{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T05:48:54Z","timestamp":1769665734436,"version":"3.49.0"},"reference-count":20,"publisher":"Centre for Evaluation in Education and Science (CEON\/CEES)","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/BY\/4.0"}],"funder":[{"name":"Hainan Provincial Natural Science Foundation Youth Fund Project"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Biochemistry"],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:p>Background: The present study attempted to analyze the effect of mucosal-associated invariant T (MAIT) combined with inflammatory factors in identifying chronic rhinosinusitis (CRS) without nasal polyps (CRSsNP) and CRS with nasal polyps (CRSwNP) that provides a clinical reference. Methods: In this retrospective study, we enrolled 56 CRSsNP patients, 68 CRSwNP patients, and 64 healthy controls. Flow cytometry was used to detect the frequency of peripheral blood MAIT+ cells (MAIT+). Serum levels of hs-CRP, IL-ip, and IL-6 were measured by ELISA and automatic blood cell analyzer, and their correlations with MAIT cell alterations were analyzed. The diagnostic effect of MAIT+ combined with hs-CRP IL-ip, and IL-6 on CRS was analyzed using ROC curves. Results: Both CRSsNP and CRSwNP patients exhibited significantly reduced MAIT+ frequencies compared to controls (P&amp;lt; 0.05), with CRSwNP showing the most pronounced decrease (P &amp;lt; 0 .0 5 ). MAIT+ frequency was inversely correlated with hs-CRP IL-ip, and IL-6 in CRS patients. ROC analysis demonstrated that MAIT+ effectively discriminated CRSsNP (AU C= 0.793) and CRSwNP (AU C= 0.863) from healthy individuals (P&amp;lt; 0.01). After combined with inflammatory factors, the diagnostic effect of MAIT+ combined inflammatory factors on CRSsNP (AU C= 0.933) and CRSwNP (AU C= 0.939) was further improved. Conclusions: Detection of MAIT+ combined with inflammatory factors may provide potential biomarkers for CRS subtype identification.<\/jats:p>","DOI":"10.5937\/jomb0-59840","type":"journal-article","created":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T07:39:36Z","timestamp":1753429176000},"page":"133-140","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic value of mucosal-associated invariant T+ cells combined with inflammatory factors in differentiating chronic rhinosinusitis subtypes with or without nasal polyps"],"prefix":"10.5937","volume":"45","author":[{"given":"Yilong","family":"Wang","sequence":"first","affiliation":[{"name":"The Second Affiliated Hospital of Hainan Medical University, Department of Otolaryngology, Head & Neck Surgery, Haikou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongjun","family":"Feng","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Hainan Medical University, Department of Otolaryngology, Head & Neck Surgery, Haikou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Song","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Hainan Medical University, Department of Otolaryngology, Head & Neck Surgery, Haikou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhonglin","family":"Mou","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Hainan Medical University, Department of Otolaryngology, Head & Neck Surgery, Haikou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3964","reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Gao X , Zhang J, Li A, Ding Y, Zhao B, Wang Y The value of combined detection of specific immunoglobulin E, interleukin-6 and regulatory T cells in predicting the risk of postoperative recurrence in patients with eosinophilic chronic rhinosinusitis and nasal polyps. J Med Biochem 2024; 43(4): 537-44;","DOI":"10.5937\/jomb0-48780"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Xie X , Xuan L, Zhao Y Wang X , Zhang L. Diverse Endo-types of Chronic Rhinosinusitis and Clinical Implications. Clin Rev Allergy Immunol 2023; 65(3): 420-32;","DOI":"10.1007\/s12016-023-08976-y"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Cai S, Xu S, Lou H, Zhang L. Comparison of Different Biologics for Treating Chronic Rhinosinusitis With Nasal Polyps: A Network Analysis. J Allergy Clin Immunol Pract 2022; 10(7): 1876-86 e7;","DOI":"10.1016\/j.jaip.2022.02.034"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Li YR , Zhou K, Wilson M, Kramer A, Zhu Y Dawson N, et al. Mucosal-associated invariant T cells for cancer immunotherapy. Mol Ther 2023; 31(3): 631-46;","DOI":"10.1016\/j.ymthe.2022.11.019"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Zhang Y Bailey JT Xu E, Singh K, Lavaert M, Link VM, et al. Mucosal-associated invariant T cells restrict reactive oxidative damage and preserve meningeal barrier integrity and cognitive function. Nat Immunol 2022; 23(12): 1714-25;","DOI":"10.1038\/s41590-022-01349-1"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Bachert C, Bhattacharyya N, Desrosiers M, Khan AH. Burden of Disease in Chronic Rhinosinusitis with Nasal Polyps. J Asthma Allergy 2021; 14: 127-34;","DOI":"10.2147\/JAA.S290424"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Treiner E. Mucosal-associated invariant T cells in hema-tological malignancies: Current knowledge, pending questions. Front Immunol. 