{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:56:11Z","timestamp":1790733371676,"version":"4.1.0"},"reference-count":32,"publisher":"The Korean Society of Gastrointestinal Endoscopy","issue":"5","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["e-ce.org"],"crossmark-restriction":true},"short-container-title":["Clin Endosc"],"published-print":{"date-parts":[[2026,9,30]]},"abstract":"<jats:p>Background\/Aims: Although endoscopic glue injection is the conventional first-line treatment for gastric variceal (GV) bleeding, a large body of evidence supports the safety and effectiveness of endoscopic ultrasound (EUS)-guided coil and glue injections. We compared the safety and efficacy of these two modalities.Methods: A random-effects model was used for the pooled estimates. The outcomes of interest were the odds of technical success, GV obliteration, adverse events, rebleeding, reintervention, and pulmonary embolization (PE).Results: Eight studies involving 659 patients (EUS-guided coil+glue, n=200; endoscopic glue, n=459) were included in the meta-analysis. The rebleeding (odds ratio [OR], 0.28, 95% confidence interval [CI], 0.16\u20130.51; I2=0%) and reintervention (OR, 0.28; 95% CI, 0.15\u20130.52; I2=0%) rates were significantly lower in the EUS-guided coil+glue. EUS-guided coil+glue group had higher rates (OR, 4.56; 95% CI, 2.04 \u201310.19; I2=30%) of GV obliteration after the first session. No difference in the odds of technical success (OR, 2.03; 95% CI, 0.50\u20138.22; I2=0%), adverse events (OR, 1.19; 95% CI, 0.44\u20133.20; I2=45%), abdominal pain (OR, 1.17; 95% CI, 0.36\u20133.82; I2=44%) fever (OR, 1.09; 95% CI, 0.41\u20132.92; I2=0%), PE (OR, 0.52; 95% CI, 0.19\u20131.47; I2=0%) and all-cause mortality (OR, 0.67; 95% CI, 0.32\u20131.40; I2=0%) was identified.Conclusions: EUS-guided coil and glue injections are safe and effective for the treatment of gastric varices.<\/jats:p>","DOI":"10.5946\/ce.2025.251","type":"journal-article","created":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T23:24:15Z","timestamp":1790551455000},"page":"741-753","update-policy":"https:\/\/doi.org\/10.5946\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Safety and effectiveness of endoscopic ultrasound-guided coil plus glue vs. direct endoscopic glue injection for the treatment of gastric varices: a systematic review and meta-analysis"],"prefix":"10.5946","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7562-7420","authenticated-orcid":true,"given":"Zahid Ijaz","family":"Tarar","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, University of Missouri School of Medicine, Columbia, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6338-0712","authenticated-orcid":true,"given":"Mustafa","family":"Gandhi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, KPC Medical College and Hospital, Kolkata, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8272-0172","authenticated-orcid":true,"given":"Umer","family":"Farooq","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Saint Louis University, St. Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8079-6011","authenticated-orcid":true,"given":"Gopala K.","family":"Konduri","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Missouri School of Medicine, Columbia, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9424-6383","authenticated-orcid":true,"given":"Ahmad","family":"Zain","sequence":"additional","affiliation":[{"name":"Department of Medicine, UCHealth Parkview Medical Center, Pueblo, CO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8766-4587","authenticated-orcid":true,"given":"Zohaib","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, University of Toledo, Toledo, OH, 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