{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T13:17:24Z","timestamp":1767705444046,"version":"3.48.0"},"reference-count":17,"publisher":"Centre for Evaluation in Education and Science (CEON\/CEES)","issue":"9","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/BY\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Biochemistry"],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:p>Background: Originally classified among antiepileptic drugs, pregabalin has been prescribed for clinical conditions such as neuropathic pain, generalised anxiety disorder, and fibromyalgia. In recent years, accumulating evidence has highlighted its potential for misuse and abuse, particularly among individuals with a high prevalence of opioid dependence. This study aims to conduct a comprehensive bibliometric analysis of global research on pregabalin misuse and abuse, to identify key trends, influential contributors, and collaborative networks. Methods: Bibliometric design was employed using data retrieved from the Web of Science Core Collection database. The search was conducted in February 2025, and relevant publications were identified based on predefined inclusion and exclusion criteria. A total of 449 eligible records were exported and compiled for analysis. The bibliometric analysis was carried out using the bibliometrix R package and its Web-based interface Biblioshiny, both operating within the RStudio environment. Results: The analysis revealed a notable increase in scientific output on pregabalin misuse and dependence, particularly after 2010. The United States emerged as the most prolific and central country within the global collaboration network, followed by the United Kingdom, Germany, and France. Leading authors and institutions were concentrated in specific academic clusters. Keywords such as \"abuse,\" \"addiction,\" and \"opioids\" have shown an increasing trend since 2016. Conclusions: This study highlights the growing academic interest in the misuse and abuse potential of pregabalin, particularly over the past decade. The findings reveal a centralised research structure, with significant contributions from high-capacity countries such as the United States, the United Kingdom, and Germany. Emerging participation from developing countries, including T\u00fcrkiye, underscores a broadening global awareness of the issue. The results emphasise the importance of interdisciplinary collaboration, policies, and the critical role of clinical laboratories in monitoring pregabalin-related risks.<\/jats:p>","DOI":"10.5937\/jomb0-59752","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T07:32:12Z","timestamp":1755588732000},"page":"1902-1909","source":"Crossref","is-referenced-by-count":0,"title":["Trends in pregabalin misuse and abuse: A 25-year bibliometric perspective"],"prefix":"10.5937","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7991-1645","authenticated-orcid":false,"given":"Saliha","family":"Aksun","sequence":"first","affiliation":[{"name":"Izmir Katip Celebi University, Medical Faculty, Department of Medical Biochemistry, Atat\u00fcrk Education and Research Hospital, Department of Clinical Biochemistry, Izmir, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9190-6064","authenticated-orcid":false,"suffix":"Furkan","given":"Karalar","family":"Oguz","sequence":"additional","affiliation":[{"name":"Izmir Katip Celebi University, Medical Faculty, Department of Medical Biochemistry, Atat\u00fcrk Education and Research Hospital, Department of Clinical Biochemistry, Izmir, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3055-0455","authenticated-orcid":false,"given":"Mert","family":"\u00dcge","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Karabuk Public Health Laboratory, Karabuk, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9429-238X","authenticated-orcid":false,"given":"Berna","family":"Cafer","sequence":"additional","affiliation":[{"name":"Ege University Health Sciences Institute, Izmir, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3964","reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Schifano F Misuse and abuse of pregabalin and gabapentin: cause for concern? CNS drugs 2014; 28(6): 491-6. https:\/\/doi.org\/10.1007\/s40263-014-0164-4;","DOI":"10.1007\/s40263-014-0164-4"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Evoy KE, Morrison MD, Saklad SR. Abuse and misuse of pregabalin