{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T01:32:17Z","timestamp":1773797537078,"version":"3.50.1"},"reference-count":21,"publisher":"Centre for Evaluation in Education and Science (CEON\/CEES)","issue":"3","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/BY\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Biochemistry"],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:p>Background: Cariogenic pulpitis is a common pediatric oral disease in which oxidative stress and inflammatory imbalance are increasingly recognized as important pathogenic mechanisms. Biochemical markers such as malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and the serum IL-6\/TNF-&lt;span style=\"color: rgb(32, 33, 34); font-family: sans-serif; font-size: 16px; background-color: rgb(248, 249, 250);\"&gt; \u03b1&lt;\/span&gt; ratio may provide insight into disease severity and progression. Methods: A total of 64 children with cariogenic pulpitis admitted between May 2023 and October 2024 were included, along with 64 healthy children as controls. Serum MDA, SOD, GSH-Px, and IL-6\/TNF-&lt;span style=\"color: rgb(32, 33, 34); font-family: sans-serif; font-size: 16px; background-color: rgb(248, 249, 250);\"&gt; \u03b1&lt;\/span&gt; ratio were measured using standard biochemical assays (TBA colorimetry, xanthine oxidase method, NADPH-coupled assay, and ELISA). Group comparisons were performed, and correlations with disease stage and caries depth were analyzed using Pearson correlation coefficients. Results: Compared with controls, children with pulpitis had significantly higher MDA and IL-6\/TNF-&lt;span style=\"color: rgb(32, 33, 34); font-family: sans-serif; font-size: 16px; background-color: rgb(248, 249, 250);\"&gt; \u03b1&lt;\/span&gt; levels (t = 18.542 and 20.639, both P &amp;lt; 0.001) and lower SOD and GSH-Px activities (t = 8.279 and 12.449, both P &amp;lt; 0.001). Within the pulpitis group (30 early stage, 24 middle stage, 10 late stage), MDA levels were positively correlated with both caries depth and disease severity (r = 0.82, P &amp;lt; 0.05), while SOD (r = -0.78, P &amp;lt; 0.05) and GSH-Px (r = -0.75, P &amp;lt; 0.05) were negatively correlated. The IL-6\/TNF-&lt;span style=\"color: rgb(32, 33, 34); font-family: sans-serif; font-size: 16px; background-color: rgb(248, 249, 250);\"&gt; \u03b1&lt;\/span&gt; ratio was positively correlated with both stage and depth (r = 0.71, P &amp;lt; 0.05), increasing significantly with lesion depth (r = 0.56, P &amp;lt; 0.05). Conclusions: Elevated MDA and IL-6\/TNF-&lt;span style=\"color: rgb(32, 33, 34); font-family: sans-serif; font-size: 16px; background-color: rgb(248, 249, 250);\"&gt; \u03b1&lt;\/span&gt; ratio reflect greater oxidative and inflammatory burden and are associated with advanced stages of pediatric cariogenic pulpitis, whereas higher SOD and GSH-Px activities are associated with earlier disease. These biochemical indices may serve as adjunctive laboratory markers for evaluating disease progression and guiding therapeutic monitoring in pediatric pulpitis.<\/jats:p>","DOI":"10.5937\/jomb0-61223","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T07:11:36Z","timestamp":1759129896000},"page":"620-625","source":"Crossref","is-referenced-by-count":0,"title":["Serum oxidative stress biomarkers (MDA, SOD, GSH-PX) and IL-6\/TNF-\u03b1 ratio as biochemical indicators of disease progression in pediatric cariogenic pulpitis"],"prefix":"10.5937","volume":"45","author":[{"given":"Mengxing","family":"Wang","sequence":"first","affiliation":[{"name":"Capital Medical University, Capital Center for Children's Health, Department of Stomatology, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian","family":"Xia","sequence":"additional","affiliation":[{"name":"Capital Medical University, Capital Center for Children's Health, Department of Stomatology, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"Capital Medical University, Capital Center for Children's Health, Department of Stomatology, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3964","reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Wang M, Xia T, Wang Y Nd: YAG laser irradiation in the treatment of live pulp preservation in pediatric cariogenic pulpitis. 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