{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T01:29:13Z","timestamp":1773797353414,"version":"3.50.1"},"reference-count":33,"publisher":"Centre for Evaluation in Education and Science (CEON\/CEES)","issue":"3","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/BY\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Biochemistry"],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:p>Background: To analyse the value of H-FABP and OPG in determining the severity of heart function in those suffering from long-term heart failure. Methods: A total of 196 patients with persistent heart failure who were admitted to our hospital between June 2023 and October 2024 were chosen. A comparison of the three groups of chronic heart failure patients' general clinical information and H-FABP and OPG levels was performed. The associations between OPG and H-FABP and various clinical forms of chronic heart failure, heart failure severity, and measurement markers related to echocardiography were examined. To assess the diagnostic utility of NT-proBNP, H-FABP, and OPG detection alone and in combination for HFrEF and HFpEF patients. All patients were monitored for three to six months following their discharge. Results: There was a positive correlation (r=0.61) between H-FABP and the NYHA classification, LA (r=0.46), LV (r=0.51), HS-TnT (r=0.31), NT-proBNP (r=0.58), SUA (r=0.38), etc., and negatively correlated with the LVEF (r=-0.76), NT-proBNP (r=0.49), etc., and negatively correlated with the LVEF (r=-0.60) (P&amp;lt;0.05). Binary logistic regression analysis of NT-proBNP, H-FABP, and OPG levels and endpoint events revealed that NT-proBNP had a high value in predicting endpoint events. The readmission rate and mortality rate of patients with chronic heart failure increased with increasing NT-proBNP concentration. Serum H-FABP and OPG all have high diagnostic value for HFrEF. Compared with the traditional biomarker NT-proBNP, H-FABP had greater sensitivity (94.9%) and specificity (83.1%) in the diagnosis of HFrEF, whereas OPG had greater sensitivity (92.3%) and lower specificity (57.7%). H-FABP and OPG can significantly improve the sensitivity (86.44%) and specificity (89.74%) in the diagnosis of patients with HFrEF. Serum NT-proBNP, H-FABP and OPG all have high diagnostic value for HFpEF. Compared with the traditional biomarker NT-proBNP, H-FABP has greater sensitivity (91.7%) and specificity (82.0%) in the diagnosis of HFpEF, whereas OPG has greater specificity (82.0%) and lower sensitivity (58.3%). Conclusions: The combined detection of H-FABP, OPG, and NT-proBNP can be used as an essential strategy for the early detection of decreased cardiac function in heart failure patients.<\/jats:p>","DOI":"10.5937\/jomb0-60310","type":"journal-article","created":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T07:48:53Z","timestamp":1756885733000},"page":"690-698","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic value and risk correlation of serum heart-type fatty acid-binding protein (H-FABP) and osteoprotegerin (OPG) in chronic heart failure"],"prefix":"10.5937","volume":"45","author":[{"given":"Zheng","family":"Weifeng","sequence":"first","affiliation":[{"name":"Ningbo Fourth Hospital, Department of Cardiology, Ningbo, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liu","family":"Mingda","sequence":"additional","affiliation":[{"name":"West China Hospital of Sichuan University, Department of Cardiology, Chengdu City, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Sanduo","sequence":"additional","affiliation":[{"name":"West China Hospital of Sichuan University, Department of Cardiology, Chengdu City, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Wang","sequence":"additional","affiliation":[{"name":"Ganzhou People's Hospital (The Affiliated Ganzhou Hospital of Nanchang University), Department of Cardiovascular Medicine, Ganzhou City, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3964","reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Tsutsui H, Albert NM, Coats AJS, Anker SD, Bayes-Genis A, Butler J, Chioncel O, Defilippi CR, Drazner MH, Felker GM, Filippatos G, Fiuzat M, Ide T , Januzzi JL Jr, Kinugawa K, Kuwahara K, Matsue Y , Mentz RJ, Metra M, Pandey A, Rosano G, Saito Y, Sakata Y, Sato N, Seferovic PM, Teerlink J, Yamamoto K, Yoshimura M. 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