{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T15:10:38Z","timestamp":1776265838085,"version":"3.50.1"},"reference-count":32,"publisher":"Centre for Evaluation in Education and Science (CEON\/CEES)","issue":"4","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/BY\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Biochemistry"],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:p>Background: To explore the correlations between the levels\nof serum monocyte chemoattractant protein-4 (MCP-4),\nheart-type fatty acid binding protein (FABP3), and\nchemokine ligand 9 (CXCL9) and myocardial damage in\nsevere mycoplasma pneumonia (SMPP) patients.\nMethods: A total of 158 patients with severe mycoplasma\npneumonia complicated with myocardial damage were\nincluded in the SMPP group. They were divided into a\nmyocardial damage group (n=42) and a nonmyocardial\ndamage group (n = 116) according to whether myocardial\ndamage occurred. The control group consisted of an additional 102 healthy people who were examined throughout\nthe same time period. The levels of serum MCP-4, FABP3\nand CXCL9 in the two groups were compared. The patients'\ngeneral clinical data were recorded. Multivariate logistic\nregression was used to identify risk factors for myocardial\ninjury in patients with severe mycoplasma pneumonia.\nResults: The levels of serum MCP-4, FABP3 and CXCL9 in\nthe SMPP group were significantly greater (all P&amp;lt;0.05).\nCompared with those in the nonmyocardial damage group,\nserum MCP-4, FABP3, and CXCL9 levels were considerably\nhigher (all P&amp;lt; 0.05) in the group with myocardial injury Age, sex, diabetes, smoking history, hypoxemia, jaundice,\nand chronic obstructive pulmonary disease (COPD) did not\ndiffer statistically significantly between the two groups (all\nP&amp;gt; 0.05). Compared with those in the nonmyocardial damage group, the proportions of patients with hypertension,\ncoronary heart disease, and anaemia, as well as the levels\nof serum MCP-4, FABP3, and CXC L9, in the myocardial\ndamage group were significantly higher (all P&amp;lt;0.05).\nCombined hypertension, coronary heart disease, anaemia,\nand high levels of serum MCP-4, FABP3, and CXCL9 are\nrisk factors for myocardial damage in patients with severe\nmycoplasma infection. The levels of serum MCP-4, FABP3\nand CXCL9 in patients were positively correlated with the\nincidence of myocardial damage in patients with severe\nmycoplasma infection (all P&amp;lt; 0.05).\nConclusions: The levels of serum MCP-4, FABP3 and CXCL9\nare positively correlated with myocardial damage in patients\nwith severe mycoplasma pneumonia. Moreover, combined\nhypertension, coronary heart disease, anaemia and high levels of serum MCP-4, FABP3 and CXCL9 are risk factors for\nmyocardial damage in patients with severe mycoplasma infection. These three factors can serve as biological indicators\nof myocardial damage in patients with severe mycoplasma\ninfection in clinical practice and are highly important for\nassessing patients' conditions and formulating treatment\nplans.<\/jats:p>","DOI":"10.5937\/jomb0-61605","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T08:27:23Z","timestamp":1762158443000},"page":"936-944","source":"Crossref","is-referenced-by-count":0,"title":["Correlation analysis of FABP3, MCP-4, and CXCL9 levels and myocardial damage in patients with severe pneumonia"],"prefix":"10.5937","volume":"45","author":[{"given":"Longxia","family":"Du","sequence":"first","affiliation":[{"name":"The Second Affiliated Hospital of Chengdu Medical College, Department of Pulmonary and Critical Care Medicine-Section 2, Chengdu City, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianping","family":"Wang","sequence":"additional","affiliation":[{"name":"Ezhou Central Hospital, Department of Critical Care Medicine, Ezhou City, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zongxian","family":"Wu","sequence":"additional","affiliation":[{"name":"Hunan Provincial People's Hospital, Department of Intensive Care Unit, Changsha City, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianxin","family":"Lai","sequence":"additional","affiliation":[{"name":"Hunan