{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:16:06Z","timestamp":1785417366322,"version":"3.56.0"},"reference-count":26,"publisher":"Centre for Evaluation in Education and Science (CEON\/CEES)","issue":"4","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/BY\/4.0"}],"funder":[{"name":"Ministry for Scientific\/Technological Development, Higher Education and Information Society, Government of the Republic of Srpska"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Biochemistry"],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:p>Background: This pilot study aimed to assess the potential of cystatin C (Cys C) as a biomarker in non-Hodgkin lymphoma (NHL) and to explore its association with paraoxonase 1 (PON1) activity. Methods: The study included 44 patients with B-cell NHL and 44 healthy subjects. Cys C was measured using the Cobas e 801 analyser (Roche Diagnostics GmbH, Mannheim, Germany), while PON1 and TAS were measured on the ILab 300+ system (Instrumentation Laboratory, Milan, Italy). Results: The serum level of Cys C (mg\/L) was significantly higher in NHL patients compared to control subjects: 1.03 (0.88-1.24) vs 0.83 (0.78-0.90), P&amp;lt;0.001. The diagnostic performance of Cys C, as assessed by the area under the ROC curve (AUC), was 0.812 (95% CI: 0.732-0.902). The optimal cut-off value for Cys C was 0.870 mg\/L, with sensitivities and specificities of 77.1% and 75.6%, respectively. A significant negative correlation was observed between Cys C and PON1 activity (r=-0.42, P=0.010) in NHL patients. Conclusion: This study underscores the potential of Cys C as a biomarker in NHL. Notably, in the multivariable analysis, Cys C was the dominant independent predictor of NHL, with each 1 SD increase in Cys C associated with approximately 11-fold higher odds of NHL. Furthermore, the negative correlation between Cys C and PON1, identified for the first time in patients with NHL, may offer valuable insights into the molecular mechanisms underlying this malignancy.<\/jats:p>","DOI":"10.5937\/jomb0-61502","type":"journal-article","created":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T08:53:07Z","timestamp":1772614387000},"page":"889-896","source":"Crossref","is-referenced-by-count":0,"title":["Serum cystatin C as a biomarker in non-Hodgkin lymphoma and its relationship with paraoxonase 1 activity"],"prefix":"10.5937","volume":"45","author":[{"given":"Bosa","family":"Mirjani\u0107-Azari\u0107","sequence":"first","affiliation":[{"name":"University of Banja Luka, Faculty of Medicine, Department of Medical Biochemistry, Banja Luka, The Republic of Srpska, Bosnia and Herzegovina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smiljana","family":"Miji\u0107","sequence":"additional","affiliation":[{"name":"Aqualab laboratory, Banja Luka, The Republic of Srpska, Bosnia and Herzegovina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zana","family":"Radi\u0107-Savi\u0107","sequence":"additional","affiliation":[{"name":"University of Banja Luka, Faculty of Medicine, Department of Medical Biochemistry, Banja Luka, The Republic of Srpska, Bosnia and Herzegovina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sini\u0161a","family":"Stankovi\u0107","sequence":"additional","affiliation":[{"name":"University Clinical Centre of the Republic of Srpska, Department of Nuclear Medicine, Banja Luka, The Republic of Srpska, Bosnia and Herzegovina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dragana","family":"Mal\u010di\u0107-Zani\u0107","sequence":"additional","affiliation":[{"name":"University of Banja Luka, Faculty of Medicine, Banja Luka, Republic of Srpska, Bosnia and Herzegovina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Nata\u0161a","given":"Egelji\u0107","family":"Mihailovi\u0107","sequence":"additional","affiliation":[{"name":"University Clinical Centre of the Republic of Srpska, Department of Nuclear Medicine, Banja Luka, The Republic of Srpska, Bosnia and Herzegovina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0110or\u0111e","family":"Stojisavljevi\u0107","sequence":"additional","affiliation":[{"name":"University of Banja Luka, Faculty of Medicine, Banja Luka, Republic of Srpska, Bosnia and Herzegovina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bojana","family":"Iveti\u0107","sequence":"additional","affiliation":[{"name":"University Clinical Centre of the Republic of Srpska, Institute of Laboratory Diagnostics, Banja Luka, Republic of Srpska, Bosnia and Herzegovina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7004-4701","authenticated-orcid":false,"given":"Nata\u0161a","family":"Bogavac-Stanojevi\u0107","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02qsmb048","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3964","reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Mussap M, Plebani M. 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