{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T14:52:33Z","timestamp":1781621553687,"version":"3.54.5"},"reference-count":20,"publisher":"Centre for Evaluation in Education and Science (CEON\/CEES)","issue":"6","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/BY\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Biochemistry"],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:p>Background: Osteoporotic fracture (OPF) remains a major cause of disability in older adults. Laboratory-available composite indices integrating coagulation, inflammation, and nutritional status may facilitate risk stratification in patients with osteoporosis. To investigate the relationship between the fibrinogen-to-albumin ratio (FAR) and systemic inflammatory indices (platelet-to-lymphocyte ratio [PLR], neutrophil-to-lymphocyte ratio [NLR], and monocyte-to-lymphocyte ratio [MLR]) in osteoporosis, and to evaluate their discriminative value for identifying concurrent osteoporotic fractures. Methods: This retrospective study included 98 patients with osteoporosis admitted between January 2024 and May 2025, categorized into a fracture group (n=39) and a non-fracture group (n = 59). FAR, PLR, NLR, and MLR were calculated from routine laboratory tests obtained within 24 h of admission. Group differences were assessed, Pearson correlation was used to examine associations between FAR and inflammatory indices, and logistic regression was performed to identify independent clinical\/imaging correlates of fracture. Receiver operating characteristic (ROC) curves were constructed to evaluate discriminative performance. Results: FAR, PLR, NLR, and MLR were significantly higher in patients with osteoporosis complicated by fracture than in those without fracture (all P&amp;lt;0.001). FAR showed positive correlations with PLR, NLR, and MLR (all P&amp;lt;0.001). In multivariable analysis, age &amp;gt;60 years, lumbar-dorsal fascial injury, and the vertebral vacuum cleft sign were independently associated with fracture occurrence (all P&amp;lt;0.05). ROC analysis demonstrated high discriminative performance for FAR, PLR, NLR, and MLR, with AUCs of 0.900, 1.000, 0.998, and 0.983, respectively. Conclusion: FAR and leukocyte\/platelet-derived inflammatory ratios were elevated in osteoporotic patients with fractures and were positively interrelated, supporting an inflammation-nutrition-coagulation laboratory phenotype in OPF. These routine laboratory indices showed strong discriminative performance for identifying concurrent osteoporotic fractures and may aid laboratory-based risk stratification in clinical practice.<\/jats:p>","DOI":"10.5937\/jomb0-64875","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T09:10:30Z","timestamp":1774343430000},"page":"1269-1275","source":"Crossref","is-referenced-by-count":0,"title":["Fibrinogen-to-albumin ratio links systemic inflammation to osteoporotic fractures and shows discriminative performance together with PLR, NLR, and MLR"],"prefix":"10.5937","volume":"45","author":[{"given":"Youxin","family":"Fu","sequence":"first","affiliation":[{"name":"Chongqing Medical University First Affiliated Hospital, Department of Orthopedics, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daigui","family":"Cao","sequence":"additional","affiliation":[{"name":"Chongqing General Hospital, Department of Orthopedics, Chongqing University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeyu","family":"Liu","sequence":"additional","affiliation":[{"name":"Chongqing Medical University First Affiliated Hospital, Department of Orthopedics, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwei","family":"Liu","sequence":"additional","affiliation":[{"name":"Chongqing General Hospital, Department of Orthopedics, Chongqing University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Guo","sequence":"additional","affiliation":[{"name":"Chongqing General Hospital, Department of Orthopedics, Chongqing University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Chongqing General Hospital, Department of Orthopedics, Chongqing University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Hao","sequence":"additional","affiliation":[{"name":"Chongqing Medical University First Affiliated Hospital, Department of Orthopedics, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3964","reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Spiegl U, Bork H, Gr\u00fcninger S, Maus U, Osterhoff G, Scheyerer MJ, et al. 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Front Endocrinol 2025; 16: 1698647;"}],"container-title":["Journal of Medical Biochemistry"],"original-title":["Odnos fibrinogena i albumina povezuje sistemsku upalu sa osteoporotskim prelomima i pokazuje diskriminativne performanse zajedno sa PLR, NLR i MLR"],"language":"en","link":[{"URL":"https:\/\/scindeks-clanci.ceon.rs\/data\/pdf\/1452-8258\/2026\/1452-82582606269F.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T13:58:43Z","timestamp":1781618323000},"score":1,"resource":{"primary":{"URL":"https:\/\/scindeks.ceon.rs\/Article.aspx?artid=1452-82582606269F"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.5937\/jomb0-64875","relation":{},"ISSN":["1452-8258","1452-8266"],"issn-type":[{"value":"1452-8258","type":"print"},{"value":"1452-8266","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}