{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T15:12:50Z","timestamp":1776265970176,"version":"3.50.1"},"reference-count":23,"publisher":"Centre for Evaluation in Education and Science (CEON\/CEES)","issue":"4","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/BY\/4.0"}],"funder":[{"name":"Xinjiang Uygur Autonomous Region Traditional Chinese Medicine Youth Science and Technology Talent Project"},{"name":"In-hospital Project of Changji Branch of the First Affiliated Hospital of Xinjiang Medical University"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Biochemistry"],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:p>Background: To evaluate the clinical value of dynamically monitoring serum histone deacetylase 3 (HDAC3) and forkhead box protein O1 (FOXO1) levels in evaluating cognitive impairment (CI) in cerebral stroke (CS) patients, to enable early identification of high-risk individuals and guide targeted interventions. Methods: This study included 120 CS patients admitted from March, 2023 to March, 2024, with their serum HDAC3 and FOXO1 levels examined upon admission (T0) and at 2 (T1) and 24 hours (T2) following treatment. Differences in biomarker levels (CI group vs. non-CI group) were analyzed, and the predictive value of HDAC3 and FOXO1 for CI was determined. In addition, patients were followed up for 1 year prognosis, and the predictive effect of HDAC3 and FOXO1 on the prognostic recurrence risk of CS was analyzed. Results: CI occurred in 46 cases. HDAC3 expression was markedly increased in CI cases versus non-CI patients at T0, T1, and T2, whereas FOXO1 differed significantly only at T1 and T2 (P&amp;lt; 0.05). HDAC3 and FOXO1 showed maximal predictive value for CI at the T2 timepoint. Similarly, the increase of HDAC3 and FOXO1 was also related to the risk of prognosis recurrence of CS patients. The sensitivity and specificity of combined detection of HDAC3 and FOXO1 in predicting the prognosis recurrence of CS patients were 84.38% and 78.41% (P&amp;lt; 0.05). Conclusions: The pattern of dynamic HDAC3 and FOXO1 changes provides a new diagnostic scheme for the development of CI and prognostic recurrence risk in CS patients.<\/jats:p>","DOI":"10.5937\/jomb0-60965","type":"journal-article","created":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T07:29:07Z","timestamp":1760340547000},"page":"767-777","source":"Crossref","is-referenced-by-count":0,"title":["Dynamic monitoring of cognitive impairment and prognostic recurrence risk in patients with stroke by serum HDAC3 and FOXO1: A potential diagnostic approach"],"prefix":"10.5937","volume":"45","author":[{"given":"Xintong","family":"Liu","sequence":"first","affiliation":[{"name":"Changji Branch of the First Affiliated Hospital of Xinjiang Medical University, Department of Pain Rehabilitation Medicine, Changji, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lulu","family":"Wang","sequence":"additional","affiliation":[{"name":"Changji Branch of the First Affiliated Hospital of Xinjiang Medical University, Department of Hypertension&Cardiac Pacing Electrophysiology Science, Changji, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Xiao","sequence":"additional","affiliation":[{"name":"Changji Branch of the First Affiliated Hospital of Xinjiang Medical University, Department of Pain Rehabilitation Medicine, Changji, Xinjiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengkun","family":"Liu","sequence":"additional","affiliation":[{"name":"Changji Branch of the First Affiliated Hospital of Xinjiang Medical University, Department of Pain Rehabilitation Medicine, Changji, Xinjiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Dou","sequence":"additional","affiliation":[{"name":"Changji Branch of the First Affiliated Hospital of Xinjiang Medical University, Department of Neurology, Changji, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3964","reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Rost