{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T06:33:54Z","timestamp":1769668434993,"version":"3.49.0"},"reference-count":11,"publisher":"Centre for Evaluation in Education and Science (CEON\/CEES)","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/BY\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Biochemistry"],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:p>Background: The temperature of irrigation fluid is a crucial yet frequently neglected factor affecting perioperative hemostasis during transurethral resection of the prostate (TURP). Although the clinical implications of hypothermia are well-documented, its biochemical effects on coagulation processes and endothelial markers are not fully elucidated. Methods: Ninety patients with benign prostatic hyperplasia undergoing TURP were randomized into three groups based on irrigation fluid temperature: hypothermia (24-26 \u00b0C), mild hypothermia (28-35 \u00b0C), and preheating (36-37 \u00b0C). Peripheral blood was collected preoperatively and 6 h postoperatively to evaluate coagulation and endothelial indices, including prothrombin time (PT), activated partial thromboplastin time (APTT), platelet count (PLT), platelet aggregation rate (Pagt), and endothelin-1 (ET-1). Results: Hypothermia significantly prolonged APTT and reduced PLT and Pagt compared with preheating (P &amp;lt; 0.05), indicating impaired intrinsic pathway activity and platelet dysfunction. PT remained unchanged across groups. ET-1 levels decreased in both hypothermia and preheating groups, with the greatest reduction in preheating, suggesting differential endothelial responses. Patients in the preheating group exhibited preserved coagulation stability and fewer adverse events (6.7%) compared with hypothermia (33.3%) and mild hypothermia (23.3%) groups (P = 0.038). Conclusions: Hypothermic irrigation significantly prolonged APTT, reduced platelet count, and impaired aggregation capacity, while preheating maintained hemostatic homeostasis.<\/jats:p>","DOI":"10.5937\/jomb0-61030","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T07:11:36Z","timestamp":1759129896000},"page":"47-53","source":"Crossref","is-referenced-by-count":0,"title":["Irrigation fluid temperature modulates coagulation and endothelial biomarkers in patients undergoing TURP"],"prefix":"10.5937","volume":"45","author":[{"given":"Min","family":"Gu","sequence":"first","affiliation":[{"name":"Suzhou Hospital of Integrated Traditional Chinese and Western Medicine, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanqiu","family":"Xu","sequence":"additional","affiliation":[{"name":"Suzhou Hospital of Integrated Traditional Chinese and Western Medicine, Department of Urothoracic Surgery, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3964","reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Zhang J, Zhang M, Tang J, Yin G, Long Z, He L, et al. Animal models of benign prostatic hyperplasia. Prostate Cancer P D 2021; 24(1): 49-57;","DOI":"10.1038\/s41391-020-00277-1"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"DeCao H, Wang J, Huang Y, LiangLiu R, JunLei H, Gao L, et al. Comparison between thulium laser resection of prostate and transurethral plasmakinetic resection of prostate or transurethral resection of prostate. Sci Rep-Uk 2015; 5(14542);","DOI":"10.1038\/srep14542"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Wang JW, Man LB. Transurethral resection of the prostate stricture management. Asian J Androl 2020; 22(2): 140-4;","DOI":"10.4103\/aja.aja_126_19"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Karami AA, Zameni H, Salehi M, Mirhashemi SM. The nano-micellar curcumin improves International Prostate Symptoms Score (IPSS) in patients with benign prostatic hyperplasia: a randomized clinical trial. World J Urol 2023; 41(9): 2465-71;","DOI":"10.1007\/s00345-023-04512-x"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"May A, Broggi E, Lorphelin H, Tabchouri N, Giretti G, Pereira H, et al. Comparison of the risk of postoperative infection between transurethral vaporesection and transurethral resection of the prostate. Laser Surg Med 2014; 46(5): 405-11;","DOI":"10.1002\/lsm.22240"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Liu Z, Li YW, Wu WR, Lu Q. Long-term Clinical Efficacy and Safety Profile of Transurethral Resection of Prostate Versus Plasmakinetic Resection of the Prostate for Benign Prostatic Hyperplasia. Urology 2017; 103: 198-203;","DOI":"10.1016\/j.urology.2017.02.006"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Uchida T, Ohori M, Iwamura M, Egawa S, Ao T, Yokoyama E, et al. Visual laser ablation of the prostate and transurethral resection of the prostate for benign prostatic hyperplasia. Int J Urol 1996; 3(1 Suppl): S55-9;","DOI":"10.1111\/j.1442-2042.1996.tb00343.x"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Li T, Xu G, Yi J, Huang Y Intraoperative Hypothermia Induces Vascular Dysfunction in the CA1 Region of Rat Hippocampus. Brain Sci 2022; 12(6): 692;","DOI":"10.3390\/brainsci12060692"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Oliveira-Neto JT, Souza JP Rodrigues D, Machado MR, Alves JV Barros PR, et al. Acute Chikungunya Infection Induces Vascular Dysfunction by Directly Disrupting Redox Signaling in Endothelial Cells. Cells-Basel 2024; 13(21): 1770;","DOI":"10.3390\/cells13211770"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Jiang L, Li X , Hu J, Tang Z. Mild Hypothermia Alleviates CLP-induced Multiple Organ Dysfunction by Mitigating Pyroptosis Through the TLR4\/NF-kappaB\/NLRP3 Signaling Pathway. Arch Med Res 2023; 54(1): 7-16;","DOI":"10.1016\/j.arcmed.2022.11.005"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Ma ZZ, Yang DD, Niu ME, Lu XM , Du YT, Chin P et al. Construction of early warning classification of risk in bladder spasm and its intervention plans guided by the rate adjustment card of continuous bladder irrigation after transurethral resection of the prostate (TURP): development and usability study. Transl Androl Urol 2024; 13(5): 802-11;","DOI":"10.21037\/tau-24-150"}],"container-title":["Journal of Medical Biochemistry"],"original-title":["Temperatura te\u010dnosti za irigaciju modulira koagulaciju i endotelne biomarkere kod pacijenata koji se podvrgavaju TURP-u"],"language":"en","link":[{"URL":"https:\/\/aseestant.ceon.rs\/index.php\/jomb\/article\/download\/61030\/28840","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/scindeks-clanci.ceon.rs\/data\/pdf\/1452-8258\/2026\/1452-82582601047G.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T17:57:46Z","timestamp":1769623066000},"score":1,"resource":{"primary":{"URL":"https:\/\/scindeks.ceon.rs\/Article.aspx?artid=1452-82582601047G"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.5937\/jomb0-61030","relation":{},"ISSN":["1452-8258","1452-8266"],"issn-type":[{"value":"1452-8258","type":"print"},{"value":"1452-8266","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}