and gabapentin. Drugs 2017; 77: 403-26. https:\/\/doi.org\/10.1007\/s40265-017-0700-x;","DOI":"10.1007\/s40265-017-0700-x"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Evoy KE, Sadrameli S, Contreras J, Covvey JR, Peckham AM, et al. Abuse and misuse of pregabalin and gabapentin: a systematic review update. Drugs 2021; 81: 125-56. https:\/\/doi.org\/10.1007\/s40265-020-01432-7;","DOI":"10.1007\/s40265-020-01432-7"},{"key":"ref4","unstructured":"Dependence WECoD. Pre-review report. Expert Committee on Drug Dependence. Forty-first meeting 2018. https:\/\/doi.org\/10.1016\/j.drugalcdep.2018.10.001;"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Al-Husseini A, Wazaify M, Van Hout MC. Pregabalin misuse and abuse in Jordan: a qualitative study of user experiences. International journal of mental health and addiction 2018; 16: 642-54. https:\/\/doi.org\/10.1007\/s11469-017-9813-4;","DOI":"10.1007\/s11469-017-9813-4"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Donthu N, Kumar S, Mukherjee D, Pandey N, Lim WM. How to conduct a bibliometric analysis: An overview and guidelines. Journal of Business Research 2021; 133: 285-96. https:\/\/doi.org\/10.1016\/j.jbusres.2021.04.070;","DOI":"10.1016\/j.jbusres.2021.04.070"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Aria M, Cuccurullo C. Bibliometrix: An R-tool for comprehensive science mapping analysis. Journal of informetrics 2017; 11(4): 959-75. https:\/\/doi.org\/10.1016\/j.joi.2017.08.007;","DOI":"10.1016\/j.joi.2017.08.007"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Freeman LC. A set of measures of centrality based on betweenness. Sociometry 1977: 35-41. https:\/\/doi.org\/10.2307\/3033543;","DOI":"10.2307\/3033543"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Rousseeuw PJ. Silhouettes: a graphical aid to the interpretation and validation of cluster analysis. Journal of computational and applied mathematics 1987; 20: 53-65. https:\/\/doi.org\/10.1016\/0377-0427(87)90125-7;","DOI":"10.1016\/0377-0427(87)90125-7"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Chiappini S, Schifano F A decade of gabapentinoid misuse: an analysis of the European Medicines Agency's 'Suspected Adverse Drug Reactions' database. CNS drugs 2016; 30: 647-54. https:\/\/doi.org\/10.1007\/s40263-016-0359-y;","DOI":"10.1007\/s40263-016-0359-y"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Kapil V, Green JL, Le Lait M-C, Wood DM, Dargan PI. Misuse of the g-aminobutyric acid analogues baclofen, gabapentin and pregabalin in the UK. British journal of clinical pharmacology 2013; 78(1): 190. https:\/\/doi.org\/10.1111\/bcp.12277;","DOI":"10.1111\/bcp.12277"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Schwan S, Sundstr\u00f6m A, Stjernberg E, Hallberg E, Hallberg P A signal for an abuse liability for pregabalin - results from the Swedish spontaneous adverse drug reaction reporting system. European journal of clinical pharmacology 2010; 66: 947-53. https:\/\/doi.org\/10.1007\/s00228-010-0853-y;","DOI":"10.1007\/s00228-010-0853-y"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Grosshans M, Lemenager T Vollmert C, Kaemmerer N, Schreiner R, Mutschler J, et al. Pregabalin abuse among opiate addicted patients. European journal of clinical pharmacology 2013; 69: 2021-5. https:\/\/doi.org\/10.1007\/s00228-013-1578-5;","DOI":"10.1007\/s00228-013-1578-5"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Hakkinen M, Vuori E, Kalso E, Gergov M, Ojanpera I. Profiles of pregabalin and gabapentin abuse by post-mortem toxicology. Forensic science international 2014; 241: 1-6. https:\/\/doi.org\/10.1016\/j.forsciint.2014.04.028;","DOI":"10.1016\/j.forsciint.2014.04.028"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Lyndon A, Audrey S, Wells C, Burnell ES, Ingle S, Hill R, et al. Risk to heroin users of polydrug use of pregabalin or gabapentin. Addiction 2017; 112(9): 1580-9. https:\/\/doi.org\/10.1111\/add.13843;","DOI":"10.1111\/add.13843"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Bilgener E, G\u00fcm\u00fc\u00a7 B. Pregabalin consumption in Turkey: was it an abuse. Farmacia 2021; 69(6): 1189-94. https:\/\/doi.org\/10.31925\/farmacia.2021.6.25;","DOI":"10.31925\/farmacia.2021.6.25"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Ozt\u00fcrk B, Bodur \u0406, Tekeli A, \u00c7aglar AA, Karacan CD, et al. 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