{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T21:13:58Z","timestamp":1772226838751,"version":"3.50.1"},"reference-count":8,"publisher":"Centre for Evaluation in Education and Science (CEON\/CEES)","issue":"2","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/BY\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Biochemistry"],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:p>Background: Reliable haematology results are crucial for patient diagnosis and monitoring. Maintaining low variability is particularly important for key parameters such as haemoglobin, white blood cells, and platelets, especially in automated laboratory workflows where multiple haematological analysers are connected in the same line. Methods: Two residual whole blood samples, one normal and one pathological, were analysed in ten consecutive replicates on a Sysmex XN-10 analyser (XN-1) and then on a second connected analyser (XN-2). Intra-analyser and inter-analyser imprecision were calculated as coefficients of variation (CV%). Results: Intra-analyser CVs for the normal sample ranged from 0.3% for haemoglobin to 1.5% white blood cells, while inter-analyser CVs remained below 2%. For the pathological sample, intra-analyser CVs ranged from 0.3% to 1.0%, and inter-analyser CVs reached 2.1% for hematocrit and platelets. Red blood cell count, mean corpuscular volume, and neutrophils showed CVs &amp;lt;1.9%. Higher variability was observed for low-abundance populations such as eosinophils and basophils (up to 20%). Conclusions: Sysmex XN-10 analysers exhibit strong intraand inter-analyser precision for most routine haematology tests, supporting their routine use in automated haematological lines.<\/jats:p>","DOI":"10.5937\/jomb0-62919","type":"journal-article","created":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T08:32:41Z","timestamp":1766737961000},"page":"261-264","source":"Crossref","is-referenced-by-count":0,"title":["Assessing intra- and inter-analyser imprecision in automated hematological laboratories"],"prefix":"10.5937","volume":"45","author":[{"given":"Giuseppe","family":"Lippi","sequence":"first","affiliation":[{"name":"University of Verona, Section of Clinical Biochemistry, Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Tosi","sequence":"additional","affiliation":[{"name":"University of Verona, Section of Clinical Biochemistry, Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariateresa","family":"Rizza","sequence":"additional","affiliation":[{"name":"University of Verona, Section of Clinical Biochemistry, Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0487-9051","authenticated-orcid":false,"suffix":"Luca","given":"Gian","family":"Salvagno","sequence":"additional","affiliation":[{"name":"University of Verona, Section of Clinical Biochemistry, Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Pighi","sequence":"additional","affiliation":[{"name":"University of Verona, Section of Clinical Biochemistry, Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3964","reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Hoffmann JJML, Urrechaga E. Recent advances in laboratory hematology reflected by a decade of CCLM publications. Clin Chem Lab Med 2022; 61: 829-840;","DOI":"10.1515\/cclm-2022-0962"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Vis JY, Huisman A. Verification and quality control of routine hematology analyzers. Int J Lab Hematol 2016; 38 Suppl 1: 100-9;","DOI":"10.1111\/ijlh.12503"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Chhabra G. Automated hematology analyzers: Recent trends and applications. J Lab Physicians 2018; 10: 15-6;","DOI":"10.4103\/JLP.JLP_124_17"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Vidali M, Carobene A, Apassiti Esposito S, Napolitano G, Caracciolo A, et al. Standardization and harmonization in hematology: Instrument alignment, quality control materials, and commutability issue. Int J Lab Hematol 2021; 43: 364-71;","DOI":"10.1111\/ijlh.13379"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Seo JY, Lee ST, Kim SH. Performance evaluation of the new hematology analyzer Sysmex XN-series. Int J Lab Hematol 2015; 37: 155-64;","DOI":"10.1111\/ijlh.12254"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"P\u00e9rez I, Redin ME, Vives A, Garrido A, Urrechaga E, Lacasta M. Local verification between the hematological analyzers Sysmex XN-series and XE-5000. Int J Lab Hematol 2016; 38: 256-64;","DOI":"10.1111\/ijlh.12478"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Birindelli S, Aloisio E, Carnevale A, Brando B, Dolci A, Panteghini M. Evaluation of long-term imprecision of automated complete blood cell count on the Sysmex XN-9000 system. Clin Chem Lab Med 2017; 55: e219-22;","DOI":"10.1515\/cclm-2016-1176"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Coussee A, Robbrecht J, Maelegheer K, Vandewal W, Florin L. Evaluating the Performance of the New Sysmex XR-Series Haematology Analyser: A Comparative Study with the Sysmex XN-Series. LabMed 2025; 2: 5;","DOI":"10.3390\/labmed2010005"}],"container-title":["Journal of Medical Biochemistry"],"original-title":["Procena intra-i inter-analizatorske nepreciznosti u automatizovanim hematolo\u0161kim laboratorijama"],"language":"en","link":[{"URL":"https:\/\/aseestant.ceon.rs\/index.php\/jomb\/article\/download\/62919\/29649","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/scindeks-clanci.ceon.rs\/data\/pdf\/1452-8258\/2026\/1452-82582602261L.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T20:44:18Z","timestamp":1772225058000},"score":1,"resource":{"primary":{"URL":"https:\/\/scindeks.ceon.rs\/Article.aspx?artid=1452-82582602261L"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":8,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.5937\/jomb0-62919","relation":{},"ISSN":["1452-8258","1452-8266"],"issn-type":[{"value":"1452-8258","type":"print"},{"value":"1452-8266","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}