Provincial People's Hospital, Department of Intensive Care Unit, Changsha City, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuanchen","family":"Qian","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Xuzhou Medical University, Neurosurgical Intensive Care Unit, Xuzhou City, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3964","reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Yusuf SO, Chen R Clinical characteristics of community-acquired pneumonia in children caused by mycoplasma pneumoniae with or without myocardial damage: A single-center retrospective study. World J Clin Rediatr 2023 Jun 9; 12(3): 115-124. doi: 10.5409\/wjcp.v12.i3.115. RMID: 37342450; RMCID: RMC10278075;","DOI":"10.5409\/wjcp.v12.i3.115"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Ni T, Zhao F Rredicting myocardial damage in children with mycoplasma pneumoniae pneumonia: a retrospective case-control study. BMC Infect Dis 2025 May 22; 25(1): 733. doi: 10.1186\/s12879-025-11132-w. RMID: 40405087; RMCID: RMC12100917;","DOI":"10.1186\/s12879-025-11132-w"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"He B, Li X, Dong R, Yao H, Zhou Q, Xu C, Shang C, Zhao B, Zhou H, Yu X, Xu J. Development of machine learning-based differential diagnosis model and risk prediction model of organ damage for severe Mycoplasma pneumoniae pneumonia in children. Sci Rep 2025 Mar 19; 15(1): 9431. doi: 10.1038\/s41598-025-92089-3. RMID: 40108182; RMCID: RMC11923196;","DOI":"10.1038\/s41598-025-92089-3"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Qiu J, Ge J, Cao L. D-dimer: The risk factor of children's severe Mycoplasma pneumoniae pneumonia. Front Rediatr 2022 Apr 12; 10: 828437. doi: 10.3389\/fped.2022.828437. RMID: 35498793; RMCID: RMC9039299;","DOI":"10.3389\/fped.2022.828437"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Jiao L, Zhang G, Yuan Y, Cao L. A systematic review and meta-analysis of the correlation between cough variant asthma and mycoplasma pneumonia in children. Arch Med Sci 2021 May 9; 20(5): 1579-85. doi: 10.5114\/aoms\/130286. RMID: 39649255; RMCID: RMC11623152;","DOI":"10.5114\/aoms\/130286"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Huang W, Xu X, Zhao W, Cheng Q. Refractory Mycoplasma pneumonia in children: a systematic review and meta-analysis of laboratory features and predictors. J Immunol Res 2022 Jun 26; 2022: 9227838. doi: 10.1155\/2022\/9227838. RMID: 35795531; RMCID: RMC9251082;","DOI":"10.1155\/2022\/9227838"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Zhan XW, Deng LR, Wang ZY, Zhang J, Wang MZ, Li SJ. Correlation between Mycoplasma pneumoniae drug resistance and clinical characteristics in bronchoalveolar lavage fluid of children with refractory Mycoplasma pneumoniae pneumonia. Ital J Rediatr 2022 Nov 26; 48(1): 190. doi: 10.1186\/s13052-022-01376-6. RMID: 36435821; RMCID: RMC9701416;","DOI":"10.1186\/s13052-022-01376-6"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Xu M, Li Y, Shi Y, Liu H, Tong X, Ma L, Gao J, Du Q, Du H, Liu D, Lu X, Yan Y. Molecular epidemiology of Mycoplasma pneumoniae pneumonia in children, Wuhan, 2020-2. BMC Microbiol 2024 Jan 17; 24(1): 23. doi: 10.1186\/s12866-024-03180-0. RMID: 38229068; RMCID: RMC10792977;","DOI":"10.1186\/s12866-024-03180-0"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Li J, Luu LDW, Wang X, Cui X, Huang X, Fu J, Zhu X, Li Z, Wang Y, Tai J. Metabolomic analysis reveals potential biomarkers and the underlying pathogenesis involved in Mycoplasma pneumoniae pneumonia. Emerg Microbes Infect 2022 Dec; 11(1): 593-605. doi: 10.1080\/22221751.2022.2036582. RMID: 35094669; RMCID: RMC8865114;","DOI":"10.1080\/22221751.2022.2036582"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Wang Y, Yu X, Liu F, Tian X, Quan S, Jiao A, Yang X, Zeng X, Jiao W, Qi H, Xu F, Li Q, Liu S, Xu B, Sun L, Shen A. Respiratory microbiota imbalance in children with Mycoplasma pneumoniae pneumonia. Emerg Microbes Infect 2023 Dec; 12(1): 2202272. doi: 10.1080\/22221751.2023.2202272. RMID: 37132354; RMCID: RMC10171136;","DOI":"10.1080\/22221751.2023.2202272"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Wang C, Wen