{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T15:12:30Z","timestamp":1776265950033,"version":"3.50.1"},"reference-count":28,"publisher":"Centre for Evaluation in Education and Science (CEON\/CEES)","issue":"4","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/BY\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Biochemistry"],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:p>Background: To analyse the changes in and diagnostic value of immune indicators and cytokines in patients with sepsis after percutaneous nephrolithotomy (PCNL). Methods: Clinical information was gathered from 405 patients with calculi who underwent PCNL at our facility between January 2021 and December 2024. The patients were divided into a sepsis group (12 patients) and a non-sepsis group (393 patients) based on whether sepsis occurred after the operation. The levels of CD4+\/CD 8 + cells, the neutrophil-to-lymphocyte ratio (NLR), soluble trigger receptor-1 (sTREM-1) in myeloid cells, procalcitonin (PCT), tumour necrosis factor-alpha (TNF-&lt;span style=\"color: rgb(32, 33, 34); font-family: sans-serif; font-size: 16px; background-color: rgb(248, 249, 250);\"&gt;\u03b1&lt;\/span&gt;), and interleukin-6 (IL-6) were measured in the two patient groups. The predictive value of the above indicators for sepsis was analysed via receiver operating characteristic (ROC) curves. Results: The number of patients with staghorn calculi in the sepsis group was greater than that in the nonsepsis group (P&amp;lt; 0.05). The NLR and sTREM-1 levels were greater in the sepsis group than in the nonsepsis group (all P&amp;lt; 0.05), and the CD 4+\/CD 8+ ratio was lower in the sepsis group than in the nonsepsis group (P&amp;lt; 0.05). The levels of serum IL-6, TNF-&lt;span style=\"color: rgb(32, 33, 34); font-family: sans-serif; font-size: 16px; background-color: rgb(248, 249, 250);\"&gt;\u03b1&lt;\/span&gt; and PCT in the sepsis group were greater than those in the nonsepsis group (all P&amp;lt; 0.05). The area under the curve (AUC) for the combined prediction of sepsis after PCNL by each index was 0.996, with a predictive sensitivity of 91.3% and a specificity of 98.4%. Conclusions: The NLR, sTREM-1, IL-6, TNF-&lt;span style=\"color: rgb(32, 33, 34); font-family: sans-serif; font-size: 16px; background-color: rgb(248, 249, 250);\"&gt;\u03b1&lt;\/span&gt; and PCT in patients with sepsis after PCNL increased, whereas the CD 4+\/CD 8+ ratio decreased. The combined detection of these levels is beneficial for guiding the early clinical prediction of postoperative sepsis in patients undergoing PCNL.<\/jats:p>","DOI":"10.5937\/jomb0-60616","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T09:14:06Z","timestamp":1758532446000},"page":"819-824","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic value of immune indicators and cytokines in sepsis after percutaneous nephrolithotomy (PCNL)"],"prefix":"10.5937","volume":"45","author":[{"given":"Yiheng","family":"Jin","sequence":"first","affiliation":[{"name":"Wuhan University, Tongren Hospital of Wuhan University, Department of Emergency, Wuhan City, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yamei","family":"Li","sequence":"additional","affiliation":[{"name":"The 940th Hospital of Joint Logistics Support Force of Chinese People's Liberation Army, Department of Emergency, Lanzhou City, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Peking University Shenzhen Hospital, Laboratory Department, Shenzhen City, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Han","sequence":"additional","affiliation":[{"name":"Peking University Shenzhen Hospital, Laboratory Department, Shenzhen City, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingshi","family":"Yan","sequence":"additional","affiliation":[{"name":"Air Force Medical University, Air Force 986 Hospital, Department of Emergency, Xi'an City, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3964","reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Zalavadiya G, Santhosh S, Tapnikar LA, Vaidya NR, Patel VA, Patel NV Analysing Predictive Indicators of Fever and Sepsis after Percutaneous Nephrolithotomy. 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PMID: 36250840;","DOI":"10.7754\/Clin.Lab.2022.211249"}],"container-title":["Journal of Medical Biochemistry"],"original-title":["Dijagnosti\u010dka vrednost imunskih pokazatelja i citokina kod sepse nakon perkutane nefrolitotomije (PCNL)"],"language":"en","link":[{"URL":"https:\/\/aseestant.ceon.rs\/index.php\/jomb\/article\/download\/60616\/28783","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/scindeks-clanci.ceon.rs\/data\/pdf\/1452-8258\/2026\/1452-82582604819J.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T14:17:51Z","timestamp":1776262671000},"score":1,"resource":{"primary":{"URL":"https:\/\/scindeks.ceon.rs\/Article.aspx?artid=1452-82582604819J"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.5937\/jomb0-60616","relation":{},"ISSN":["1452-8258","1452-8266"],"issn-type":[{"value":"1452-8258","type":"print"},{"value":"1452-8266","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}