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Pregnancy alters lipid metabolism, but the adaptation of PLTP to pregnancy remains poorly understood. This study investigated longitudinal changes in PLTP gene expression and concentration during healthy pregnancy and pregnancy with cardiometabolic complications, and their associations with maternal lipid metabolism and inflammatory status. Methods: We followed 84 healthy and 20 pregnant women who developed gestational diabetes mellitus and hypertensive disorders during pregnancy. PLTP gene expression, PLTP concentration, advanced lipid profile parameters, and inflammatory status were analysed throughout the trimesters. Results: Comparable trajectories of changes in PLTP gene expression and PLTP concentrations were observed in both groups, but PLTP gene expression in the first trimester was significantly lower in the group with complications (p&amp;lt;0.05). Analysis of serum non-cholesterol sterols in HDL subfractions (NCSHDL) and plasma ceramides [ceramide C16:0 (Cer C16:0), ceramide C24:0 (Cer C24:0)] has revealed significantly lower desmosterolHDL (p&amp;lt;0.05), while significantly higher C24:0 (p&amp;lt;0.001). Conclusion: Our results showed altered PLTP gene expression, advanced lipid profile, and inflammatory status in the first trimester of pregnancy with cardiometabolic complications. Our findings emphasize the importance of a thorough investigation of lipid metabolism and inflammatory pathways in early pregnancy to improve the outcomes.<\/jats:p>","DOI":"10.5937\/jomb0-64876","type":"journal-article","created":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T09:43:39Z","timestamp":1772185419000},"page":"841-855","source":"Crossref","is-referenced-by-count":0,"title":["Phospholipid transfer protein: The link between lipid metabolism and inflammation in healthy pregnancy and pregnancy with cardiometabolic complications"],"prefix":"10.5937","volume":"45","author":[{"given":"Marko","family":"Stankovi\u0107","sequence":"first","affiliation":[{"name":"Gynaecology and Obstetrics Clinic Narodni Front, Belgrade"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4576-1722","authenticated-orcid":false,"given":"Jelena","family":"Munja\u0161","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02qsmb048","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minja","family":"Derikonji\u0107","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02qsmb048","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6417-8404","authenticated-orcid":false,"given":"Aleksandra","family":"\u017deljkovi\u0107","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02qsmb048","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7445-0504","authenticated-orcid":false,"given":"Jelena","family":"Veki\u0107","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02qsmb048","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1833-7827","authenticated-orcid":false,"given":"Tamara","family":"Antoni\u0107","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02qsmb048","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Ardali\u0107","sequence":"additional","affiliation":[{"name":"Gynaecology and Obstetrics Clinic Narodni Front, Belgrade"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milica","family":"Miljkovi\u0107-Trailovi\u0107","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02qsmb048","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7591-8885","authenticated-orcid":false,"given":"Marija","family":"\u0160ari\u0107-Matutinovi\u0107","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02qsmb048","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1125-3076","authenticated-orcid":false,"given":"Tamara","family":"Gojkovi\u0107","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02qsmb048","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6878-8645","authenticated-orcid":false,"given":"Sne\u017eana","family":"Jovi\u010di\u0107","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02qsmb048","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4247-3290","authenticated-orcid":false,"given":"\u017deljko","family":"Mikovi\u0107","sequence":"additional","affiliation":[{"name":"Gynaecology and Obstetrics Clinic Narodni Front, Belgrade"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0331-6807","authenticated-orcid":false,"given":"Aleksandra","family":"Stefanovi\u0107","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02qsmb048","id-type":"ROR","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3964","reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Mulder JWCM, Kusters DM, Roeters van Lennep JE. 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Mol Biol Rep 2021; 48(12): 8171-8180. doi: 10.1007\/s11033-021-06785-0;","DOI":"10.1007\/s11033-021-06785-0"},{"key":"ref41","doi-asserted-by":"crossref","unstructured":"Kumasri R, Singh H. The Prevalence of Elevated High-Sensitivity C-Reactive Protein in Normal Pregnancy and Gestational Diabetes Mellitus. J Fam Med Prim Care 2017; 6: 259-64. doi: 10.4103\/2249-4863.219995;","DOI":"10.4103\/2249-4863.219995"}],"container-title":["Journal of Medical Biochemistry"],"original-title":["Fosfolipidni transfer protein - veza izme\u0111u metabolizma lipida i inflamacije u zdravoj trudno\u0107i i trudno\u0107i sa kardiometaboli\u010dkim komplikacijama"],"language":"en","link":[{"URL":"https:\/\/aseestant.ceon.rs\/index.php\/jomb\/article\/download\/64876\/30276","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/scindeks-clanci.ceon.rs\/data\/pdf\/1452-8258\/2026\/1452-82582604841S.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T14:17:21Z","timestamp":1776262641000},"score":1,"resource":{"primary":{"URL":"https:\/\/scindeks.ceon.rs\/Article.aspx?artid=1452-82582604841S"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.5937\/jomb0-64876","relation":{},"ISSN":["1452-8258","1452-8266"],"issn-type":[{"value":"1452-8258","type":"print"},{"value":"1452-8266","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}