{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T06:07:59Z","timestamp":1769666879215,"version":"3.49.0"},"reference-count":20,"publisher":"Centre for Evaluation in Education and Science (CEON\/CEES)","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/BY\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Biochemistry"],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:p>Background: To investigate the impacts of musculoskeletal ultrasound (MSK-US)-guided needle-knife on serum pain mediators, stress response, inflammatory markers, and coagulation function in lumbar disc herniation (LDH) patients. Methods: In this prospective cohort study, we recruited 100 LDH patients admitted between February 2024 and January 2025 and assigned them to an MSK-US group (52 cases undergoing MSK-US-guided needle-knife) and a conventional group (48 cases receiving conventional needle-knife). Peripheral venous blood was collected before and within 2 hours postoperatively for IL-6, TNF-a, SP 5-HT, and hs-CRP measurements by ELISA, Cor, E, and NE determination using an automatic biochemical analyzer, b-EP detection by chemiluminescent immunoassay, and APTT, PT, FIB, and D-D quantification with a coagulation analyzer. Dynamic changes in these biomarkers were analyzed by betweenand within-group comparisons. Results: Both groups demonstrated postoperative reductions in SP and 5-HT and an elevation in b-EP (P&amp;lt; 0.05), though no marked inter-group differences were noted (P&amp;gt; 0.05). The MSK-US group showed lower postoperative levels of Cor, E, NE, IL-6, hs-CRP D-D, and FIB than the conventional group (P&amp;lt; 0.05), suggesting MSK-US's ability to reduce inflammation, alleviate stress reaction, and lower hyperfibrinolysis risk. Conclusions: MSK-US-guided needle-knife is effective in mitigating perioperative stress response and systemic inflammation in LDH patients while reducing the risk of coagulation disorders and providing a biomarker-driven framework for personalized postoperative management.<\/jats:p>","DOI":"10.5937\/jomb0-59930","type":"journal-article","created":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T08:54:52Z","timestamp":1754297692000},"page":"100-108","source":"Crossref","is-referenced-by-count":0,"title":["Changes in serum pain mediators, stress response, inflammatory markers, and coagulation function in lumbar disc herniation patients treated by musculoskeletal ultrasound-guided needle-knife"],"prefix":"10.5937","volume":"45","author":[{"given":"Jiaqi","family":"Wu","sequence":"first","affiliation":[{"name":"Jingjiang People's Hospital Affiliated to Yangzhou University, Department of Rehabilitation Medicine, Taizhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Chen","sequence":"additional","affiliation":[{"name":"Jingjiang People's Hospital Affiliated to Yangzhou University, Department of Rehabilitation Medicine, Taizhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenlong","family":"Liu","sequence":"additional","affiliation":[{"name":"Jingjiang People's Hospital Affiliated to Yangzhou University, Department of Ultrasound Diagnosis, Taizhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaming","family":"Jiang","sequence":"additional","affiliation":[{"name":"Jingjiang People's Hospital Affiliated to Yangzhou University, Department of Rehabilitation Medicine, Taizhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sihan","family":"Chen","sequence":"additional","affiliation":[{"name":"Jingjiang People's Hospital Affiliated to Yangzhou University, Department of Ultrasound Diagnosis, Taizhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingyu","family":"Liu","sequence":"additional","affiliation":[{"name":"Jingjiang People's Hospital Affiliated to Yangzhou University, Department of Rehabilitation Medicine, Taizhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"Liu","sequence":"additional","affiliation":[{"name":"Jingjiang People's Hospital Affiliated to Yangzhou University, Department of Ultrasound Diagnosis, Taizhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3964","reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Zhang AS, Xu A, Ansari K, Hardacker K, Anderson G, Alsoof D, et al. Lumbar Disc Herniation: Diagnosis and Management. Am J Med 2023; 136(7): 645-51;","DOI":"10.1016\/j.amjmed.2023.03.024"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Zhang X , Wang X , Gao L, Yang B, Wang Y, Niu K, et al. TNF-a Induces Methylglyoxal Accumulation in Lumbar Herniated Disc of Patients With Radicular Pain. Front Behav Neurosci 2021; 15: 760547;","DOI":"10.3389\/fnbeh.2021.760547"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Niu L, Zuo CJ, Zhang YL, Ma CX, Zhou XW, Sun SR, et al. Oxidative stress mediated decrement of spinal endomorphin-2 contributes to lumbar disc herniation sciatica in rats. Neurochem Int 2024; 177: 105764;","DOI":"10.1016\/j.neuint.2024.105764"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Cosamalon-Gan I, Cosamalon-Gan T, Mattos-Piaggio G, Villar-Suarez V, Garcia-Cosamalon J, Vega-Alvarez JA. Inflammation in the intervertebral disc herniation. 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Inflammatory markers in end-stage renal disease patients on haemodialysis. J Med Biochem 2020; 39(4): 481-7;","DOI":"10.5937\/jomb0-25120"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Adler RS. Musculoskeletal ultrasound: a technical and historical perspective. J Ultrason 2023; 23(95): e172-e87;","DOI":"10.15557\/JoU.2023.0027"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Zhu L, Huang Y Hu Y Tang Q, Zhong Y Toll-like receptor 4\/nuclear factor-kappa B pathway is involved in radicular pain by encouraging spinal microglia activation and inflammatory response in a rat model of lumbar disc herniation. Korean J Pain 2021; 34(1): 47-57;","DOI":"10.3344\/kjp.2021.34.1.47"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Xin J, Wang Y, Zheng Z, Wang S, Na S, Zhang S. Treatment of Intervertebral Disc Degeneration. 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