NS, Brodtmann A, Pase MP van Veluw SJ, Biffi A, Duering M, et al. Post-Stroke Cognitive Impairment and Dementia. Circ Res 2022; 130(8): 1252-71;","DOI":"10.1161\/CIRCRESAHA.122.319951"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Huang YY, Chen SD, Leng X Y Kuo K, Wang Z T Cui M, et al. Post-Stroke Cognitive Impairment: Epidemiology, Risk Factors, and Management. J Alzheimers Dis 2022; 86(3): 983-99;","DOI":"10.3233\/JAD-215644"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"El Husseini N, Katzan IL, Rost NS, Blake ML, Byun E, Pendlebury ST, et al. Cognitive Impairment After Ischemic and Hemorrhagic Stroke: A Scientific Statement From the American Heart Association\/American Stroke Association. Stroke 2023; 54(6): e272-e91;","DOI":"10.1161\/STR.0000000000000430"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Kaur M, Sharma S. Molecular mechanisms of cognitive impairment associated with stroke. Metab Brain Dis 2022; 37(2): 279-87;","DOI":"10.1007\/s11011-022-00901-0"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Rosete C, Ciernia AV The Two Faces of HDAC3: Neuroinflammation in Disease and Neuroprotection in Recovery. Epigenomics 2024; 16(21-22): 1373-88;","DOI":"10.1080\/17501911.2024.2419357"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Na J, Ryu HG, Park H, Park H, Lee E, Nam Y, et al. FoxO1 Alleviates the Mitochondrial ROS Levels Induced by alpha-Synuclein Preformed Fibrils in BV-2 Microglial Cells. Inflammation 2025; 48(3): 1300-12;","DOI":"10.1007\/s10753-024-02119-x"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Li N, Liu B, Xiong R, Li G, Wang B, Geng Q. HDAC3 deficiency protects against acute lung injury by maintaining epithelial barrier integrity through preserving mitochondrial quality control. Redox Biology 2023; 63: 102746;","DOI":"10.1016\/j.redox.2023.102746"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Davis DH, Creavin ST, Yip JL, Noel-Storr AH, Brayne C, Cullum S. Montreal Cognitive Assessment for the detection of dementia. Cochrane Database Syst Rev 2021; 7(7): CD010775;","DOI":"10.1002\/14651858.CD010775.pub3"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Caso V, Turc G, Abdul-Rahim AH, Castro P Hussain S, Lal A, et al. European Stroke Organisation (ESO) Guidelines on the diagnosis and management of patent foramen ovale (PFO) after stroke. Eur Stroke J 2024; 9(4): 800-34;","DOI":"10.1177\/23969873241247978"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Alemseged F, Rocco A, Arba F, Schwabova J P Wu T, Cavicchia L, et al. Posterior National Institutes of Health Stroke Scale Improves Prognostic Accuracy in Posterior Circulation Stroke. Stroke 2022; 53(4): 1247-55;","DOI":"10.1161\/STROKEAHA.120.034019"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Xiaoni Z, Yunyun X, Rongrong M. Analyzing the serum biochemical factors that influence early neurological deterioration in ischemic Stroke patients and developing a nomogram prediction model. J Med Biochem 2025; 44(1): 119-28;","DOI":"10.5937\/jomb0-51371"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Shao Y, Hu H, Li Q, Cao C, Liu D, Han Y Link between triglyceride-glucose-body mass index and future stroke risk in middle-aged and elderly chinese: a nationwide prospective cohort study. Cardiovasc Diabetol 2024; 23(1): 81;","DOI":"10.1186\/s12933-024-02165-7"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Holmen M, Hvas AM, Arendt JFH. Hyperhomocysteinemia and Ischemic Stroke: A Potential Dose-Response Association-A Systematic Review and Meta-analysis. TH Open 2021; 5(3): e420-e37;","DOI":"10.1055\/s-0041-1735978"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Mathias K, Machado RS, Stork S, Martins CD, Dos Santos D, Lippert FW, et al. Short-chain fatty acid on blood-brain barrier and glial function in ischemic stroke. Life Sci 2024; 354: 