{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T15:12:26Z","timestamp":1776265946730,"version":"3.50.1"},"reference-count":21,"publisher":"Centre for Evaluation in Education and Science (CEON\/CEES)","issue":"4","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/BY\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Biochemistry"],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:p>Background: By tracking fluctuations in inflammatory mediators and immunoglobulins (Igs) in bacterialversus viral-induced severe asthma (SA) cases, this research seeks to identify microbial-specific immune characteristics to guide individualized treatment. Methods: This analysis included 100 children hospitalized between March 2023 and April 2025 for severe acute SA exacerbations with confirmed single-pathogen infections (50 viral vs. 50 bacterial). Serum samples collected preand post-treatment were analyzed for inflammatory mediators (Th1\/Th2\/Th17 cytokines and TNF-a) and Ig profiles (total IgE and IgG subclasses). Comparative analysis was performed to identify intergroup differences. Results: At baseline, the viral group showed higher Th1\/Th17 co-activation responses, whereas the bacterial group had elevated Th2 cytokines\/TNF-a (P &amp;lt; 0.05). Therapeutic intervention reduced all cytokine subsets, though Th1\/Th17 co-activation suppression was more marked in the viral group (P&amp;lt; 0.05), and Th2 decay lagged in the bacterial group. Besides, viral cases had elevated IgG1\/IgG3; bacterial cases showed higher IgG2 (P&amp;lt; 0.05). After treatment, the levels of IgG1 and IgG3 in the virus group continued to increase, but IgG2 did not change. Conclusions: Viral SA infections predominantly trigger Th1\/Th17 co-activation-mediated inflammation and higher IgG1\/IgG3. In contrast, bacterial infections favor a Th2-dominant profile with IgG2 elevation, resulting in slower inflammation resolution.<\/jats:p>","DOI":"10.5937\/jomb0-60933","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T07:42:39Z","timestamp":1758094959000},"page":"833-840","source":"Crossref","is-referenced-by-count":0,"title":["Comparative study of serum inflammatory mediators and immunoglobulin levels in children with severe asthma infected by viruses versus bacteria"],"prefix":"10.5937","volume":"45","author":[{"given":"Xiaoxia","family":"Zhang","sequence":"first","affiliation":[{"name":"Luzhou People's Hospital, Department of General Pediatrics, Luzhou, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guojiang","family":"Jian","sequence":"additional","affiliation":[{"name":"Luzhou People's Hospital, Department of General Pediatrics, Luzhou, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqun","family":"Zhong","sequence":"additional","affiliation":[{"name":"Luzhou People's Hospital, Department of General Pediatrics, Luzhou, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mao","family":"Li","sequence":"additional","affiliation":[{"name":"Luzhou People's Hospital, Department of General Pediatrics, Luzhou, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shifang","family":"Wan","sequence":"additional","affiliation":[{"name":"Luzhou People's Hospital, Department of General Pediatrics, Luzhou, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan","family":"Liu","sequence":"additional","affiliation":[{"name":"Luzhou People's Hospital, Department of General Pediatrics, Luzhou, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangrui","family":"Chen","sequence":"additional","affiliation":[{"name":"Luzhou People's Hospital, Department of General Pediatrics, Luzhou, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3964","reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Qian K, Xu H, Chen Z, Zheng Y Advances in pulmonary rehabilitation for children with bronchial asthma. 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