{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T14:18:02Z","timestamp":1781619482944,"version":"3.54.5"},"reference-count":28,"publisher":"Centre for Evaluation in Education and Science (CEON\/CEES)","issue":"6","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/BY\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Biochemistry"],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:p>Background: This study aimed to evaluate the effects of structured lifestyle optimisation, including nutritional intake and exercise training, on serum levels of Complement C3, C4, IL-10, IL1-&lt;span style=\"color: rgb(32, 33, 34); font-family: sans-serif; font-size: 16px; background-color: rgb(248, 249, 250);\"&gt;\u03b2&lt;\/span&gt;, IL-6, and TNF-&lt;span style=\"color: rgb(32, 33, 34); font-family: sans-serif; font-size: 16px; background-color: rgb(248, 249, 250);\"&gt;\u03b1&lt;\/span&gt; in patients with systemic lupus erythematosus (SLE) and Libman-Sacks endocarditis (LSE). Methods: A total of 122 SLE patients with LSE, treated at our hospital from May 2022 to May 2024, were randomised into a control group (CG, n = 61) receiving conventional medical interventions and an intervention group (IG, n = 61) receiving additional personalised exercise and nutritional interventions for 24 weeks. Serum levels of Complement C3, C4, IL-10, IL1-&lt;span style=\"color: rgb(32, 33, 34); font-family: sans-serif; font-size: 16px; background-color: rgb(248, 249, 250);\"&gt;\u03b2&lt;\/span&gt;, IL-6, and TNF-&lt;span style=\"color: rgb(32, 33, 34); font-family: sans-serif; font-size: 16px; background-color: rgb(248, 249, 250);\"&gt;\u03b1&lt;\/span&gt; were measured at baseline, 3 months, and 6 months. Secondary endpoints included nutritional status (as measured by albumin and haemoglobin levels) and patient compliance. Results: Of 113 patients completing the study, the intervention group (IG) showed significant improvement in serum Complement C3 (0.84 \u00b1 0.18 g\/L vs. 0.75\u00b1 0.16 g\/L in the control group [CG], P= 0.006) and albumin levels (37.12\u00b1 5.37 g\/L vs. 35.00 \u00b1 4.89 g\/L, P= 0.03) at 6 months. Complement C4 levels increased in the IG (0.20 \u00b1 0.09 g\/L vs. 0.17\u00b1 0.12 g\/L, P= 0.136, not significant). IL-1&lt;span style=\"color: rgb(32, 33, 34); font-family: sans-serif; font-size: 16px; background-color: rgb(248, 249, 250);\"&gt;\u03b2&lt;\/span&gt; (3 .9 \u00b1 3 .7 7 pg\/mL vs. 4.6\u00b1 4.1 pg\/mL, P= 0.468) and TNF-&lt;span style=\"color: rgb(32, 33, 34); font-family: sans-serif; font-size: 16px; background-color: rgb(248, 249, 250);\"&gt;\u03b1&lt;\/span&gt; (12.6\u00b1 4.1 pg\/mL vs. 14.1 \u00b15.2 pg\/mL, P= 0.092) showed non-significant reductions in the IG compared to the CG. No significant changes were observed in IL-10 or IL-6 levels. Compliance was significantly higher in the IG (92.86% vs. 78.95% , P= 0.038). Conclusions: Structured lifestyle optimisation significantly\nimproved serum Complement C3 and albumin levels and\nshowed non-significant trends toward reductions in IL-1&lt;span style=\"color: rgb(32, 33, 34); font-family: sans-serif; font-size: 16px; background-color: rgb(248, 249, 250);\"&gt;\u03b2&lt;\/span&gt; and TNF-&lt;span style=\"color: rgb(32, 33, 34); font-family: sans-serif; font-size: 16px; background-color: rgb(248, 249, 250);\"&gt;\u03b1&lt;\/span&gt; in SLE patients with LSE, suggesting a potential\nadjunctive role in managing immune and nutritional status.<\/jats:p>","DOI":"10.5937\/jomb0-62357","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T09:00:12Z","timestamp":1764838812000},"page":"1383-1395","source":"Crossref","is-referenced-by-count":0,"title":["Effect Of treatment on serum C3, C4, IL-10, IL1-\u03b2, IL-6, TNF-\u03b1 in patients with systemic lupus erythematosus"],"prefix":"10.5937","volume":"45","author":[{"given":"Nadira","family":"Reyimu","sequence":"first","affiliation":[{"name":"The Second Affiliated Hospital of Xinjiang Medical University, Department of of Cardiovascular, Urumqi, Xinjiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueyue","family":"Jing","sequence":"additional","affiliation":[{"name":"Yan'an People's Hospital, Department of Cardiovascular Medicine, Yan'an, Shaanxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3964","reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Kiriakidou M, Ching CL. 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Acta Clin Belg 2023; 78(4): 342-57;","DOI":"10.1080\/17843286.2022.2163751"}],"container-title":["Journal of Medical Biochemistry"],"original-title":["Efekat terapije na serumske nivoe C3, C4, IL-10, IL1-\u03b2, IL-6, TNF-\u03b1 kod pacijenata sa sistemskim eritemskim lupusom"],"language":"en","link":[{"URL":"https:\/\/scindeks-clanci.ceon.rs\/data\/pdf\/1452-8258\/2026\/1452-82582606383R.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T13:44:44Z","timestamp":1781617484000},"score":1,"resource":{"primary":{"URL":"https:\/\/scindeks.ceon.rs\/Article.aspx?artid=1452-82582606383R"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.5937\/jomb0-62357","relation":{},"ISSN":["1452-8258","1452-8266"],"issn-type":[{"value":"1452-8258","type":"print"},{"value":"1452-8266","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}