122979;","DOI":"10.1016\/j.lfs.2024.122979"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Wang Y, Hou R, Liu Y Plasma Homocysteine (Hcy) Concentration Functions as a Predictive Biomarker of SPECT-Evaluated Post-Ischemic Hyperperfusion in Acute Ischemic Stroke. Pharmgenomics Pers Med 2023; 16: 481-9;","DOI":"10.2147\/PGPM.S400767"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Gu HP Wu XF, Gong YT, Mu-Yao W, Shi MY, Sun YM, et al. RGFP966 exerts neuroprotective effect via HDAC3\/Nrf2 pathway after surgical brain injury in rats. Heliyon 2023; 9(7): e18160;","DOI":"10.1016\/j.heliyon.2023.e18160"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Fang H, Li HF, He MH, Yang M, Zhang JR HDAC3 Downregulation Improves Cerebral Ischemic Injury via Regulation of the SDC1-Dependent JAK1\/STAT3 Signaling Pathway Through miR-19a Upregulation. Molecular Neurobiology 2021; 58(7): 3158-74;","DOI":"10.1007\/s12035-021-02325-w"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Kumar V, Kundu S, Singh A, Singh S. Understanding the Role of Histone Deacetylase and their Inhibitors in Neurodegenerative Disorders: Current Targets and Future Perspective. Curr Neuropharmacol 2022; 20(1): 158-78;","DOI":"10.2174\/1570159X19666210609160017"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Wang X, Xu L, Meng Y, Chen F Zhuang J, Wang M, et al. FOXO1-NCOA4 Axis Contributes to Cisplatin-Induced Cochlea Spiral Ganglion Neuron Ferroptosis via Ferritinophagy. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024; 11(40): e2402671;","DOI":"10.1002\/advs.202402671"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Su W, Lv M, Wang D, He Y, Han H, Zhang Y, et al. Tanshinone IIA Alleviates Traumatic Brain Injury by Reducing Ischemia Reperfusion via the miR-124-5p\/FoxO1 Axis. Mediators Inflamm 2024; 2024: 7459054;","DOI":"10.1155\/2024\/7459054"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"Maejima Y Nah J, Aryan Z, Zhai P Sung EA, Liu T, et al. Mst1-mediated phosphorylation of FoxO1 and C\/EBP-beta stimulates cell-protective mechanisms in cardiomyocytes. Nat Commun 2024; 15(1): 6279;","DOI":"10.1038\/s41467-024-50393-y"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Demyanenko SV, Dzreyan VA, Uzdensky AB. Overexpression of HDAC6, but not HDAC3 and HDAC4 in the penumbra after photothrombotic stroke in the rat cerebral cortex and the neuroprotective effects of a-phenyl tropolone, HPOB, and sodium valproate. Brain Res Bull 2020; 162: 151-65;","DOI":"10.1016\/j.brainresbull.2020.06.010"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"Babaee M, Chamani E, Ahmadi R, Bahreini E, Balouchnejadmojarad T, Nahrkhalaji AS, et al. The expression levels of miRNAs-27a and 23a in the peripheral blood mononuclear cells (PBMCs) and their correlation with FOXO1 and some inflammatory and anti-inflammatory cytokines in the patients with coronary artery disease (CAD). Life Sci 2020; 256: 117898;","DOI":"10.1016\/j.lfs.2020.117898"}],"container-title":["Journal of Medical Biochemistry"],"original-title":["Dinami\u010dko pra\u0107enje kognitivnog o\u0161te\u0107enja i prognosti\u010dkog rizika od recidiva kod pacijenata sa mo\u017edanim udarom pomo\u0107u serumskih HDAC3 i FOXO1 - potencijalni dijagnosti\u010dki pristup"],"language":"en","link":[{"URL":"https:\/\/aseestant.ceon.rs\/index.php\/jomb\/article\/download\/60965\/29010","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/scindeks-clanci.ceon.rs\/data\/pdf\/1452-8258\/2026\/1452-82582604767L.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T14:18:56Z","timestamp":1776262736000},"score":1,"resource":{"primary":{"URL":"https:\/\/scindeks.ceon.rs\/Article.aspx?artid=1452-82582604767L"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.5937\/jomb0-60965","relation":{},"ISSN":["1452-8258","1452-8266"],"issn-type":[{"value":"1452-8258","type":"print"},{"value":"1452-8266","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}