{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:31:01Z","timestamp":1790778661619,"version":"4.1.0"},"reference-count":30,"publisher":"The Korean Society of Gastrointestinal Endoscopy","issue":"6","license":[{"start":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["e-ce.org"],"crossmark-restriction":true},"short-container-title":["Clin Endosc"],"published-print":{"date-parts":[[2024,11,30]]},"abstract":"<jats:p>Background\/Aims: Polyethylene glycol (PEG) is considered the gold standard regimen for bowel preparation; however, due to the necessity of a large volume, patient tolerance is impaired. Therefore, lactulose is a novel alternative for colonoscopy preparation. This study aimed to investigate the efficacy and safety of lactulose-based bowel preparations in comparison with PEG for colonoscopy.Methods: This is a prospective, non-blinded, comparative study. Outpatients were randomly divided into two groups: group 1 (111 patients), PEG; and group 2 (111 patients), lactulose. The following clinical outcomes were assessed in each group: degree of bowel clearance using the Boston bowel preparation score, colorectal polyp detection rate, adenoma detection rate, tolerability, and side effects.Results: The rate of inadequate bowel preparation was 8.1% and 1.8% for the PEG and lactulose groups, respectively (p=0.030). The Boston bowel preparation score for the entire colon was 7.34\u00b11.17 and 8.36\u00b11.09 for the PEG and lactulose groups, respectively (p&lt;0.001). The satisfactory overall experience rates were 27.9% and 62.2% for the PEG and lactulose groups, respectively (p&lt;0.001).Conclusions: The novel bowel preparation with oral lactulose was superior to that with PEG in terms of colon cleansing, adenoma detection rate, tolerance, and patient experience.<\/jats:p>","DOI":"10.5946\/ce.2024.056","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T06:24:37Z","timestamp":1729578277000},"page":"775-782","update-policy":"https:\/\/doi.org\/10.5946\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Novel regimen for colonoscopy bowel preparation with oral lactulose: a prospective comparative study"],"prefix":"10.5946","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2673-3360","authenticated-orcid":true,"given":"Josu\u00e9 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