J, Yan Z, Zhou Y, Gong Z, Luo Y, Li Z, Zheng K, Zhang H, Ding N, Wang C, Zhu C, Wu Y, Lei A. Suppressing neutrophil itaconate production attenuates Mycoplasma pneumoniae pneumonia. RLoS Rathog 2024 Nov 5; 20(11): e1012614. doi: 10.1371\/journal.ppat.1012614. RMID: 39499730; RMCID: RMC11567624;","DOI":"10.1371\/journal.ppat.1012614"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Li M, Lu L, Xu H. Diagnostic value of miR-34a in Mycoplasma pneumoniae pneumonia in children and its correlation with rehabilitation effect. J Cardiothorac Surg 2024 Sep 2; 19(1): 507. doi: 10.1186\/s13019-024-02992-5. RMID: 39223566; RMCID: RMC11367975;","DOI":"10.1186\/s13019-024-02992-5"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Wu L, Zheng Y, Liu J, Luo R, Wu D, Xu R, Wu D, Li X. 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World J Clin Cases 2024 Aug 6; 12(22): 4940-6. doi: 10.12998\/wjcc.v12.i22.4940. RMID: 39109035; RMCID: RMC11238786;","DOI":"10.12998\/wjcc.v12.i22.4940"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Wu L, Zhong Y, Wu D, Xu R, Ruan X, Yan J, Liu J, Li X. Immunomodulatory factor TIM3 of cytolytic active genes affected the survival and prognosis of lung adenocarcinoma patients by multi-omics analysis. Biomedicines 2022 Sep 10; 10(9): 2248. doi: 10.3390\/biomedicines10092248. RMID: 36140350; RMCID: RMC9496572;","DOI":"10.3390\/biomedicines10092248"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Wang B, Liu J, Meng LJ, Liang J, Guan FJ, Dong C. Correlation between changes in hemorheology and the HIF-1\/ERO pathway in children with Mycoplasma pneumoniae pneumonia. Clin Hemorheol Microcirc 2025 Apr; 89(4): 348-55. doi: 10.1177\/13860291251313591. RMID: 40434092;","DOI":"10.1177\/13860291251313591"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Leng J, Yang Z, Wang W. Diagnosis and prognostic analysis of Mycoplasma pneumoniae pneumonia in children based on high-resolution computed tomography. Contrast Media Mol Imaging 2022 Apr 22; 2022: 1985531. doi: 10.1155\/2022\/1985531. RMID: 35542756; RMCID: RMC9054457;","DOI":"10.1155\/2022\/1985531"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Wu L, Liu Q, Ruan X, Luan X, Zhong Y, Liu J, Yan J, Li X. Multiple omics analysis of the role of RBM10 gene instability in immune regulation and drug sensitivity in patients with lung adenocarcinoma (LUAD). Biomedicines 2023 Jun 29; 11(7): 1861. doi: 10.3390\/biomedicines11071861. PMID: 37509501; PMCID: PMC10377220;","DOI":"10.3390\/biomedicines11071861"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Song Z, Han C, Luo G, Jia G, Wang X, Zhang B. Yinqin Qingfei granules alleviate Mycoplasma pneumoniae pneumonia by inhibiting NLRP3 inflammasome-mediated macrophage pyroptosis. Front Pharmacol 2024 Aug 27; 15: 1437475. doi: 10.3389\/fphar.2024.1437475. PMID: 39257401; PMCID: PMC11383775;","DOI":"10.3389\/fphar.2024.1437475"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"Fu S, Jia W, Li P, Cui J, Wang Y, Song C. Risk factors for pneumonia among children with coinfection of influenza A virus and Mycoplasma pneumoniae. Eur J Clin Microbiol Infect Dis 2024 Jul; 43(7): 1437-44. doi: 10.1007\/s10096-024-04854-3. PMID: 38789887;","DOI":"10.1007\/s10096-024-04854-3"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Wu L, Zheng Y, Ruan X, Wu D, Xu P, Liu J, Wu D, Li X. Long-chain noncoding ribonucleic acids affect the survival and prognosis of patients with esophageal adenocarcinoma through the autophagy pathway: construction of a prognostic model. Anticancer Drugs 2022 Jan 1; 33(1): e590-e603. doi: 10.1097\/CAD.0000000000001189. PMID: 34338240; PMCID: PMC8670349;","DOI":"10.1097\/CAD.0000000000001189"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"Wang H, Zhang Y, Zhao C, Peng Y, Song W, Xu W, Wen X, Liu J, Yang H, Shi R, Zhao S. Serum IL-17A and IL-6 in pediatric Mycoplasma pneumoniae pneumonia: implications for different endotypes. Emerg Microbes Infect 2024 Dec; 13(1): 2324078. doi: 10.1080\/22221751.2024.2324078. PMID: 38407218; PMCID: PMC10997354;","DOI":"10.1080\/22221751.2024.2324078"},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"Guo P, Mei S, Wang Y, Zheng X, Li