognosis, and nursing satisfaction in patients with acute myocardial infarction. Am J Transl Res 2021; 13(9): 10586-92;"},{"key":"ref30","doi-asserted-by":"crossref","unstructured":"Li W, Cao Q. Efficacy of Graded Emergency Nursing on Acute Pancreatitis Patients: A Meta-Analysis. Iran J Public Health 2021; 50(6): 1097-107;","DOI":"10.18502\/ijph.v50i6.6409"},{"key":"ref31","doi-asserted-by":"crossref","unstructured":"Lihui L, Qing Y Optimising the Prehospital-Hospital Emergency Care Path Application Value in Emergency Treatment of Patients with Cerebral Hemorrhage. J Healthc Eng 2021; 2021: 2352208;","DOI":"10.1155\/2021\/2352208"},{"key":"ref32","doi-asserted-by":"crossref","unstructured":"Z\u00e8gre-Hemsey JK. Optimising Patient Outcomes in Emergency Cardiac Care Through Advances in Technology: Nurse Scientists in Action. J Emerg Nurs 2020; 46(2): 136-8;","DOI":"10.1016\/j.jen.2020.01.007"},{"key":"ref33","doi-asserted-by":"crossref","unstructured":"Li S, Liu K, Liu Z, Wang Y Effect of Four-in-One Optimised Emergency Nursing Procedure on Symptoms and Vital Signs of Patients with Mushroom Poisoning. J Healthc Eng 2022; 2022: 3387394;","DOI":"10.1155\/2022\/3387394"},{"key":"ref34","doi-asserted-by":"crossref","unstructured":"Lu L, Wang X, Xu Y Analysis on the application of optimising path of emergency nursing process in patients with acute myocardial infarction. Minerva Surg 2022; 77(6): 631-4;","DOI":"10.23736\/S2724-5691.21.09232-7"},{"key":"ref35","doi-asserted-by":"crossref","unstructured":"Wei F, Tan H, He Y, Shu X. Impact of Optimising the Emergency Care Process on the Emergency Effect and Prognosis of Patients with Hepatic Encephalopathy. Emerg Med Int 2022; 2022: 4446215;","DOI":"10.1155\/2022\/4446215"},{"key":"ref36","doi-asserted-by":"crossref","unstructured":"Guihong R, Xiao W, Xinling Q, Yanxia W, Meilian Q, Chunfeng X. Plasma biomarkers for predicting heart failure in patients with acute myocardial infarction. 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