2023; 14: 1160943;","DOI":"10.3389\/fimmu.2023.1160943"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Chiba A, Tamura N, Yoshikiyo K, Murayama G, Kitagaichi M, Yamaji K, et al. Activation status of mucos-al-associated invariant T cells reflects disease activity and pathology of systemic lupus erythematosus. Arthritis Res Ther. 2017; 19(1): 58;","DOI":"10.1186\/s13075-017-1257-5"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Jiang Y, Wang X , Jiang Q, Chen H, Yang L, Wang W, et al. Restoration of IFN-gamma-Producing MAIT Cell Correlates to Beneficial Allergen Immunotherapy in Allergic Rhinitis Patients. Clin Exp Allergy 2025; 55(5): 403-12;","DOI":"10.1111\/cea.70051"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Sudiro M, Kuntara A, Waldi D. Correlation of Lund-Mackay Score on Computed Tomography Scan and Nasoendoscopic Score in Chronic Rhinosinusitis. Acta Inform Med 2023; 31(1): 53-6;","DOI":"10.5455\/aim.2023.31.53-56"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Tie K, Brook CD, Caradonna DS. Preoperative laboratory measurements as a predictor for nasal steroid irrigations after sinus surgery for chronic rhinosinusitis with nasal polyps. Am J Otolaryngol 2024; 45(4): 104359;","DOI":"10.1016\/j.amjoto.2024.104359"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Li H, Wang Y, Wang J. Th17\/Treg cells regulated by inter-leukin 6 in the pathogenesis of chronic rhinosinusitis with nasal polyps. Eur Arch Otorhinolaryngol 2022; 279(7): 3493-501;","DOI":"10.1007\/s00405-021-07163-z"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Purohit SK, Corbett AJ, Slobedman B, Abendroth A. Varicella Zoster Virus infects mucosal associated Invariant T cells. Front Immunol 2023; 14: 1121714;","DOI":"10.3389\/fimmu.2023.1121714"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Kim OS, Park KJ, Jin HM, Cho YN , Kim YS, Kwon SH, et al. Activation and increased production of interleukin-17 and tumour necrosis factor-alpha of mucosal-associated invariant T cells in patients with periodontitis. J Clin Periodontol 2022; 49(7): 706-16;","DOI":"10.1111\/jcpe.13648"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Rha MS, Yoon YH , Koh JY, Jung JH, Lee HS, Park SK, et al. IL-17A-producing sinonasal MAIT cells in patients with chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol 2022; 149(2): 599-609 e7;","DOI":"10.1016\/j.jaci.2021.07.037"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Qu J, Wu B, Chen L, Wen Z, Fang L, Zheng J, et al. CXCR6-positive circulating mucosal-associated invariant T cells can identify patients with non-small cell lung cancer responding to anti-PD-1 immunotherapy. J Exp Clin Cancer Res 2024; 43(1): 134;","DOI":"10.1186\/s13046-024-03046-3"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"van der Meer RG, Spoorenberg A, Brouwer E, Doornbos-van der Meer B, Boots AMH, Arends S, et al. Mucosal-associated invariant T cells in patients with axial spondyloarthritis. Front Immunol 2023; 14: 1128270;","DOI":"10.3389\/fimmu.2023.1128270"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Wang X, Sima Y, Zhao Y, Zhang N, Zheng M, Du K, et al. Endotypes of chronic rhinosinusitis based on inflammatory and remodeling factors. J Allergy Clin Immunol 2023; 151(2): 458-68;","DOI":"10.1016\/j.jaci.2022.10.010"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Estevez O, Anibarro L, Garet E, Martinez A, Pena A, Barcia L, et al. Multi-parameter flow cytometry immunophenotyping distinguishes different stages of tuberculosis infection. J Infect 2020; 81(1): 57-71;","DOI":"10.1016\/j.jinf.2020.03.064"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Wang H, Chen Z, McCluskey J, Corbett AJ. Mouse models illuminate MAIT cell biology. Mol Immunol 2021; 130: 55-63;","DOI":"10.1016\/j.molimm.2020.12.007"}],"container-title":["Journal of Medical Biochemistry"],"original-title":["Dijagnosti\u010dka vrednost invarijantnih t+ \u0107elija povezanih sa mukozom u kombinaciji sa inflamatornim faktorima u diferencijanju podtipova hroni\u010dnog rhinosinusitisa sa ili bez nazalnih polipa"],"language":"en","link":[{"URL":"https:\/\/scindeks-clanci.ceon.rs\/data\/pdf\/1452-8258\/2026\/1452-82582601133W.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T17:57:11Z","timestamp":1769623031000},"score":1,"resource":{"primary":{"URL":"https:\/\/scindeks.ceon.rs\/Article.aspx?artid=1452-82582601133W"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.5937\/jomb0-59840","relation":{},"ISSN":["1452-8258","1452-8266"],"issn-type":[{"value":"1452-8258","type":"print"},{"value":"1452-8266","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}