L, Cheng Y. Molecular typing of Mycoplasma pneumoniae and its correlation with macrolide resistance in children in Henan of China. Indian J Med Microbiol 2023 Nov-Dec; 46: 100435. doi: 10.1016\/j.ijmm.2023.100435. PMID: 37945129;","DOI":"10.1016\/j.ijmmb.2023.100435"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"Bao X, Wang Q, Geng H, Yuan X. Correlation of prognostic values of IL-6 and PCT levels with the severity of pneumonia caused by Mycoplasma pneumoniae in children. Pak J Med Sci 2025 May; 41(5): 1305-10. doi: 10.12669\/pjms.41.5.10448. PMID: 40469159; PMCID: PMC12130963;","DOI":"10.12669\/pjms.41.5.10448"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Wu L, Zhong Y, Yu X, Wu D, Xu P, Lv L, Ruan X, Liu Q, Feng Y, Liu J, Li X. Selective polyadenylation predicts the efficacy of immunotherapy in patients with lung adenocarcinoma by multiple omics research. Anticancer Drugs 2022 Oct 1; 33(9): 943-59. doi: 10.1097\/CAD.0000000000001319. PMID: 35946526; PMCID: PMC9481295;","DOI":"10.1097\/CAD.0000000000001319"},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"Xue J, Fan Y, Luo R, Duan Y, Ai T, Wang L. Changes in airway resistance and its correlation with disease severity in children with Mycoplasma pneumoniae pneumonia. Transl Pediatr 2025 May 30; 14(5): 939-46. doi: 10.21037\/tp-2025-103. PMID: 40519744; PMCID: PMC12163775;","DOI":"10.21037\/tp-2025-103"},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"Wei D, Zhao Y, Zhang T, Xu Y, Guo W. The role of LDH and ferritin levels as biomarkers for corticosteroid dosage in children with refractory Mycoplasma pneumoniae pneumonia. Respir Res 2024 Jul 4; 25(1): 266. doi: 10.1186\/s12931-024-02892-1. PMID: 38965565; PMCID: PMC11225272;","DOI":"10.1186\/s12931-024-02892-1"},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"Wang J, Guo C, Yang L, Sun P, Jing X. Peripheral blood microR-146a and microR-29c expression in children with Mycoplasma pneumoniae pneumonia and its clinical value. Ital J Pediatr 2023 Sep 13; 49(1): 119. doi: 10.1186\/s13052-023-01500-0. PMID: 37705091; PMCID: PMC10500935;","DOI":"10.1186\/s13052-023-01500-0"},{"key":"ref30","doi-asserted-by":"crossref","unstructured":"Wu L, Li H, Liu Y, Fan Z, Xu J, Li N, Qian X, Lin Z, Li X, Yan J. Research progress of 3D-bioprinted functional pancreas and in vitro tumor models. Int J Bioprinting 2024; 10(1): 1256. doi: 10.36922\/ijb.1256;","DOI":"10.36922\/ijb.1256"},{"key":"ref31","doi-asserted-by":"crossref","unstructured":"Pavone S, Crotti S, D'Avino N, Gobbi P, Scoccia E, Pesca C, Gobbi M, Cambiotti V, Lepri E, Cruciani D. The role of Mycoplasma ovipneumoniae and Mycoplasma arginini in the respiratory mycoplasmosis of sheep and goats in Italy: correlation of molecular data with histopathological features. Res Vet Sci 2023 Oct; 163: 104983. doi: 10.1016\/j.rvsc.2023.104983. PMID: 37639802;","DOI":"10.1016\/j.rvsc.2023.104983"},{"key":"ref32","doi-asserted-by":"crossref","unstructured":"Li YT, Zhang J, Wang MZ, Ma YM, Zhi K, Dai FL, Li SJ. Changes in coagulation markers in children with Mycoplasma pneumoniae pneumonia and their predictive value for Mycoplasma severity. Ital J Pediatr 2023 Oct 20; 49(1): 143. doi: 10.1186\/s13052-023-01545-1. PMID: 37858230; PMCID: PMC10588045;","DOI":"10.1186\/s13052-023-01545-1"}],"container-title":["Journal of Medical Biochemistry"],"original-title":["Analiza korelacije nivoa FABP3, MCP-4 i CXCL9 sa o\u0161te\u0107enjem miokarda kod pacijenata sa te\u0161kom pneumonijom"],"language":"en","link":[{"URL":"https:\/\/aseestant.ceon.rs\/index.php\/jomb\/article\/download\/61605\/29255","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/scindeks-clanci.ceon.rs\/data\/pdf\/1452-8258\/2026\/1452-82582604936D.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T14:14:44Z","timestamp":1776262484000},"score":1,"resource":{"primary":{"URL":"https:\/\/scindeks.ceon.rs\/Article.aspx?artid=1452-82582604936D"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.5937\/jomb0-61605","relation":{},"ISSN":["1452-8258","1452-8266"],"issn-type":[{"value":"1452-8258","type":"print"},{"value":"1452-8266","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}