{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T01:32:32Z","timestamp":1773797552205,"version":"3.50.1"},"reference-count":27,"publisher":"Centre for Evaluation in Education and Science (CEON\/CEES)","issue":"3","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/BY\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Biochemistry"],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:p>Background: Peripherally inserted central catheter (PICC)associated phlebitis is a common complication in leukemia treatment, closely related to inflammatory responses. Current standard management, primarily relying on catheter removal and anti-inflammatory drugs, often demonstrates insufficient efficacy in rapidly controlling inflammation, resolving symptoms, and preventing recurrence. Moreover, there is a notable lack of objective, biomarker-driven monitoring methods to guide and evaluate therapy. This study aimed to investigate the biochemical changes in key inflammatory markers - C-reactive protein (CRP), procalcitonin (PCT), erythrocyte sedimentation rate (ESR), and interleukin-6 (IL-6) - in patients with PICC-associated phlebitis, and to evaluate their value in monitoring the efficacy of basic fibroblast growth factor (bFGF) combined with light therapy, a novel approach proposed to address these limitations. Methods: A retrospective cohort of 65 leukemia patients with PICC-associated phlebitis was analyzed. Patients were divided into an intervention group (bFGF + light therapy, n=33) and a control group (standard care, n=32). Inflammatory markers (CRP, PCT, ESR, IL-6) were measured before and after 7 days of treatment using standardized laboratory assays. Phlebitis grading, visual analogue scale (VAS) pain scores, and EORTC QLQ-C30 quality of life scores were also assessed. Results: By day 7, the intervention group showed significantly greater reductions in CRP (69.9% vs 28.2%), PCT (71.2% vs 4.4%), ESR (69.7% vs 18.9%), and IL-6 (81.1% vs 14.5%) compared with controls (all P&amp;lt;0.001). These biochemical improvements paralleled reductions in phlebitis severity and pain, and correlated with enhanced quality of life scores. Conclusions: CRP, PCT, ESR, and IL-6 serve as sensitive biochemical indicators for evaluating treatment response in PICC-associated phlebitis. The findings highlight the clinical utility of these laboratory markers in monitoring therapeutic efficacy and suggest that bFGF combined with light therapy exerts significant anti-inflammatory effects in leukemia patients, offering a promising alternative to conventional strategies.<\/jats:p>","DOI":"10.5937\/jomb0-61776","type":"journal-article","created":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T08:45:01Z","timestamp":1763455501000},"page":"493-506","source":"Crossref","is-referenced-by-count":0,"title":["Biochemical indicators of inflammatory response in leukemia patients with picc-associated phlebitis: Evaluation of basic fibroblast growth factor combined with light therapy"],"prefix":"10.5937","volume":"45","author":[{"given":"Shurong","family":"Zhang","sequence":"first","affiliation":[{"name":"The Affiliated Huai'an Hospital of Xuzhou Medical University, Department of Hematology, Huai'an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaotian","family":"Yang","sequence":"additional","affiliation":[{"name":"The Affiliated Huai'an Hospital of Xuzhou Medical University, Department of Hematology, Huai'an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingxia","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Affiliated Huai'an Hospital of Xuzhou Medical University, Department of Hematology, Huai'an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Wan","sequence":"additional","affiliation":[{"name":"The Affiliated Huai'an Hospital of Xuzhou Medical University, Department of Hematology, Huai'an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youhuan","family":"Yu","sequence":"additional","affiliation":[{"name":"The Affiliated Huai'an Hospital of Xuzhou Medical University, Department of Hematology, Huai'an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3964","reference":[{"key":"ref1","unstructured":"Agarwal A, Montanarella MJ, Moon B. 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