{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T10:20:13Z","timestamp":1785406813681,"version":"3.56.0"},"reference-count":44,"publisher":"Centre for Evaluation in Education and Science (CEON\/CEES)","issue":"3","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/BY\/4.0"}],"funder":[{"DOI":"10.13039\/501100004564","name":"Ministry of Education, Science and Technological Development of the Republic of Serbia","doi-asserted-by":"publisher","award":["451-03-68\/2020-14\/200161"],"award-info":[{"award-number":["451-03-68\/2020-14\/200161"]}],"id":[{"id":"10.13039\/501100004564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Biochemistry"],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:p>Background: A three-year COVID-19 pandemic revealed a\nspectrum of disease severity and clinical manifestations. The\nmost intriguing part of this phenomenon lays in inter-individual variability in COVID-19 course among patients,\nwhich is attributable to patient's age, comorbidities and general health status. Focus of this follow-up study was to\nassess leukocyte telomere length change in mild-to-moderate COVID-19 patients and concomitant influence of\ninflammation, oxidative stress (OS), pulmonary involvement\nand implemented therapy on the course of the disease.\nMethods: Routine biochemical\/haematological parameters, markers of OS (prooxidants and antioxidants), vitamin\nD, IgM and IgG antibodies level and relative length of\nleukocyte telomeres (rLTL) were measured at three timepoints (at diagnosis, after 14 and 21 days from the disease\nonset) in blood samples of 31 consecutive COVID-19\npatients, with a mild (n = 16) and moderate (n = 15) form of\nthe disease, treated on an outpatient basis.\nResults: Although the patients had reduced rLTL at baseline (median: 0.592; 25th - 75th percentiles: 0.518\u00ad\n0.724), it significantly increased during the follow-up\n(median: 0.773; 25th - 75th percentiles: 0.615-0.923; P&amp;lt;0.01). The rate of telomere attrition was associated with\nthe extent of OS and pulmonary involvement. During follow-up, the burden of OS was reduced, while antioxidant\ndefence mechanisms were recovered. The use of antibiotics and N-acetylcysteine-propolis supplementation was\nassociated with telomere lengthening.\nConclusions: Results of this study revealed significant interaction between OS, inflammation and leukocyte telomere\nlength attrition in COVID-19. Our data suggest that rRTL\ncan be a biomarker that enables more precise therapy decision and accurate patient status estimation.<\/jats:p>","DOI":"10.5937\/jomb0-63678","type":"journal-article","created":{"date-parts":[[2025,12,25]],"date-time":"2025-12-25T09:14:17Z","timestamp":1766654057000},"page":"609-619","source":"Crossref","is-referenced-by-count":1,"title":["Leukocyte telomere dynamic change in patients with mild to moderate covid-19 during three weeks of follow-up: Relation with therapy"],"prefix":"10.5937","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6980-3069","authenticated-orcid":false,"given":"Jelena","family":"Kotur-Stevuljevi\u0107","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02qsmb048","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Marina","given":"Milenkovi\u0107","family":"Roksandi\u0107","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02122at02","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7445-0504","authenticated-orcid":false,"given":"Jelena","family":"Veki\u0107","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02qsmb048","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nemanja","family":"Dimi\u0107","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01b8wwr26","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dejan","family":"Dimi\u0107","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02122at02","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6145-3850","authenticated-orcid":false,"given":"Danica","family":"\u0106uji\u0107","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02qsmb048","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3605-3652","authenticated-orcid":false,"given":"Azra","family":"Guzonji\u0107","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02qsmb048","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8233-1636","authenticated-orcid":false,"given":"Marija","family":"Gnjatovi\u0107","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02qsmb048","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Todorovi\u0107","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02qsmb048","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7004-4701","authenticated-orcid":false,"given":"Nata\u0161a","family":"Bogavac-Stanojevi\u0107","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02qsmb048","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3964","reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Schultze JL, Aschenbrenner AC. 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