{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T14:31:53Z","timestamp":1788273113087,"version":"build-2803163510"},"reference-count":40,"publisher":"The Korean Society of Gastrointestinal Endoscopy","issue":"5","license":[{"start":{"date-parts":[[2021,3,4]],"date-time":"2021-03-04T00:00:00Z","timestamp":1614816000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"name":"The Health and Medical Care Committee of the Regional Executive Board, Region V\u00e4stra G\u00f6taland","award":["VGFOUREG-564381"],"award-info":[{"award-number":["VGFOUREG-564381"]}]},{"DOI":"10.13039\/501100005754","name":"Sahlgrenska University Hospital","doi-asserted-by":"crossref","award":["ALFGBG-875671"],"award-info":[{"award-number":["ALFGBG-875671"]}],"id":[{"id":"10.13039\/501100005754","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Assar Gabrielsson Foundation","award":["17-20"],"award-info":[{"award-number":["17-20"]}]},{"name":"Magtarmfonden","award":["79211"],"award-info":[{"award-number":["79211"]}]}],"content-domain":{"domain":["e-ce.org"],"crossmark-restriction":true},"short-container-title":["Clin Endosc"],"published-print":{"date-parts":[[2021,9,30]]},"abstract":"<jats:p>Background\/Aims: The diagnostic work-up of lymphadenopathy is challenging but important to determine the correct therapy. Nevertheless, few studies have addressed the topic of endosonography (EUS)-guided tissue acquisition in lymphadenopathy. Therefore, we aimed to evaluate the accuracy and safety of EUS-guided fine-needle biopsy sampling (EUS-FNB) in intrathoracic and intraabdominal lymphadenopathy.Methods: In a tertiary care center, patients with lymphadenopathy referred for EUS-guided sampling were included prospectively from 2014 to 2019 (NCT02360839). In all cases, EUS-FNB (22 gauge) and EUS-guided fine-needle aspiration (EUS-FNA) (25 gauge) were performed. The patients were randomized to the first needle pass with FNB or FNA. Study outcomes were the diagnostic accuracy and adverse event rate.Results: Forty-eight patients were included (median age: 69 years [interquartile range, 59\u201376]; 24\/48 females [50%]). The final diagnoses were metastasis (n=17), lymphoma (n=11), sarcoidosis (n=6), and inflammatory disease (n=14). The diagnostic performance of the two modalities was comparable, including a high sensitivity for metastatic nodes (EUS-FNB: 87% vs. EUSFNA: 100%, p=0.5). The sensitivity for lymphoma was borderline superior in favor of EUS-FNB (EUS-FNB: 55% vs. EUS-FNA: 9%, p=0.06). No adverse events were recorded.Conclusions: In lymphadenopathy, both EUS-FNB and EUS-FNA are safe and highly sensitive for metastatic lymph node detection. Lymphoma diagnosis is challenging regardless of the needle used.<\/jats:p>","DOI":"10.5946\/ce.2020.283","type":"journal-article","created":{"date-parts":[[2021,3,4]],"date-time":"2021-03-04T08:05:53Z","timestamp":1614845153000},"page":"722-729","update-policy":"https:\/\/doi.org\/10.5946\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["High Sensitivity of Endoscopic Ultrasound-Guided Fine-Needle Aspiration and Endoscopic Ultrasound-Guided Fine-Needle Biopsy in Lymphadenopathy Caused by Metastatic Disease: A Prospective Comparative Study"],"prefix":"10.5946","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4106-1454","authenticated-orcid":true,"given":"Per","family":"Hedenstr\u00f6m","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3280-1289","authenticated-orcid":true,"given":"Vasilis","family":"Chatzikyriakos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4108-5728","authenticated-orcid":true,"given":"Roozbeh","family":"Shams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9862-5441","authenticated-orcid":true,"given":"Catarina","family":"Lewerin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2117-5825","authenticated-orcid":true,"given":"Riadh","family":"Sadik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3961","reference":[{"key":"ref1","first-page":"896","volume-title":"Unexplained lymphadenopathy: evaluation and differential diagnosis","author":"Gaddey","year":"2016"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.4065\/75.7.723"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2010.02.012"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-109021"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/s0016-5107(94)70206-3"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.4103\/0366-6999.167296"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0212427"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2011.12.032"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.3028"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/lbr.0000000000000552"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1177\/2050640615577533"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-017-5808-2"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1326268"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/dc.24103"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-03-657379"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s10353-018-0551-z"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.4103\/2303-9027.117767"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1393354"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1390889"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1002\/dc.22971"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1344217"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2018.10.026"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.5946\/ce.2019.170"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.2019.1704052"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2016.02.045"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.350"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw400"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdv304"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1111\/1751-2980.12381"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1377558"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1038\/s41395-018-0025-8"},{"key":"ref32","first-page":"351","volume-title":"Endoscopic ultrasound-guided fine-needle aspiration. 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